Paper Titles

Development of MTA/HAp Biomaterials for Use in Endodontics
p.7

Glass Ionomer Cement – Development and Characterization Microstructural
p.12

Biocompatibility of Dental Restorative Materials
p.19

Synthesis and Characterization of Ionic Crosslinked Chitosan Scaffolds
p.26

Evaluation of the Cytotoxic Potential Chitosan/Hydroxyapatite Biocomposites
p.30

Sterilization of Chitosan Membranes for Use as Biomaterial
p.35

Evaluation of the Terms of Use of Recycled Polymer Packaging Co-Extruded
p.41

Study of Non-Conformities of Hip Prosthesis Metal Front Standards
p.47

Scientific and Technological Study of the Modulus of Elasticity and Chemical Abnormalities of a Titanium Alloy and Stainless Steel Alloy Used in Hip Prosthesis
p.52

HomeMaterials Science ForumMaterials Science Forum Vol. 805Evaluation of the Cytotoxic Potential...

Evaluation of the Cytotoxic Potential Chitosan/Hydroxyapatite Biocomposites

Article Preview

Abstract:

The incorporation of calcium phosphate in a polymer matrix for composites production combines the flexibility of the polymers with the resistance, hardness and bioactivity of the inorganic phase. This study aimed to obtain rigid biocomposites using hydroxyapatite as mineral phase and chitosan as a polymer binder for the application as a biomaterial. To obtain the biocomposites, hydroxyapatite was added under constant stirring to a solution of chitosan in order to satisfy a 70:30 (HA/CS) ratio. XRD results showed no significant change in the profile of hydroxyapatite with the incorporation of chitosan. The analysis of scanning electron microscopy (SEM) of the biocomposite HA/CS, indicated that there was an excellent dispersion of HA particles in the polymeric matrix. Infrared Spectroscopy with Fourier Transform (FTIR) analysis proved an existing interaction between chitosan and hydroxyapatite. The biocompatibility of biocomposites HA/CS was confirmed by the MTT assay. It is considered that the present biocomposites are a promising biomaterial for trabecular bone grafting

You might also be interested in these eBooks

A Special Issue in Memory of Dr. Lucio Salgado

Info:

Periodical:

Materials Science Forum (Volume 805)

Pages:

30-34

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.805.30

Citation:

Cite this paper

Online since:

September 2014

Authors:

R.C.A. Leal*, I.V.S.R. Nascimento, M.V.L. Fook, R.C. Meira

Keywords:

Biocomposites, Chitosan, Hydroxyapatite (HA)

Export:

RIS, BibTeX

Price:

Permissions:

Request Permissions

* - Corresponding Author

[1] A. Uchida, N. Araki, Y. Shinto, H. Yoshikawa, E. Kurosaki and K. Ono: J. Bone Joint Surg. Vol. 72B (1990), p.298.

[2] M. Bohner: Injury Vol. 31 (2000), p.37.

[3] L.A. Santos: Desenvolvimento de Cimento de Fosfato de Cálcio Reforçado por Fibras para uso na Área Medico-Odontológica. Doutorado (Tese). Campinas, 2002. Universidade Estadual de Campinas (UNICAMP/FEM). (SP).

DOI: 10.47749/t/unicamp.2002.226008

[4] T. Volkmer: Obtenção e Caracterização de Hidroxiapatita Porosa pelo Metodo Gelcasting de Espumas para uso como Implantes. Mestrado (Dissertação). Porto Alegre, 2006. Universidade Federal do Rio Grande do Sul (UFRGS/MMMater). (RS).

DOI: 10.32467/issn.2175-3628v23n1a14

[5] L.C. Angelo: Síntese e Caracterização de nanocompósitos hidroxiapatita-gelatina obtidos pelo método de precipitação utilizando o método de Rietveld e Ivtf. Mestrado (Dissertação). Ponta Grossa, 2008. Universidade Estadual de Ponta Grossa (UEPG). (PR).

DOI: 10.5212/terraplural.v.15.2119754.036

[6] M. Sıvakumar and K.P. Rao: Preparation, Biomaterials Vol. 23 (2002), p.3175.

[7] D.A. Wahla and J.T. Czernuszka: Eur Cells Mater Vol. 11 (2006), p.43.

[8] V.M. Rusu, N. Chuen-How, M. Wilke, B. Tiersch, P. Fratzl and M.G. Peter: Biomaterials Vol. 26 (2005), p.5414.

DOI: 10.1016/j.biomaterials.2005.01.051

[9] Q. Hu, B. Li, M. Wang and J. Shen: Biomaterials Vol. 25 (2004), p.779.

[10] C. Muzzarelli and R.A.A. Muzzarelli: Journal of Inorganic Biochemistry Vol. 92 (2002), 89.

[11] M.C.M. Laranjeıra and V. Fávere: Química Nova Vol. 32 (2009), p.672.

[12] RAA. Muzzarelli: Carbohydr. Polym. Vol. 76 (2009), p.167.

[13] Finisie, R; Mellatie Josué, Atche; Fávere, Valfredo T; Laranjeira, C.M. Mauro Synthesis of Calcium-Phosphate and Chitosan Bioceramics for Bone Regeneration, (2000).

DOI: 10.1590/s0001-37652001000400006

[14] L. Jiang, Y. Li, X. Wang, L. Zhang, J. Wen and M. Gong: Carbohydrate Polymers Vol. 74 (2008), p.680.

[15] I. Manjubala, S. Scheler, J. Bossert, and K.D. Jandt: Acta Biomaterialia Vol. 2 (2006), p.75.

[16] V. Bispo: Estudo do Efeito da Reticulação por Genipin em suportes biocompatíveis de Quitosana-PVA. Belo Horizonte, (2009).