- P-ISSN 2233-4203
- E-ISSN 2093-8950
- Apply for Authority
- P-ISSN2233-4203
- E-ISSN2093-8950
Article Detail
Home > Article Detail
Tertiary Matrices for the Analysis of Polyethylene Glycols Using MALDI-TOF MS
Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2014, v.5 no.2, pp.49-51
https://doi.org/10.5478/MSL.2014.5.2.49
(Chungnam National University)
(Chungnam National University)
(Chungnam National University)
(Chungnam National University)
(Chungnam National University)
Hong,
J., Kim,
T., &
Kim,
J.
(2014). Tertiary Matrices for the Analysis of Polyethylene Glycols Using MALDI-TOF MS. Mass Spectrometry Letters, 5(2), 49-51, https://doi.org/10.5478/MSL.2014.5.2.49
- Downloaded
- Viewed
Abstract
The effectiveness of tertiary matrices composed of the combination of three common matrices (dihydrobenzoic acid(DHB), α-cyano-4-hydroxycinnamic acid (CHCA), and sinapinic acid (SA)) was compared with that of single or binary matricesin the analysis of polyethylene glycol (PEG) polymers ranging from 1400 to 10000 Da using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). A tertiary matrix of 2,5-DHB+CHCA+SA was the mosteffective in terms of S/N ratios. CHCA and CHCA+SA produced the highest S/N ratios among the single matrices and thebinary matrices, respectively. The improvement observed when using a tertiary matrix in analyses of PEG polymers by MALDITOFMS is believed to be due to the uniform morphology of the MALDI sample spots and synergistic effects arising from themixture of the three matrix materials.
- keywords
- MALDI-TOF MS, tertiary matrix, polyethylene glycols, 2, 5-dihydrobenzoic acid, α-cyano-4-hydroxycinnamic acid, sinapinic acid
Reference
1
Shanta, S. R.. (2011). . Anal. Chem, 83, 1252-.
2
Yang, C.. (2010). . J. Am. Soc. Mass Spectrom, 21, 294-.
3
Knop, K.. (2010). . Angew. Chem. Int. Ed, 49, 6288-.
4
Junejo, Y.. (2013). . Cent. Eur. J. Chem, 11, 1527-.
5
Scott, R. A.. (1999). . Biomaterials, 20, 1371-.
6
de Koster, C. G.. (1995). . Rapid Commun. Mass Spectrom, 9, 957-.
7
Hanton, S. D.. (1999). . J. Am. Soc. Mass Spectrom, 10, 104-.
8
Aera Lee. (2009). Effect of Dihydroxybenzoic Acid Isomers on the Analysis of Polyethylene Glycols in MALDI-MS. Bulletin of the Korean Chemical Society, 30(5), 1127-1130.
9
Erra-Balsells, R.. (2003). . Arkivoc, 2003, 517-.
10
Enjalbal, C.. (2005). . J. Am. Soc. Mass Spectrom, 16, 670-.
11
Padliya, N. D.. (2008). . Anal. Chim. Acta, 627, 162-.
- Submission Date
- 2014-05-11
- Revised Date
- 2014-06-02
- Accepted Date
- 2014-06-05
Other articles from this issue
- Diagnostic Evaluation of Enzyme Activity Related to Steroid Metabolism by Mass Spectrometry-Based Steroid Profiling
- Simultaneous Determination of Five Porphyrins in Human Urine and Plasma Using High Performance Liquid Chromatography-Tandem Mass Spectrometry
- Tertiary Matrices for the Analysis of Polyethylene Glycols Using MALDI-TOF MS
- Optimization of Enzyme Digestion Conditions for Quantification of Glycated Hemoglobin Using Isotope Dilution Liquid Chromatography-Tandem Mass Spectrometry
- Accurate Measurement of Arsenic in Laver by Gravimetric Standard Addition Method Combined with High Resolution Inductively Coupled Plasma Mass Spectrometry
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.