Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2017, 161(3):242-251 | DOI: 10.5507/bp.2017.025

Compartment syndrome and regional anaesthesia: Critical review

Jozef Kluckaa, Petr Stouraca, Alena Stouracovab, Michal Masekc, Martin Repkod
a Department of Paediatric Anaesthesiology and Intensive Care Medicine, Faculty of Medicine, Masaryk University and University Hospital Brno, Jihlavska 20, 625 00 Brno, Czech Republic
b Department of Radiology, Faculty of Medicine, Masaryk University and University Hospital Brno, Jihlavska 20, 625 00 Brno, Czech Republic
c Department of Traumatic Surgery, Faculty of Medicine, Masaryk University and University Hospital Brno, Jihlavska 20, 625 00 Brno, Czech Republic
d Department of Orthopaedic Surgery, Faculty of Medicine, Masaryk University and University Hospital Brno, Jihlavska 20, 625 00 Brno, Czech Republic

Acute compartment syndrome (ACS) is a potential orthopaedic/traumatology emergency. Without prompt, precise diagnosis and immediate treatment with surgical decompressive fasciotomy it can lead to neurological dysfunction and disability. The role of regional anaesthesia (RA) in patients at risk for ACS/ and in those with developed ACS is controversial. The aim of this critical review was to answer the question, whether regional anaesthesia can delay the diagnosis. The authors use an evidence-based approach to discuss these high risk patients in considering RA as a method of choice for effective analgesia. To the date of data collection, there was no single case report identified where RA alone led to delay in ACS diagnosis and surgical treatment. In four clinical cases, epidural analgesia can be associated with delayed ACS diagnosis. Frequent clinical evaluation and breakthrough pain despite a functional RA in combination with intracompartment pressure measurement remains the keystone of recommended management for patients at risk of ACS.

Keywords: compartment syndrome, regional anaesthesia, peripheral nerve block, blockade

Received: December 16, 2016; Accepted: May 5, 2017; Prepublished online: May 24, 2017; Published: September 26, 2017  Show citation

ACS AIP APA ASA Harvard Chicago IEEE ISO690 MLA NLM Turabian Vancouver
Klucka, J., Stourac, P., Stouracova, A., Masek, M., & Repko, M. (2017). Compartment syndrome and regional anaesthesia: Critical review. Biomedical papers161(3), 242-251. doi: 10.5507/bp.2017.025
Download citation

