Optimizing Growth Hormone Therapy in Chilhood Growth Hormone Defiency

Darendeliler Fatma

doi:https://dx.doi.org/10.5222/j.child.2014.148

Review

DOI :10.5222/j.child.2014.148 IUP :10.5222/j.child.2014.148 Full Text (PDF)

Optimizing Growth Hormone Therapy in Chilhood Growth Hormone Defiency

The diagnosis and treatment of growth hormone deficiency (GHD) are challenging issues with no clear-cut consensus on the diagnostic criteria and which children should be treated. Optimal treatment of growth disorders depends on accurate definition of underlying etiology and identification of realistic treatment targets. Close follow up of treated patients in terms of efficacy and safety of treatment as well as evaluation of treatment response with identification of responsible factors and implementing appropriate dose adjustment in case of insufficient treatment response are critical factors in opimizing growth hormone (GH) therapy. In this review, optimal treatment of GHD has been evaluated in terms of targets of GH replacement therapy, factors affecting treatment response, growth response prediction models, assessment of insufficient treatment response, monitorization, and discontinuation of GH treatment.

Keywords: Growth hormone deficiency, growth hormone therapy, treatment optimization

DOI :10.5222/j.child.2014.148 IUP :10.5222/j.child.2014.148 Full Text (PDF)

Çocukluk Çağı Büyüme Hormonu Eksikliğinde Büyüme Hormonu Tedavisinin Optimizasyonu

Fatma Feyza Darendeliler

Büyüme hormonu eksikliğinde (BHE) tanı ve tedavi süreci oldukça zorlu olup, gerek tanı kriterleri gerekse hangi çocuklara tedavi verilmesi gerektiği konusunda henüz tam bir görüş birliği yoktur. Büyüme bozukluklarının optimal tedavisi etiyolojinin doğru tanılanması ve gerçekçi tedavi hedeflerinin belirlenmesi ile olası olup, tedavi altındaki hastaların etkililik ve güvenlilik açısından yakın izlemi, izlem sürecinde tedavi yanıtı değerlendirilerek yetersiz yanıt durumunda ilgili faktörlerin belirlenmesi ve uygun doz ayarlamalarının yapılması BH tedavisinin optimizasyonunun kritik bileşenlerindendir. Bu derleme makalesinde, büyüme hormonu (BH) yerine koyma tedavisi hedefleri ve tedavi yanıtını etkileyen faktörler, büyüme yanıtı öngörü modelleri, yetersiz tedavi yanıtının değerlendirilmesi, BH tedavisi izlemi ve BH tedavisinin kesilmesi açısından değerlendirilmektedir.

Keywords: Büyüme hormonu eksikliği, büyüme hormonu tedavisi, tedavi optimizasyonu

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Darendeliler, F.F. (2014). Optimizing Growth Hormone Therapy in Chilhood Growth Hormone Defiency. Journal of Child, 14(4), 148-155. https://doi.org/10.5222/j.child.2014.148

AMA

Darendeliler F F. Optimizing Growth Hormone Therapy in Chilhood Growth Hormone Defiency. Journal of Child. 2014;14(4):148-155. https://doi.org/10.5222/j.child.2014.148

ABNT

Darendeliler, F.F. Optimizing Growth Hormone Therapy in Chilhood Growth Hormone Defiency. Journal of Child, [Publisher Location], v. 14, n. 4, p. 148-155, 2014.

Chicago: Author-Date Style

Darendeliler, Fatma Feyza,. 2014. “Optimizing Growth Hormone Therapy in Chilhood Growth Hormone Defiency.” Journal of Child 14, no. 4: 148-155. https://doi.org/10.5222/j.child.2014.148

Chicago: Humanities Style

Darendeliler, Fatma Feyza,. “Optimizing Growth Hormone Therapy in Chilhood Growth Hormone Defiency.” Journal of Child 14, no. 4 (Apr. 2024): 148-155. https://doi.org/10.5222/j.child.2014.148

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Darendeliler, FF 2014, 'Optimizing Growth Hormone Therapy in Chilhood Growth Hormone Defiency', Journal of Child, vol. 14, no. 4, pp. 148-155, viewed 24 Apr. 2024, https://doi.org/10.5222/j.child.2014.148

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Darendeliler, F.F. (2014) ‘Optimizing Growth Hormone Therapy in Chilhood Growth Hormone Defiency’, Journal of Child, 14(4), pp. 148-155. https://doi.org/10.5222/j.child.2014.148 (24 Apr. 2024).

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Darendeliler, Fatma Feyza,. “Optimizing Growth Hormone Therapy in Chilhood Growth Hormone Defiency.” Journal of Child, vol. 14, no. 4, 2014, pp. 148-155. [Database Container], https://doi.org/10.5222/j.child.2014.148

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Darendeliler FF. Optimizing Growth Hormone Therapy in Chilhood Growth Hormone Defiency. Journal of Child [Internet]. 24 Apr. 2024 [cited 24 Apr. 2024];14(4):148-155. Available from: https://doi.org/10.5222/j.child.2014.148 doi: 10.5222/j.child.2014.148

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Darendeliler, FatmaFeyza. “Optimizing Growth Hormone Therapy in Chilhood Growth Hormone Defiency”. Journal of Child 14/4 (Apr. 2024): 148-155. https://doi.org/10.5222/j.child.2014.148

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Optimizing Growth Hormone Therapy in Chilhood Growth Hormone Defiency

Çocukluk Çağı Büyüme Hormonu Eksikliğinde Büyüme Hormonu Tedavisinin Optimizasyonu

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