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HomeJournal of Biomimetics, Biomaterials and...Journal of Biomimetics, Biomaterials and...Bone Tissue Response in a Metallic Bone...

Bone Tissue Response in a Metallic Bone Architecture Microstructure

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Abstract:

Porous metallic structures have been developed to mimic the natural bone architecture, having interconnected porosity, disposing enough room to cell migration, anchoring, vascularization, nourishing and proliferation of new bone tissue. Research involving porous titanium has been done with purpose to achieve desirable porosity and increasing of bone-implant bond strength interface. Samples of titanium were prepared by powder metallurgy (PM) with addition of different natural polymers (cornstarch, rice starch, potato starch and gelatin) at proportion of 16wt%. In aqueous solution the hydrogenated metallic powder (TiH₂) and the polymer were mixed, homogenized and frozen in molds near net shape. The water was removed in kiln and the polymer by thermal treatment in air- (350°C/1h) before sintering in high-vacuum (1300°C/1h). The biological evaluation was performed by in vivo test in rabbits. Histological analysis was performed by scanning electron microscopy (SEM), energy dispersive spectroscopy (SEM-EDS) and fluorescence microscopy (FM). The processing methodologies using natural low cost additives propitiate the production of porous metallic implants in a simplified manner, with different porosities, proper porosity degree (40%), distribution, and maximum pore size of 80 μm to 220 μm depending of natural polymer used. The samples added with rice starch, presented the most similar structure organization when compared to the bone tissue microstructure organization of the trabecular bone. All implants osseointegrated, the pore microarchitecture and its interconnected network allowed bone ingrowth in all pore sizes, but the continuous bone maturation occurred in pores bigger than 80 μm.

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Journal of Biomimetics, Biomaterials and Biomedical Engineering Vol. 20

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Journal of Biomimetics, Biomaterials and Biomedical Engineering (Volume 20)

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73-85

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https://doi.org/10.4028/www.scientific.net/JBBBE.20.73

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Online since:

June 2014

Authors:

Tamiye Simone Goia*, Kalan Bastos Violin, Carola Gomez Ágreda, José Carlos Bressiani, Ana Helena de Almeida Bressiani

Keywords:

Bone Microstructure, Natural Polymers, Porosity, Titanium

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* - Corresponding Author

[1] R.L. Oréfice, M.M. Pereira, H.S. Mansur, Biomateriais – Fundamentos e Aplicações, first ed., Ed. Cultura Médica, Rio de Janeiro, (2006).

[2] D.A. Puelo, A. Nanci, Undestanding and controlling the bone-implant interface, Biomaterials. 20 (1999) 2311-2321.

[3] J.E. Lemons, Biomaterials, biomechanics, tissue healing, and immediate-function dental implants, J. Oral Implantol. 30 (2004) 318-324.

DOI: 10.1563/0712.1

[4] R.Z. Legeros, R.G. Craig, Strategies to affect bone remodeling: osteointegration. J. Bone Miner. Res. 8 (1993) 583-596.

DOI: 10.1002/jbmr.5650081328

[5] M. Weinlaender, Bone growth around dental implants, Dent. Clin. North. Am. 35 (1991) 585-601.

DOI: 10.1016/s0011-8532(22)00860-6

[6] L.C. Junqueira, J. Carneiro, Histologia básica, eighth ed., Guanabara Koogan, Rio de Janeiro, (1995).

[7] X. Liu, P.K. Chu, C. Ding, Surface modification of titanium, titanium alloys, and related materials for biomedical applications, Mat. Science Eng. R. 47 (2004) 49-121.

DOI: 10.1016/j.mser.2004.11.001

[8] S. Franz, S. Rammelt, D. Scharnweber, J.C. Simon, Immune responses to implants - A review of the implications for the design of immunomodulatory biomaterials, Biomat. 32 (2011) 1-18.

DOI: 10.1016/j.biomaterials.2011.05.078

[9] H. Shen, L.C. Brinson, Anumerical invention of porous titanium as orthopedic implant material. Mech. Mat. 8 (2011) 420-430.

[10] A.I. Itäla, H.O. Ylanen, C. Ekholm, K.H. Karlsson, H.T. Aro, Pore diameter of more than 100 micron is not requisite for bone ingrowth in rabbits. J. Biomed. Mater. Res. 58 (2001) 679-683.

DOI: 10.1002/jbm.1069

[11] S. Kujala, J. Ryhänen, A. Danilov, J. Tuukkanen, Effect of porosity on the osteointegration and bone ingrowth of a weight-bearing nickel–titanium bone graft substitute, Biomat. 24 (2003) 4691-4697.

DOI: 10.1016/s0142-9612(03)00359-4

[12] G. Ryan, A. Pandit, D.P. Apatsidis, Fabrication methods of porous metals for use in orthopaedic applications, Biomat. 27 (2006) 2651-2670.