References

  1. Tzioupis C, Cox G, Giannoudis PV. Acute compartment syndrome of the lower extremity: an update. Orthopaed Trauma 2009;23(6):433-40. Go to original source...
  2. Janzing H. Epidemiology, etiology, pathophysiology and diagnosis of the acute compartment syndrome of the extremity. Eur J Trauma Emerg Surg 2007;33(6):576-83. Go to original source... Go to PubMed...
  3. Walker BJ, Noonan KJ, Bosenberg AT. Evolving compartment syndrome not masked by a continuous peripheral nerve block:evidence-based case management. Reg Anesth Pain Med 2012;37(4):393-7. Go to original source... Go to PubMed...
  4. Sermeus L, Boeckx S, Camerlynck H, Somville J, Vercauteren M. Postsurgical compartment syndrome of the forearm diagnosed in a child receiving a continuous infra-clavicular peripheral nerve block. Acta Anaesthiol Belg 2015;66(1):29-32.
  5. Mannion S, Capdevila X. Acute compartment syndrome and the role of regional anesthesia. Int. Anesthesiol Clin 2010;48(4):85-105. Go to original source... Go to PubMed...
  6. Elliott KG, Johnstone AJ. Diagnosing acute compartment syndrome. J Bone Joint Surg Br 2003;85(5):625-32. Go to original source... Go to PubMed...
  7. Harris C, Hobson M. The management of soft tissue injuries and compartment syndrome. Surgery 2015;33(6):251-6. Go to original source...
  8. McQueen MM, Gaston P, Court-Brown CM. Acute compartment syndrome. Who is at risk? J Bone Joint Surg Br 2000;82(2):200-3. Go to original source... Go to PubMed...
  9. Mossetti V, Ivani G. Controversial issues in pediatric regional anesthesia. Pediatr Anaesth 2012;22(1)109-14. Go to original source...
  10. Blick SS, Brumback RJ, Poka A, Burgess AR, Ebraheim NA. Compartment syndrome in open tibial fractures. J. Bone Joint Surg 1986;68(9):1348-53. Go to original source... Go to PubMed...
  11. Ferlic PW, Singer G, Kraus T, Eberl R. The acute compartment syndrome following fractures of the lower leg in children. Injury 2012;43(10):1743-6. Go to original source... Go to PubMed...
  12. Park S, Ahn J, Gee AO, Kuntz AF, Esterhai JL.Compartment syndrome in tibial fractures. J. Orthopaed. Trauma 2009;23(7):514-8. Go to original source...
  13. Tiwari A, Haq AI, Myint F, Hamilton G. Acute compartment syndromes. Br. J. Surg 2002;89(4):397-412. Go to original source... Go to PubMed...
  14. Wall CJ, Lynch J, Harris IA, Richardson MD, Brand C, Lowe AJ, Suqrue M. Clinical practice guidelines for the management of acute limb compartment syndrome following trauma. ANZ J. Surg 2010;80(3):151-6. Go to original source... Go to PubMed...
  15. Ojike NI, Roberts CS, Giannoudis P. Compartment syndrome of the thigh: a systematic review. Injury 2010;41(2):133-6. Go to original source... Go to PubMed...
  16. Ozkayin N, Aktuglu K. Absolute compartment pressure versus differential pressure for the diagnosis of compartment syndrome in tibial fractures. Int. Orthop 2005;29(6):396-401. Go to original source... Go to PubMed...
  17. Wright EM. Neurovascular impairment and compartment syndrome: a literature review. Paediatr Nurs 2009;21(3):26-9. Go to original source...
  18. Kalyani BS, Fisher BE, Roberts CS, Giannoudis PV. Compartment syndrome of the forearm: a systematic review. J. Hand Surg 2011;36(3):535-43. Go to original source...
  19. Ali P, Santy-Tomlinson J, Watson R. Assessment and diagnosis of acute limb compartment syndrome:A literature review. International Journal of Orthopaedic and Trauma Nursing 2014;18(4):180-90. Go to original source...
  20. Panchamia JK, Orebaugh S. Acute Compartment Syndrome and Regional Anesthesiology - What Residents on the Acute Pain Management Service Should Know. American Society of Regional Anesthesia and Pain Medicine [serial on the Internet]. 2013 November. Available from: https://www.asra.com/content/documents/nov-13_asra_news.pdf
  21. Olson SA, Glasgow RR. Acute compartment syndrome in lower extremity musculoskeletal trauma. J Am Acad Orthop Surg 2005;13(7):436-44. Go to original source... Go to PubMed...
  22. Tiwari A, Haq AI, Myint F, Hamilton G. Acute compartment syndromes. Br J Surg 2002; 89(4):397-412. Go to original source... Go to PubMed...
  23. Mar GJ, Barrington MJ, McGuirk BR. Acute compartment syndrome of the lower limb and the effect of postoperative analgesia on diagnosis. British Journal of Anaesthesia 2009;102(1):3-11. Go to original source... Go to PubMed...
