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CC BY-NC-ND 4.0 · World J Nucl Med 2014; 13(02): 128-131
DOI: 10.4103/1450-1147.139144
Original article

Impact of the Point Spread Function on Maximum Standardized Uptake Value Measurements in Patients with Pulmonary Cancer

S Gellee
Department of Radiology, Toulouse University Hospital, Toulouse 31000
,
J Page
1   Department of Nuclear Medicine, Royal Free Hospital, London, NM3 2QG
,
B Sanghera
2   Department of PET/CT, Paul Strickland Scanner Centre, Northwood, Middlesex, HA6 2RN, UK
,
P Payoux
3   Department of Nuclear Medicine, Toulouse University Hospital, Toulouse 31000
,
Thomas Wagner
1   Department of Nuclear Medicine, Royal Free Hospital, London, NM3 2QG
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Maximum standardized uptake value (SUVmax) from fluorodeoxyglucose (FDG) positron emission tomography (PET) scans is a semi quantitative measure that is increasingly used in the clinical practice for diagnostic and therapeutic response assessment purposes. Technological advances such as the implementation of the point spread function (PSF) in the reconstruction algorithm have led to higher signal to noise ratio and increased spatial resolution. The impact on SUVmax measurements has not been studied in clinical setting. We studied the impact of PSF on SUVmax in 30 consecutive lung cancer patients. SUVmax values were measured on PET-computed tomography (CT) scans reconstructed iteratively with and without PSF (respectively high-definition [HD] and non-HD). HD SUVmax values were significantly higher than non-HD SUVmax. There was excellent correlation between HD and non-HD values. Details of reconstruction and PSF implementation in particular have important consequences on SUV values. Nuclear Medicine physicians and radiologists should be aware of the reconstruction parameters of PET-CT scans when they report or rely on SUV measurements.

Keywords

Fluorodeoxyglucose positron emission tomography-computed tomography - lung cancer - maximum standardized uptake value - point spread function - quantification


Publication History

Article published online:
23 May 2022

© 2014. Sociedade Brasileira de Neurocirurgia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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