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The Effect of Zinc Supplementation on Plasma Melatonin and Kisspeptin Levels in Rams

Year 2022, Volume: 62 Issue: 1, 31 - 36, 01.07.2022

Halil Harman Behiç Serpek

https://doi.org/10.46897/livestockstudies.1120128

Abstract

The study that researched the effect of zinc added to the rations of rams on kisspeptin and melatonin levels was conducted on 2 years old 12 Kivircik crossbreed rams (6 control, 6 experimental) for 1 year. In addition to the ad libitum dry alfalfa straw, it was given mixed feed (barley, salt and vitamin-mineral mixture as standard) supplemented with 25 mg/kg/ DM ZnO, for the control group and 125 mg/kg/ DM ZnO for experimental group per day. During the study, blood samples were taken once a month and kisspeptin and melatonin levels were measured with ELISA in plasmas obtained from blood samples. Melatonin levels were found to be between 62.8-164.5 ng/L in experimental group and 22.1-105.9 ng/L in control group. Kisspeptin levels were determined to be between 209.8-514.2 ng/L in experimental group and 92.6-356.6 ng/L in control group. Zinc supplementations showed numerical increases in kisspeptin and melatonin levels but because of the individual variations, no statistical significance was found (P > 0.05).

Keywords

Kisspeptin Melatonin Zinc Ram

References

  • Ancel, C., Bentsen, A.H., Sebert, M.E., Tena-Sempere, M., Mikkelsen, J.D., & Simonneaux, V. (2012). Stimulatory effect of RFRP-3 on the gonadotrophic axis in the male Syrian hamster: The exception proves the rule. Endocrinology, 153: 1352-1363. https://doi.org/10.1210/en. 2011-1622
  • Alvarado, M.V., Carrillo, M., & Felip, A. (2015). Melatonin-induced changes in kiss/gnrh gene expression patterns in the brain of male sea bass during spermatogenesis. Comparative Biochemistry Physiology, 185, 69-79. https://doi.org/10.101 6/j. cbpa.2015.03.010
  • Baltacı, A.K., Moğulkoç, R., Bediz, C.S., Kul, A., & Ugur A. (2003). Pinealectomy and zinc deficiency have opposite effects on thyroid hormones in rats. Endocrine Research, 29(4), 473-81. https:// doi.org/10.1081/erc-120026953
  • Baltacı, A.K., Mogulkoc R. (2017). Leptin, NPY, melatonin and zinc levels in experimental hypothyroidism and hyperthyroidism: The relation to zinc. Biochemical Genetics, 55(3), 223-233. https://doi.org/10.1007 /s10528-017 -9791-z
  • Bediz, C.S., Baltaci, A.K., & Moğulkoç, R. (2003). Both zinc deficiency and supplementation affect plasma melatonin levels in rats. Acta Physiologica Hungarica, 90(4), 335-339. https://doi.org/10. 1556/APhysiol.90.2003.4.7
  • Buchanan, K.L., Yellon, S.M. (1991). Delayed puberty in the male djungarian hamster: Effect of short photoperiod melatonin treatment on the GnRH neuronal system. Neuroendocrinology, 54(2), 96-102. https://doi.org/10.1159/00012 58
  • Carnevalli, O., Gioacchini, G., Maradonna, F., Olivotto, I., & Migliarini, B. (2011). Melatonin induces follicle maturation in Danio rerio. Plos one 6, e19978. https://doi.org/ 10.1371/journal.pone.0019978
  • Clarke, I.J., Qi, Y., Puspita, I., & Smith, J,T. (2009a). Evidence that RF-amid related peptides are inhibitors of reproduction in mammals. Frontiers in Neuroendocrinology, 30(3), 371-78. https://doi.org/10.1016/j.yfrne. 2009.04. 001.
