Open Access, Peer-reviewed
pISSN 2288-6575
eISSN 2288-6796
    J Korean Surg Soc. 2010 Jun;78(6):385-389. Korean.
    Published online Jun 07, 2010.
    https://doi.org/10.4174/jkss.2010.78.6.385
    Copyright © 2010 The Korean Surgical Society
    Original Article

    Antimicrobial Prophylaxis Using a 2nd Generation Cephalosporin after Laparoscopic Colorectal Resection: A Randomized Trial of 1-day vs. 3-day

    Han Deok Kwak, M.D., Dong Jin Choi, M.D., Si Uk Woo, M.D., Jin Kim, M.D., Jun Won Um, M.D.,1 and Seon Hahn Kim, M.D.
      • Department of Surgery, Korea University Anam Hospital, Seoul, Korea.
      • 1Department of Surgery, Korea University Ansan Hospital, Ansan, Korea.
    • Corresponding author (Email: drkimsh@korea.ac.kr )
    Received December 11, 2009; Accepted March 08, 2010.

    Abstract

    Purpose

    We performed this study to compare 1-day group using a 2nd generation cephalsporin with 3-day group for evaluating hospital acquired infection.

    Methods

    The patients underwent laparoscopic colorectal surgery at Korea University Medical Center Anam Hospital, from August, 2007 to June, 2008. They were randomly allocated to 2 groups: 1-day or 3-day group. A 2nd generation cephalosporin was administered within 1 hour before surgery with 12-hour intervals. In cases of suspected infection, further studies were done to identify infection.

    Results

    The study included 154 patients (1-day group - 78, vs. 3-day group - 76). No differences were noted between the 2 groups in age, body mass index, smoking, diabetes mellitus, corticosteroid-use were noted. Gender (P=0.011) and mean operative time (P=0.047) between the 2 groups were different. The preventive rates of infection were 87.18% in the 1-day group compared with 82.89% in the 3-day group (P=0.456).

    Conclusion

    Our prospective randomized control study concluded that there were no differences between the 1-day and 3-day group in hospital acquired infection. We could come to the conclusion that 1-day antimicrobial agent in laparoscopic colorectal surgery would be adequate in preventing infection.

    Keywords
    Antimicrobial prophylaxis; Monotherapy; Laparoscopic colorectal surgery; Surgical site infection; Hospital acquired infection

    Tables

    Table 1
    Clinical characteristics

    Table 2
    Indications for surgery and selected operative details

    Table 3
    Postoperative variables

    Table 4
    Hospital acquired infection and results of 1-day vs 3-day group

    References

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    MeSH Terms
    Academic Medical Centers
    Body Mass Index
    Colorectal Surgery
    Diabetes Mellitus
    Humans
    Korea
    Operative Time
    Prospective Studies
    Smoke
    Smoking
    Metrics
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