13th World Congress for Laser Dentistry

26-28, April 2012

Barcelona, Spain

Meeting Abstract

Sponsors: World Federation for Laser Dentistry

- Oral Presentation 61

TITLE: Pilot in vitro study for LLLT with Nd:YAG laser in dental extractions in rats under zoledronic acid and dexamethasone administration.

AUTHORS: Vescovi P, Merigo E, Corradi D, Maestri R, Fornaini C, Nammour S.

Unit of Oral Pathology, Oral Medicine and Laser-Assisted Oral Surgery, Pathology section – University of Parma – Italy. University of Liège – Belgium

SOURCE: Med Oral Patol Oral Cir Bucal. 2012 May 1;17(Supplement1):S61.

* doi:10.4317/medoral.17643560

http://dx.doi.org/10.4317/medoral.17643560

Abstract

Introduction: Bisphosphonates due to effects on bone turnover and antiangiogenic properties are linked to osteonecrosis of the jaws (ONJ). Low Level Laser Therapy (LLLT) can be effective in bone and mucosal repair after dental extractions.

Aim of the study: To analyze the effects of dental extractions and Nd:YAG laser biostimulation in rats under zoledronic acid and steroid therapy with a clinical and histomorphometric analysis.

Material and Methods: Thirty Wistar rats were randomly subdivided into three different groups: experimental group treated with zoledronic acid, experimental group treated with zoledronic acid plus Dexamethasone, control group without pharmacological treatment. After six weeks of pharmacological treatment, maxillary first molars teeth were bilaterally extracted and all groups received LLLT in each left maxillary side immediately after tooth extraction and then three times/week until the sacrifice. LLLT was performed with a Nd:YAG laser (Fidelis, Fotona -1.25 W, 15 Hz, VSP, 60 sec, 5 applications. Degree of local inflammation, surface epithelium healing, connective tissue and bone regeneration were evaluated.

Results: Three days after the extraction, soft and hard tissues healing was better on laser side, without a significant statistical difference. Inflammation degree was significantly lower on the laser sides (p=0,0384).

Conclusions: LLLT maybe a help during the early sta-ges of recovery after surgical procedures under zoledronic acid treatment.