Initial clinical experience with ⁶⁸Ga-DOTA-NOC prepared using ⁶⁸Ga from nanoceria-polyacrylonitrile composite sorbent-based ⁶⁸Ge/⁶⁸Ga generator and freeze-dried DOTA-NOC kits

 

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Somatostatin receptor positron emission tomography–computed tomography (PET/CT) with ⁶⁸Ga-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) peptides have become an indispensable part of disease assessment in patients with neuroendocrine tumors and forms the basis of personalized therapy with peptide receptor-based radionuclide therapy. With growing utilization of PET/CT in developing countries, availability of the indigenous GMP-certified ⁶⁸Ge/⁶⁸Ga generators is expected to further promote cost-effective molecular imaging service to the cancer patients. We present our initial clinical experience in 32 patients injected with ⁶⁸Ga-DOTA-NOC prepared using ⁶⁸Ga eluted from Bhabha Atomic Research Centre nanoceria-polyacrylonitrile sorbent-based ⁶⁸Ge/⁶⁸Ga generator and freeze-dried DOTA-NOC cold kits.

Publication History

Article published online:
18 May 2022

© 2017. Sociedade Brasileira de Neurocirurgia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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