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Published December 8, 2018 | Version v1
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The biological activity assessment of potential drugs acting on cardiovascular system using Lipinski and Veber Rules

Description

Kowalska Magdalena, Fijałkowski Łukasz, Nowaczyk Alicja. The biological activity assessment of potential drugs acting on cardiovascular system using Lipinski and Veber Rules. Journal of Education, Health and Sport. 2018;8(12):184-191. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.2066519

http://ojs.ukw.edu.pl/index.php/johs/article/view/6360

https://pbn.nauka.gov.pl/sedno-webapp/works/890560

 

 

 

 

 

The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26/01/2017).

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

 

© The Authors 2018;

This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland

Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.

(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.

 

The authors declare that there is no conflict of interests regarding the publication of this paper.

 

Received: 25.11.2018. Revised: 30.11.2018. Accepted: 08.12.2018.

 

 

 

 

 

The biological activity assessment of potential drugs acting on cardiovascular system using Lipinski and Veber Rules

 

Magdalena Kowalska, Łukasz Fijałkowski, Alicja Nowaczyk

 

Department of Organic Chemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Dr. A. Jurasza 2, 85-094 Bydgoszcz

 

 

Abstract

Advanced computational methods (in silico) play major role in the early stages of developing new pharmaceuticals. Precise knowledge on molecular structure gives the possibility of forecasting the drug candidates basic properties. Despite many drugs registered in the arrhythmia treatment, this disease currently is still a big therapeutic problem. Therefore, intensive search for new drugs acting on the cardiovascular system are performed.

In the presented work, 77 pyrrolidin-2-one derivatives were analyzed for antiarrhythmic activity. Values of the key parameters proposed by Lipinski and Veber were obtained using computational chemistry methods. It's worth pointing out that the studied group of derivatives shows similar physicochemical properties to the anti-arrhythmic drugs used.

 

Key words: Lipinski's rule, Veber rule, pyrrolidin-2-one derivatives

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