  • Clarke, I.J., Smith, J.T., Caraty, A., Goodman, R.L., & Lehman M.N. (2009b). Kisspeptin and seasonality in sheep. Peptides, 30(1), 154-163. https://doi.org/10.1016/j.peptides.2008.08.022
  • Goodman, R.L., Jansen, H.T., Billings, H.J., Coolen, L.M., & Lehman, M.N. (2010). Neural systems mediating seasonal breeding in the ewe. Journal of Neuroendocrinology, 22(7), 674- 681. https://doi. org/10.1111/j.1365-2826. 2010.02014.x
  • Hanlein, G.F.W., Anke, M. (2011). Mineral and trace element research in goats- A Review. Small Ruminant Research, 95, 2-19. https://doi. org/10.1016/j.smallrumres.2010.11.00
  • Irwig, M.S., Fraley, G.S., Smith, J.T., Acohido, B.V, Popa, S.M, Cunningham, M.J., Gottsch, M.L., Clifton, D.K., & Steiner, R.A. (2004). Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of Kiss1 mRNA in the male rat. Neuroendocrinology, 80(4): 264-272. https://doi. org/10.1159/000083140.
  • Lee, J.H., Miele, M.E., Hicks, D.J., Phillips, K.K., Trent, J.M., Weissman, B.E., & Welch, D.R. (1996). Kiss1, a novel human malignant melanoma metastasis-suppressor gene. Journal of the National Cancer Institute, 88,1731-37. https://doi.org/10.1093/ jnci/88.23.1731
  • Ohtaki, T., Shintani, Y., Honda, S., Matsumoto, H., Hori, A., Kanehashi, K., Terao, Y., Kumano, S., Takatsu, Y., Masuda, Y., Ishibashi, Y., Watanabe, T., Asada, M., Yamada, T., Suenaga, M., Kitada, C., Usuki, S., Kurokawa, T., Onda, H., Nishimura, O., & Fujino, M. 2001. Metastasis suppressor gene Kiss1 encodes peptide ligand of a G-protein-coupled receptor. Nature, 411(6837), 613-617. https://doi.org/10. 1038/35079135
  • Öztürk, G., Akbulut, K.G., & Afrasyap L. (2008). Age-related changes in tissue and plasma zinc levels: modulation by exogenously administered melatonin. Experimental Aging Research, 34(4), 453-462. https://doi.org/10.1080/0361 07308022 71922
  • Revel, F.G., Saboureau, M., Masson-Pévet, M., Pévet, P., & Mikkelsen, J.D. (2006). Kisspeptin mediates the photoperiodic control of reproduction in hamsters. Current Biology, 16, 1730-1735. https://doi.org/10.1016/j.cub.2006.07.025
  • Quershi, I.Z., Abbas, Q. (2013). Modulation of testicular and whole blood trace element concentrations in conjunction with testosterone release following kisspeptin administration in male rabbits (Oryctolagus cuniculus). Biological Trace Element Research, 154, 210-16. https://doi.org/10.1007/s 12011-013-9720-x
  • Song, Y.M., Chen, M.D. (2009). Effects of melatonin administration on plasma leptin concentration and adipose tissue leptin secretion in mice. Acta Biologica Hungarica, 60, 399-407. https://doi. org/10.1556/ABiol.60.2009.4.6
  • Viguie, C., Caraty, A., Locatelli, A., & Malpaux, B. (1995). Regulation of luteinizing hormone-releasing hormone (LHRH) secretion by melatonin in theewe. II. Changes in N-methyl-D,L- aspartic acid-induced LHRH release during the stimulation of luteinizing hormone secretion by melatonin. Biology of Reproduction, 52(5), 1156-1161. https://doi.org/ 10.1095/biolreprod52.5.1156
  • Wagner, G.C., Johnston, J.D., Clarke, I.J., Lincoln, G.A., & Hazlerigg, D.G. (2008). Redefining the limits of day length responsiveness in a seasonal mammal. Endocrinology, 149, 32-39. https://doi.org/10. 1210/en.2007-0658

