JAPANESE JOURNAL OF LEPROSY
Online ISSN : 1884-314X
Print ISSN : 1342-3681
ISSN-L : 1342-3681
IL-12 and IL-18 synergistically induce the bactericidal activity of murine peritoneal cells against M. leprae
Hiroko Nomaguchi, Nilufar Jahan, Bhairab Chandra Mandal, Yasuko Yogi, Kunio Kawatsu, Yusuke Yoshizawa, Haruki Okamura, Masahiko Makino
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Keywords: M. leprae, murine peritoneal cell, IL-12, IL-18, bactericidal activity
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2001 Volume 70 Issue 3 Pages 113-119

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Abstract

We examined the effect of IL-12 and IL-18 on bactericidal activities of mouse peritoneal cell (PC) against Mycobacterium leprae (M. leprae). We demonstrated that IL-12 and IL-18 synergistically induced the NO-dependent bactericidal activity of PC by stimulating Natural Killer (NK) cells and T-cells through IFN-γ production. IL-12 and IL-18 induced host cell death through NK-cells and T-cells. Therefore, IL-12 and IL-18 play an important role on direct killing of intracellular M. leprae and on indirect killing of them through inducing host cell death.

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