1887
Volume 2023, Issue 4
  • ISSN: 0253-8253
  • EISSN: 2227-0426

Abstract

Background: Febrile seizures, convulsive episodes in young children during febrile illnesses, are a significant concern due to their potential for recurrence and associated uncertainties. This study investigated the causes and risks associated with recurrent febrile seizures and the critical role of electroencephalogram (EEG) in their accurate diagnosis.

Methods: Following Institutional Review Board approval and going through the consenting process with parents, this study gathered the clinical features and EEG recordings of children admitted with febrile seizures in the Department of Pediatrics, Mahatma Gandhi Memorial Hospital, Kakatiya Medical College, Warangal, Telangana, India. Descriptive statistics, including mean, standard deviation (SD), frequencies, and percentages, were computed to understand the data comprehensively. The Chi-Square test was employed to analyze the association between variables, with a significance level of 0.05, ensuring reliable and trustworthy findings.

Results: Out of 42 children studied, 28 (66.67%) presented with simple febrile seizures, with the mean time of occurrence of seizures from the onset of fever being 7.85 hours. Abnormal EEG was seen in 50% of children with complex febrile seizures and 16% with simple febrile seizures. Generalized epileptiform discharges were the most common epileptic activity observed. Low sodium levels had a significant relationship with febrile seizures in the analysis.

Conclusions: This study emphasizes the importance of EEG in diagnosing febrile seizures, particularly in complex cases. Our findings suggest that low sodium levels may be a significant risk factor for febrile seizures. Further research is necessary to identify other preventable risk factors to reduce the burden of the medical condition.

Loading

Article metrics loading...

/content/journals/10.5339/qmj.2023.32
2023-12-26
2024-05-22
Loading full text...

Full text loading...

/deliver/fulltext/qmj/2023/4/qmj.2023.32.html?itemId=/content/journals/10.5339/qmj.2023.32&mimeType=html&fmt=ahah