  24. Kosir R, Moore FA, Selby JH, Cocanour CS, Kozar RA, Gonzalez EA, Todd SR: Acute lower extremity compartment syndrome (ALECS) screening protocol in critically ill trauma patients. J Trauma 2007;63(2):268-75. Go to original source... Go to PubMed...
  25. Ulmer T. The clinical diagnosis of compartment syndrome of the lower leg: are clinical findings predictive of the disorder? J Orthop Trauma 2002;16(8):572-7. Go to original source... Go to PubMed...
  26. O'Sullivan MJ, Rice J, McGuinness AJ. Compartment syndrome without pain! Ir Med J 2002;95(1):22. Go to PubMed...
  27. McQueen MM, Christie J, Court-Brown CM. Acute compartment syndrome in tibial diaphyseal fractures. J Bone Joint Surg Br 1996;78(1):95-8. Go to original source...
  28. Shadgan B, Menon M, O'Brien PJ, Reid WD. Diagnostic techniques in acute compartment syndrome of the leg. J. Orthop Trauma 2008;22(8):581-7. Go to original source... Go to PubMed...
  29. Tuckey J. Bilateral compartment syndrome complicating prolonged lithotomy position. Br J Anaesth 1996;77(4):546-9. Go to original source... Go to PubMed...
  30. Staudt JM, Smeulders MJ, van der Horst CM. Normal compartment pressures of the lower leg in children. J Bone Joint Surg Br 2008;90(2):215-9. Go to original source... Go to PubMed...
  31. Mubarak SJ, Owen CA, Hargens AR, Garetto LP, Akeson WH. Acute compartment syndromes: diagnosis and treatment with the aid of the wick catheter. J Bone Joint Surg Am 1978;60(8):1091-5. Go to original source... Go to PubMed...
  32. Matsen FA 3rd, Veith RG. Compartmental syndromes in children. J Pediatr Orthop 1981;1(1):33-41. Go to original source... Go to PubMed...
  33. McHale PM, LoVecchio F. Narcotic analgesia in the acute abdomen - a review of prospective trials. Eur J Emerg Med 2001;8(2):131-6. Go to original source... Go to PubMed...
  34. Mubarak SJ, Pedowitz RA, Hargens AR. Compartment syndromes. Curr Orthop 1989; (3):36-40. Go to original source...
  35. Whitesides TE, Haney TC, Morimoto K, Harada H. Tissue pressure measurements as a determinant for the need of fasciotomy. Clin Orthop Relat Res 1975;(113):43-51. Go to original source...
  36. White TO, Howell GE, Will EM, Court-Brown CM, McQueen MM. Elevated intramuscular compartment pressures do not infl uence outcome after tibial fracture. J Trauma 2003;55(6):1133-8. Go to original source... Go to PubMed...
  37. Garner AJ, Handa A. Screening tools in the diagnosis of acute compartment syndrome. Angiology 2010;61(5):475-81. Go to original source... Go to PubMed...
  38. Aguirre JA, Gresch D, Popovici A, Bernhard J, Borgeat A. Case Scenario: Compartment Syndrome of the Forearm in Patient with an Infraclavicular Catheter. Anesthesiology 2013; 118(5):1198-205. Go to original source... Go to PubMed...
  39. Hayakawa H, Aldington DJ, Moore RA: Acute traumatic compartment syndrome: A systematic review of results of fasciotomy. Trauma 2009;11(1):5-35. Go to original source...
  40. Cascio BM, Pateder DB, Wilckens JH, Frassica FJ: Compartment syndrome: Time from diagnosis to fasciotomy. J Surg Orthop Adv 2005;14(3):117-21; discussion 120-1. Go to PubMed...
  41. Dunwoody JM, Reichert CC, Brown KL. Compartment Syndrome Associated with Bupivacaine and Fentanyl Epidural Analgesia in Paediatric Orthopaedics. J Paediatr Orthop 1997;17(3):285-8. Go to original source...
  42. Mubarak SJ, Wilton NC. Compartment syndromes and epidural analgesia. J Paediatr Orthop 1997;17(3):282-4. Go to original source...
  43. Whitesides TE. Pain:friend or foe. J Bone Joint Surg Am 2001; 83-A(9):1424-5. Go to original source... Go to PubMed...
  44. Tang WM, Chiu KY. Silent compartment syndrome complicating total knee arthroplasty: continuous epidural anesthesia masked the pain. J Arthroplasty 2000;15(2):241-3. Go to original source... Go to PubMed...
  45. Somayaji HS, Hassan AN, Reddy K, Heatley FW. Bilateral gluteal compartment syndrome after total hip arthroplasty under epidural anesthesia. J Arthroplasty 2005 ;20(8):1081-3. Go to original source... Go to PubMed...
  46. Kumar V, Saeed K, Panagopoulos A, Parker PJ. Gluteal compartment syndrome following joint arthroplasty under epidural anaesthesia: a report of 4 cases. J Orthop Surg (Hong Kong) 2007;15(1):113-7. Go to original source... Go to PubMed...