Year 2022, Volume: 62 Issue: 1, 31 - 36, 01.07.2022

Halil Harman Behiç Serpek

https://doi.org/10.46897/livestockstudies.1120128

Abstract

References

  • Ancel, C., Bentsen, A.H., Sebert, M.E., Tena-Sempere, M., Mikkelsen, J.D., & Simonneaux, V. (2012). Stimulatory effect of RFRP-3 on the gonadotrophic axis in the male Syrian hamster: The exception proves the rule. Endocrinology, 153: 1352-1363. https://doi.org/10.1210/en. 2011-1622
  • Alvarado, M.V., Carrillo, M., & Felip, A. (2015). Melatonin-induced changes in kiss/gnrh gene expression patterns in the brain of male sea bass during spermatogenesis. Comparative Biochemistry Physiology, 185, 69-79. https://doi.org/10.101 6/j. cbpa.2015.03.010
  • Baltacı, A.K., Moğulkoç, R., Bediz, C.S., Kul, A., & Ugur A. (2003). Pinealectomy and zinc deficiency have opposite effects on thyroid hormones in rats. Endocrine Research, 29(4), 473-81. https:// doi.org/10.1081/erc-120026953
  • Baltacı, A.K., Mogulkoc R. (2017). Leptin, NPY, melatonin and zinc levels in experimental hypothyroidism and hyperthyroidism: The relation to zinc. Biochemical Genetics, 55(3), 223-233. https://doi.org/10.1007 /s10528-017 -9791-z
  • Bediz, C.S., Baltaci, A.K., & Moğulkoç, R. (2003). Both zinc deficiency and supplementation affect plasma melatonin levels in rats. Acta Physiologica Hungarica, 90(4), 335-339. https://doi.org/10. 1556/APhysiol.90.2003.4.7
  • Buchanan, K.L., Yellon, S.M. (1991). Delayed puberty in the male djungarian hamster: Effect of short photoperiod melatonin treatment on the GnRH neuronal system. Neuroendocrinology, 54(2), 96-102. https://doi.org/10.1159/00012 58
  • Carnevalli, O., Gioacchini, G., Maradonna, F., Olivotto, I., & Migliarini, B. (2011). Melatonin induces follicle maturation in Danio rerio. Plos one 6, e19978. https://doi.org/ 10.1371/journal.pone.0019978
  • Clarke, I.J., Qi, Y., Puspita, I., & Smith, J,T. (2009a). Evidence that RF-amid related peptides are inhibitors of reproduction in mammals. Frontiers in Neuroendocrinology, 30(3), 371-78. https://doi.org/10.1016/j.yfrne. 2009.04. 001.
  • Clarke, I.J., Smith, J.T., Caraty, A., Goodman, R.L., & Lehman M.N. (2009b). Kisspeptin and seasonality in sheep. Peptides, 30(1), 154-163. https://doi.org/10.1016/j.peptides.2008.08.022
  • Goodman, R.L., Jansen, H.T., Billings, H.J., Coolen, L.M., & Lehman, M.N. (2010). Neural systems mediating seasonal breeding in the ewe. Journal of Neuroendocrinology, 22(7), 674- 681. https://doi. org/10.1111/j.1365-2826. 2010.02014.x
  • Hanlein, G.F.W., Anke, M. (2011). Mineral and trace element research in goats- A Review. Small Ruminant Research, 95, 2-19. https://doi. org/10.1016/j.smallrumres.2010.11.00
  • Irwig, M.S., Fraley, G.S., Smith, J.T., Acohido, B.V, Popa, S.M, Cunningham, M.J., Gottsch, M.L., Clifton, D.K., & Steiner, R.A. (2004). Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of Kiss1 mRNA in the male rat. Neuroendocrinology, 80(4): 264-272. https://doi. org/10.1159/000083140.
  • Lee, J.H., Miele, M.E., Hicks, D.J., Phillips, K.K., Trent, J.M., Weissman, B.E., & Welch, D.R. (1996). Kiss1, a novel human malignant melanoma metastasis-suppressor gene. Journal of the National Cancer Institute, 88,1731-37. https://doi.org/10.1093/ jnci/88.23.1731
  • Ohtaki, T., Shintani, Y., Honda, S., Matsumoto, H., Hori, A., Kanehashi, K., Terao, Y., Kumano, S., Takatsu, Y., Masuda, Y., Ishibashi, Y., Watanabe, T., Asada, M., Yamada, T., Suenaga, M., Kitada, C., Usuki, S., Kurokawa, T., Onda, H., Nishimura, O., & Fujino, M. 2001. Metastasis suppressor gene Kiss1 encodes peptide ligand of a G-protein-coupled receptor. Nature, 411(6837), 613-617. https://doi.org/10. 1038/35079135
  • Öztürk, G., Akbulut, K.G., & Afrasyap L. (2008). Age-related changes in tissue and plasma zinc levels: modulation by exogenously administered melatonin. Experimental Aging Research, 34(4), 453-462. https://doi.org/10.1080/0361 07308022 71922
  • Revel, F.G., Saboureau, M., Masson-Pévet, M., Pévet, P., & Mikkelsen, J.D. (2006). Kisspeptin mediates the photoperiodic control of reproduction in hamsters. Current Biology, 16, 1730-1735. https://doi.org/10.1016/j.cub.2006.07.025
  • Quershi, I.Z., Abbas, Q. (2013). Modulation of testicular and whole blood trace element concentrations in conjunction with testosterone release following kisspeptin administration in male rabbits (Oryctolagus cuniculus). Biological Trace Element Research, 154, 210-16. https://doi.org/10.1007/s 12011-013-9720-x
  • Song, Y.M., Chen, M.D. (2009). Effects of melatonin administration on plasma leptin concentration and adipose tissue leptin secretion in mice. Acta Biologica Hungarica, 60, 399-407. https://doi. org/10.1556/ABiol.60.2009.4.6
  • Viguie, C., Caraty, A., Locatelli, A., & Malpaux, B. (1995). Regulation of luteinizing hormone-releasing hormone (LHRH) secretion by melatonin in theewe. II. Changes in N-methyl-D,L- aspartic acid-induced LHRH release during the stimulation of luteinizing hormone secretion by melatonin. Biology of Reproduction, 52(5), 1156-1161. https://doi.org/ 10.1095/biolreprod52.5.1156
  • Wagner, G.C., Johnston, J.D., Clarke, I.J., Lincoln, G.A., & Hazlerigg, D.G. (2008). Redefining the limits of day length responsiveness in a seasonal mammal. Endocrinology, 149, 32-39. https://doi.org/10. 1210/en.2007-0658
There are 20 citations in total.

