Open Access, Peer-reviewed
pISSN 2288-0402
eISSN 2288-0410
    Allergy Asthma Respir Dis. 2014 May;2(2):114-121. Korean.
    Published online May 31, 2014.
    https://doi.org/10.4168/aard.2014.2.2.114
    © 2014 The Korean Academy of Pediatric Allergy and Respiratory Disease; The Korean Academy of Asthma, Allergy and Clinical Immunology
    Original Article

    Correlation between serum 25-hydroxyvitamin D levels and severity of atopic dermatitis in children

    Young Hye Shin, Jong Ha Park, Myoung Soon Sung and Sung Won Kim
      • Department of Pediatrics, Busan St. Mary's Hospital, Busan, Korea.
    • Correspondence to: Sung Won Kim. Department of Pediatrics, Busan St. Mary's Hospital, 25-14 Yongho-ro 232beon-gil, Nam-gu, Busan 608-838, Korea. Tel: +82-51-933-7981, Fax: +82-51-936-7531, Email: sbdph1@daum.net
    Received July 15, 2013; Revised August 27, 2013; Accepted August 30, 2013.

    This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/).

    Abstract

    Purpose

    Vitamin D deficiency has been suggested to play a role in the pathogenesis of atopic dermatitis. In addition, inverse correlationship between serum 25-hydroxyvitamin D concentration and severity of atopic dermatitis has been suggested.

    Methods

    Clinical and laboratory parameters including serum 25-hydroxyvitamin D level and serum total IgE of 251 patients with atopic dermatitis who were 13 months to 18 years were measured. Severity of atopic dermatitis was assessed with SCORing Atopic Dermatitis (SCORAD) index. Statistical analysis was performed using Pearson correlation coefficient, one-way analysis of variance test and chi-square test.

    Results

    Among 251 patients, vitamin D deficiency (25-hydroxyvitamin D<20 ng/mL, group 1) was present in 76 subjects (30.3%), vitamin D insufficiency (25-hydroxyvitamin D 20-29 ng/mL, group 2) was present in 101 (40.2%), and vitamin D sufficiency (25-hydroxyvitamin D≥30 ng/mL, group 3) was present in 74 (29.5%). There was a statistically significant inverse correlation between serum concentration of 25-hydroxyvitamin D and values of SCORAD index (R=-0.24, P<0.000). Serum concentration of 25-hydroxyvitamin D were inversely correlated with total IgE (R=-0.29, P<0.000), and age (R=-0.49, P<0.000).

    Conclusion

    The results from this study indicate that serum concentration of 25-hydroxyvitamin D is inversely correlated with clinical severity of atopic dermatitis in children.

    Keywords
    Atopic dermatitis; 25-hydroxyvitamin D; SCORAD index

    Figures

    Fig. 1
    Correlation of 25-hydroxyvitamin D with age (A), SCORing Atopic Dermatitis (SCORAD) index (B), total immunoglobulin E (IgE) (C), and C-reactive protein (CRP) (D). P<0.05 is statistically significant.

    Fig. 2
    Serum immunoglobulin E (IgE) (A), age (B), SCORing Atopic Dermatitis (SCORAD) index (C) according to the groups (group 1, 25-hydroxyvitamin D<20 ng/mL; group 2, 25-hydroxyvitamin D, 20-29 ng/mL; group 3, 25-hydroxyvitamin D≥30 ng/mL). Horizontal lines indicate mean values. P<0.05 is statistically significant.

    Tables

    Table 1
    Clinical characteristics and laboratory findings of all patients

    Table 2
    Comparison of characteristics and laboratory findings in study groups

    Table 3
    25-Hydroxyvitamin D and SCORAD index according to the seasons

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    MeSH Terms
    Child*
    Dermatitis, Atopic*
    Humans
    Immunoglobulin E
    Vitamin D
    Vitamin D Deficiency
    Metrics
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