  47. Maletis GB, Watson RC, Scott S. Compartment syndrome. A complication of intravenous regional anesthesia in the reduction of lower leg shaft fractures. Orthopedics 1989;12(6):841-6. Go to original source... Go to PubMed...
  48. Driscoll EB, Maleki AH, Jahromi L, Hermecz BN, Nelson LE, Vetter IL, Evenhuis S, Riesenberg LA. Regional anesthesia or patient-controlled analgesia and compartment syndrome in orthopedic surgical procedures: a systematic review. Local Reg Anesth 2016;6(9):65-81. Go to original source...
  49. Richman JM, Liu SS, Courpas G, et al. Does continuous peripheral nerve block provide superior pain control to opioids? A meta-analysis. Anesth Analg 2006;102(1):248-57. Go to original source... Go to PubMed...
  50. Harrington P, Bunola J, Jennings AJ, Bush DJ, Smith RM. Acute compartment syndrome masked by intravenous morphine from a patient-controlled analgesia pump. Injury 2000;31(5):387-9. Go to original source... Go to PubMed...
  51. O'Sullivan ST, O'Donoghue J, McGuinness AJ, O'Shaughnessy M. Does patient-controlled analgesia lead to delayed diagnosis of lower limb compartment syndrome? Plast Reconstr Surg 1996;97(5):1087-8. Go to original source... Go to PubMed...
  52. Richards H, Langston A, Kulkarni R, Downes EM, Does patient controlled analgesia delay the diagnosis of compartment syndrome following intramedullary nailing of the tibia? Injury 2004;35(3):296-8. Go to original source... Go to PubMed...
  53. Cometa MA, Esch AT, Boezaart AP. Did continuous femoral and sciatic nerve block obscure the diagnosis or delay the treatment of acute lower leg compartment syndrome? A case report. Pain Med 2011;12(5):823-8. Go to original source... Go to PubMed...
  54. Walker BJ, Noonan KJ, Bosenberg AT. Evolving compartment syndrome not masked by a continuous peripheral nerve block: Evidence-based case management. Reg Anesth Pain Med 2012;37(4):393-7. Go to original source... Go to PubMed...
  55. Wu JJ, Lollo L, Grabinsky A. Regional anesthesia in trauma medicine. Anesthesiol Res Pract 2011; 2011: 713281. Published online 2011 Nov 21. doi:  10.1155/2011/713281 Go to original source... Go to PubMed...
  56. Soni S, Johannsson H. Does regional anaesthesia in trauma patients lead to delayed recognition of compartment syndrome? Br J Hosp Med (Lond) 2013;74(6):358. Go to original source... Go to PubMed...
  57. Kucera TJ, Boezaart AP. Case Report Regional Anesthesia Does Not Consistently Block Ischemic Pain: Two Further Cases and a Review of the Literature. Pain Medicine 2014;15(2):316-9. Go to original source... Go to PubMed...
  58. Uzel AP, Steinmann G. Thigh compartment syndrome after intramedullary femoral nailing: possible femoral nerve block influence on diagnosis timing. Orthop Traumatol Surg Res 2009;95(4):309-13. Go to original source... Go to PubMed...
  59. Rauf J, Iohom G, O'Donnell B. Acute compartment syndrome and regional anaesthesia - a case report. Rom J Anaesth Int Care 2015;22(1):51-54.
  60. Munk-Andersen H, Laustrup TK. Compartment syndrome diagnosed in due time by breakthrough pain despite continuous peripheral nerve block. Acta Anaesthesiol Scand 2013;57(10):1328-30. Go to original source... Go to PubMed...
  61. Ganeshan RM, Mamoowala N, Ward M, Sochart D. Acute compartment syndrome risk in fracture fixation with regional blocks. BMJ Case Rep 2015 Nov 26;2015. pii: bcr2015210499. doi: 10.1136/bcr-2015-210499. Go to original source...
  62. Ananthanarayan C, Castro C, McKee N, Sakotic G. Compartment syndrome following intravenous regional anesthesia. Can J Anaesth 2000;47(11):1094-8. Go to original source... Go to PubMed...
  63. Strecker WB, Wood MB, Bieber EJ. Compartment syndrome masked by epidural anesthesia for postoperative pain. Report of a case. .J Bone Joint Surg Am 1986; 68(9):1447-8. Go to original source... Go to PubMed...
  64. Pinheiro AA, Marques PM, Sá PM, Oliveira CF, da Silva BP, de Sousa CM. Compartment syndrome after total knee arthroplasty: regarding a clinical case. Rev Bras Ortop. 2015;50(4):478-81. Go to original source... Go to PubMed...
  65. Ross O. Central neural blockade and compartment syndrome. Anaesthesia 1999;54:297. Go to original source... Go to PubMed...