Bratislava Medical Journal Vol.117, No.10, p.562-570, 2016
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Title: Conservative versus invasive treatment in hypertrophic obstructive cardiomyopathy: an echocardiography study |
Author: T. Honek, J. Krejci, J. Machal, L. Groch, J. Sitar, J. Meluzin, L. Spinarova |
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Abstract: AIM AND METHODS: The aim of our study was to compare the development of echocardiographic parameters and functional status of patients with hypertrophic obstructive cardiomyopathy (HOCM) treated conservatively (n = 41) or by alcohol septal ablation (ASA; n = 39). RESULTS: Left ventricular outflow tract gradient (LVOTG) decreased in the first year by 53.7±36.4 mmHg in ASA group versus 5.5±47.1 mmHg in conservatively treated group (p<0.001), in the third year by 53.1±41.4 mmHg versus 23.9±42.7 mmHg (p = NS) and in the fifth year, the reduction of LVOTG was 52.1±44.5 mmHg in ASA group and 3.0±63.2 mmHg in conservatively treated group (p<0.05). Change in NYHA class in the first year was –1.1±0.4 versus 0.1±0.5, in the third year –1.0±0.6 versus 0.1±0.4 and in the fifth year –0.8±0.5 versus 0.1±0.4 (all p<0.001). CONCLUSION: Our results showed for the first time that decline of LVOTG after ASA creates a favorable left ventricle remodeling and leads to significant improvement of functional status of HOCM patients in comparison with conservative treatment (Tab. 3, Fig. 2, Ref. 42).
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Keywords: hypertrophic obstructive cardiomyopathy, alcohol septal ablation, conservative treatment, invasive treatment, echocardiography |
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Published online: 07-Nov-2016
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Year: 2016, Volume: 117, Issue: 10 |
Page From: 562, Page To: 570 |
doi:10.4149/BLL_2016_110
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