DOI: 10.1016/j.biomaterials.2005.12.002

[13] A. Laptev, M. Bram, H.P. Buchkkemer, D. Stover, Study of production route for titanium parts combining very high porosity and complex shape, Powder Metal. 47 (2004) 85-92.

DOI: 10.1179/003258904225015536

[14] J. Li, H. Liao, B. Fartash, L. Hermansson, T. Johnsson, Surface-dimpled commercially pure titanium implant and bone ingrowth, Biomat. 18 (1997) 691-696.

DOI: 10.1016/s0142-9612(96)00185-8

[15] M. Takemoto, S. Fujibayashi, M. Neo, J. Suzuki, T. Kokubo, T. Nakamura, Mechanical properties and osteoconductivity of porous bioactive titanium, Biomat. 26 (2005) 6014-6023.

DOI: 10.1016/j.biomaterials.2005.03.019

[16] H.E. Götz, M. Müller, A. Emmel, U. Holzwarth, R.G. Erben, R. Stangl, Effect of surface finish on the osseointegration of laser-treated titanium alloy implants, Biomat. 25 (2004) 4057–4064.

DOI: 10.1016/j.biomaterials.2003.11.002

[17] S.C.P. Cachinho, R.N. Correia, Titanium scaffolds for osteointegration: mechanical, in vitro and corrosion behavior, J. Mater. Sci: Mater. Med. 19 (2008) 451–457.

DOI: 10.1007/s10856-006-0052-7

[18] A.E. Aguikar Maya, D.R. Grana, A. Hazarabedian, G.A. Kokubo, M.I. Luppo, G. Vigna, Zr-Ti-Nb porous alloy for biomedical application, Mat. Science Eng. C. 32 (2011) 321-329.

DOI: 10.1016/j.msec.2011.10.035

[19] T.S. Goia, K.B. Violin, M. Yoshimoto, J.C. Bressiani, A.H.A. Bressiani, Osseointegration of Titanium Alloy Macroporous Implants Obtained by PM with Addition of Gelatin, Adv. Science Techn. 76 (2010) 259-263.

DOI: 10.4028/www.scientific.net/ast.76.259

[20] O.M. Ferri, T. Ebel, R. Bormann, Influence of surface quality and porosity on fatigue behaviour of Ti–6Al–4V components processed by MIM, Mat. Science Eng. A. 527 (2010) 1800–1805.

DOI: 10.1016/j.msea.2009.11.007

[21] J.C. Li, D. C Dunand, Mechanical properties of directionally freeze-cast titanium foams. Acta Mat. 59 (2011) 146-158.

DOI: 10.1016/j.actamat.2010.09.019

[22] P. Heinl, L. Müller, C. Körner, R.F. Singer, F.A. Müller, Cellular Ti–6Al–4V structures with interconnected macro porosity for bone implants fabricated by selective electron beam melting. Acta Biomat. 4 (2008) 1536–1544.

DOI: 10.1016/j.actbio.2008.03.013

[23] F.E. Wiria, J.Y.M. Shyan, P.N. Lim, F.G.C. Wen, J.F. Yeo, T. Cao, Printing of Titanium implant prototype. Mat. Design. 31 (2010) S101–S105.

DOI: 10.1016/j.matdes.2009.12.050

[24] E. Gregorová, W. Pabst, I. Bohačenko, Characterization of different starch types for their application in ceramic processing, J. Eur. Ceram. Soc. 26 (2006) 1301-1309.

DOI: 10.1016/j.jeurceramsoc.2005.02.015

[25] T.S. Goia, K.B. Violin, J.C. Bressiani, A.H.A. Bressiani, Mimicking Bone Architecture in a Metallic Structure, Adv. Science Techn. 84 (2013) 7-12.

DOI: 10.4028/www.scientific.net/ast.84.7

[26] E. Gemelli, N.H.A. Camargo, Oxidation kinetics of commercially pure titanium, Rev. Matéria. 12 (2007) 525-531.

DOI: 10.1590/s1517-70762007000300014

[27] C.J. Hernandez , T.M. Keaveny, A biomechanical perspective on bone quality, Bone. 39 (2006) 1173–1181.

DOI: 10.1016/j.bone.2006.06.001

[28] D. Chappard, M. -F. Baslé, E. Legrand, M. Audran, Trabecular bone microarchitecture: A review, Morphologie. 92 (2008) 162—170.

DOI: 10.1016/j.morpho.2008.10.003

[29] C. Pautke, S. Vogt, K. Kreutzer, C. Haczek, G. Wexel, A. Kolk, A.B. Imhoff, H. Zitzelsberger, 5 S. Milz, T. Tischer, Characterization of eight different tetracyclines: advances in fluorescence bone labeling, J. Anat. 217 (2010) 76-82.

DOI: 10.1111/j.1469-7580.2010.01237.x