References

  1. Kliegman RM, Behrman RE, Jenson HB, Stanton BF. Nelson textbook of Pediatrics. 20th ed. Philadelphia, Pennsylvania: Elsevier; 2016. 2829 p.
    [Google Scholar]
  2. StatPearls [Internet] . Febrile Seizure; c2022. [Updated 2022 Jul 30; cited 2023 Jan 30]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK448123/
    [Google Scholar]
  3. Leung AK, Hon KL, Leung TN. Febrile seizures: an overview. Drugs Context. 2018 Jul 16; 7::212536. doi: 10.7573/dic.212536 .
    [Google Scholar]
  4. Batra P, Thakur N, Mahajan P, Patel R, Rai N, Trivedi N, et al.. An evidence-based approach to evaluation and management of the febrile child in Indian emergency department. Int J Crit Illn Inj Sci. 2018 Apr-Jun; 8:(2):63-72. doi: 10.4103/IJCIIS.IJCIIS_3_18 .
    [Google Scholar]
  5. Pavone P, Corsello G, Ruggieri M, Marino S, Marino S, Falsaperla R. Benign and severe early-life seizures: a round in the first year of life. Ital J Pediatr. 2018 May 15; 44:(1):54. doi: 10.1186/s13052-018-0491-z .
    [Google Scholar]
  6. Auvin S, Antonios M, Benoist G, Dommergues MA, Corrard F, Gajdos V, et al.. Évaluation d’un enfant après une crise fébrile : focus sur trois problèmes de pratique clinique [Evaluating a child after a febrile seizure: Insights on three important issues]. Arch Pediatr. 2017 Nov; 24:(11):1137-1146. French. doi: 10.1016/j.arcped.2017.08.018 .
    [Google Scholar]
  7. Kwon A, Kwak BO, Kim K, Ha J, Kim SJ, Bae SH, et al.. Cytokine levels in febrile seizure patients: A systematic review and meta-analysis. Seizure. 2018 Jul; 59::5-10. doi: 10.1016/j.seizure.201804.023 .
    [Google Scholar]
  8. Gowda VK, Kulhalli P Jr, Benakappa N Sr, Benakappa A. Etiological Profile of Afebrile Seizures in Infants in a Tertiary Care Center from southern India. J Pediatr Neurosci. 2019 Apr-Jun; 14:(2):82-85. doi: 10.4103/jpn.JPN_61_18 .
    [Google Scholar]
  9. Charan J, Biswas T. How to calculate sample size for different study designs in medical research? Indian J Psychol Med. 2013 Apr; 35:(2):121-6. doi: 10.4103/0253-7176.116232 .
    [Google Scholar]
  10. Sharma SK, Mudgal SK, Thakur K, Gaur R. How do you calculate sample size for observational and experimental nursing research studies? Natl J Physiol Pharm Pharmacol. 2020; 10:(1):1-8. doi: 10.5455/njppp.2020.10.0930717102019 .
    [Google Scholar]
  11. Fetveit A. Assessment of febrile seizures in children. Eur J Pediatr. 2008 Jan; 167:(1):17-27. doi: 10.1007/s00431-007-0577-x .
    [Google Scholar]
  12. Smith DK, Sadler KP, Benedum M. Febrile Seizures: Risks, Evaluation, and Prognosis. Am Fam Physician. 2019 Apr 1; 99:(7):445-450.
    [Google Scholar]
  13. Audenaert D, Van Broeckhoven C, De Jonghe P. Genes and loci involved in febrile seizures and related epilepsy syndromes. Hum Mutat. 2006 May; 27:(5):391-401. doi: 10.1002/humu.20279 .
    [Google Scholar]
  14. Hirtz DG, Nelson KB. The natural history of febrile seizures. Annu Rev Med. 1983; 34::453-71. doi: 10.1146/annurev.me.34.020183.002321 .
    [Google Scholar]
  15. Mewasingh LD. Febrile seizures. BMJ Clin Evid. 2014 Jan 31; 2014::0324.
    [Google Scholar]
  16. Angyo IA, Lawson JO, Okpeh ES. Febrile convulsions in Jos. Nig J Paediatr. 1997; 24::7–13.
    [Google Scholar]
  17. Swaiman KF, Ashwal S, Ferriero DM, Schor N. Swaiman’s Pediatric Neurology. 5th ed. Edinburgh: Elseiver Saunders; 2012. 790-96 p.
    [Google Scholar]
  18. Maytal J, Steele R, Eviatar L, Novak G. The value of early postictal EEG in children with complex febrile seizures. Epilepsia. 2000 Feb; 41:(2):219-21. doi: 10.1111/j.1528-1157.2000.tb00143.x .
    [Google Scholar]
  19. Koepp MJ. Hippocampal sclerosis: cause or consequence of febrile seizures. J Neurol Neurosurg Psychiatry. 2000 Dec; 69:(6):716-7. doi: 10.1136/jnnp.69.6.716 .
    [Google Scholar]
  20. Harish J, Sundrai S. Clinical profile of hospitalized children with febrile seizures. Int. J. Sci. Res. 2020 Oct; 9:(10):37-38. doi: 10.36106/ijsr/5825710 .
    [Google Scholar]
  21. Jeong KA, Han MH, Lee EH, Chung S. Early postictal electroencephalography and correlation with clinical findings in children with febrile seizures. Korean J Pediatr. 2013 Dec; 56:(12):534-9. doi: 10.3345/kjp.2013.56.12.534 .
    [Google Scholar]
  22. Gallentine WB, Shinnar S, Hesdorffer DC, Epstein L, Nordli DR Jr, Lewis DV, et al.. Plasma cytokines associated with febrile status epilepticus in children: A potential biomarker for acute hippocampal injury. Epilepsia. 2017 Jun; 58:(6):1102-1111. doi: 10.1111/epi.13750 .
    [Google Scholar]
  23. Laino D, Mencaroni E, Esposito S. Management of Pediatric Febrile Seizures. Int J Environ Res Public Health. 2018 Oct 12; 15:(10):2232. doi: 10.3390/ijerph15102232 .
    [Google Scholar]
  24. Sheppard E, Lalancette E, Thébault-Dagher F, Lafontaine MP, Knoth IS, Gravel J, et al.. Cognitive and behavioural development in children presenting with complex febrile seizures: at onset and school age. Epileptic Disord. 2021 Apr 1; 23:(2):325-336. doi: 10.1684/epd.2021.1260 .
    [Google Scholar]
  25. Visser AM, Jaddoe VW, Ghassabian A, Schenk JJ, Verhulst FC, Hofman A, et al.. Febrile seizures and behavioural and cognitive outcomes in preschool children: the Generation R study. Dev Med Child Neurol. 2012 Nov; 54:(11):1006-11. doi: 10.1111/j.1469-8749.2012.04405.x .
    [Google Scholar]
  26. Berg AT, Shinnar S, Hauser WA, Alemany M, Shapiro ED, Salomon ME, et al.. A prospective study of recurrent febrile seizures. N Engl J Med. 1992 Oct 15; 327:(16):1122-7. doi: 10.1056/NEJM199210153271603 .
    [Google Scholar]
  27. Verity CM, Greenwood R, Golding J. Long-term intellectual and behavioral outcomes of children with febrile convulsions. N Engl J Med. 1998 Jun 11; 338:(24):1723-8. doi: 10.1056/NEJM199806113382403 .
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.5339/qmj.2023.32
Loading
/content/journals/10.5339/qmj.2023.32
Loading

Data & Media loading...

  • Article Type: Research Article
Keyword(s): childrenEEGFebrile seizuresrecurrencerisk factors and sodium levels
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error