Details

Primary Language English
Subjects Zootechny (Other)
Journal Section 62-1
Authors

Halil Harman This is me

Behiç Serpek This is me

Publication Date July 1, 2022
Published in Issue Year 2022 Volume: 62 Issue: 1

Cite

APA Harman, H., & Serpek, B. (2022). The Effect of Zinc Supplementation on Plasma Melatonin and Kisspeptin Levels in Rams. Livestock Studies, 62(1), 31-36. https://doi.org/10.46897/livestockstudies.1120128
AMA Harman H, Serpek B. The Effect of Zinc Supplementation on Plasma Melatonin and Kisspeptin Levels in Rams. Livestock Studies. July 2022;62(1):31-36. doi:10.46897/livestockstudies.1120128
Chicago Harman, Halil, and Behiç Serpek. “The Effect of Zinc Supplementation on Plasma Melatonin and Kisspeptin Levels in Rams”. Livestock Studies 62, no. 1 (July 2022): 31-36. https://doi.org/10.46897/livestockstudies.1120128.
EndNote Harman H, Serpek B (July 1, 2022) The Effect of Zinc Supplementation on Plasma Melatonin and Kisspeptin Levels in Rams. Livestock Studies 62 1 31–36.
IEEE H. Harman and B. Serpek, “The Effect of Zinc Supplementation on Plasma Melatonin and Kisspeptin Levels in Rams”, Livestock Studies, vol. 62, no. 1, pp. 31–36, 2022, doi: 10.46897/livestockstudies.1120128.
ISNAD Harman, Halil - Serpek, Behiç. “The Effect of Zinc Supplementation on Plasma Melatonin and Kisspeptin Levels in Rams”. Livestock Studies 62/1 (July 2022), 31-36. https://doi.org/10.46897/livestockstudies.1120128.
JAMA Harman H, Serpek B. The Effect of Zinc Supplementation on Plasma Melatonin and Kisspeptin Levels in Rams. Livestock Studies. 2022;62:31–36.
MLA Harman, Halil and Behiç Serpek. “The Effect of Zinc Supplementation on Plasma Melatonin and Kisspeptin Levels in Rams”. Livestock Studies, vol. 62, no. 1, 2022, pp. 31-36, doi:10.46897/livestockstudies.1120128.
Vancouver Harman H, Serpek B. The Effect of Zinc Supplementation on Plasma Melatonin and Kisspeptin Levels in Rams. Livestock Studies. 2022;62(1):31-6.
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