Influence of the Precipitation Temperature on Properties of Nanohydroxyapatite Powder for the Fabrication of Highly Porous Bone Scaffolds

Cristian Parisi; Francesca Gervaso; Francesca Scalera; Sanosh Kunjalukkal Padmanabhan; Concetta Nobile; P. Davide Cozzoli; Lucy Di Silvio; Alessandro Sannino

doi:10.4028/www.scientific.net/KEM.587.27

Paper Titles

Preface, Committees and Acknowledgements

Bio-Ceramics for the Next 25 Years: Challenges and Opportunities
p.3

Freeze-Casted Nanostructured Apatite Scaffold Obtained from Low Temperature Biomineralization of Reactive Calcium Phosphates
p.21

Influence of the Precipitation Temperature on Properties of Nanohydroxyapatite Powder for the Fabrication of Highly Porous Bone Scaffolds
p.27

Effects of Commercial Inert Glass (CIG) Addition on Mechanical and Microstructural Properties of Chicken Hydroxyapatite (CHA)
p.33

The Adsorption of Cytochrome C on Mesoporous Silica Coated Hydroxyapatite Ceramics in PBS Solution
p.39

Synthesis and Characterization of an Experimental Zn-Hydroxyapatite Powders with Application in Dentistry
p.43

Synthesis of Carbonate Apatite Foam Using β-TCP Foams as Precursors
p.52

HomeKey Engineering MaterialsKey Engineering Materials Vol. 587Influence of the Precipitation Temperature on...

Influence of the Precipitation Temperature on Properties of Nanohydroxyapatite Powder for the Fabrication of Highly Porous Bone Scaffolds

Abstract:

The aim of the present work is to study the influence of the precipitation temperature in the synthesis of nanohydroxyapatite (n-HAp) on the properties of the resulting n-HAp powder for the fabrication of highly porous scaffolds for bone tissue engineering. The n-HAp powder was obtained by a wet precipitation technique starting from calcium nitrate tetrahydrate (Ca (NO₃)₂*4H₂O) and phosphoric acid (H₃PO₄) at different temperatures: 10°C, 37°C and 50°C. Highly porous scaffolds were fabricated using the three different powders by the sponge replica method and sintering at 1300°C. Combined X-ray diffraction (XRD) and transmission electron microscopy (TEM) analyses on powders indicated that on increasing the precipitation temperature the formation of pure n-HAp is accelerated, without significant changes in particles morphology and size. Scaffolds characterized by high porosity (89%) and good compressive strength (0.53 MPa for n-HAp prepared at 37°C) were obtained. XRD analyses on sintered n-HAp confirmed the thermal stability of the material. Therefore, the as-synthesized n-HAp powder can be successfully used for the fabrication of highly porous scaffolds as bone substitutes.

You might also be interested in these eBooks

View Preview

Info:

Periodical:

Key Engineering Materials (Volume 587)

Pages:

27-32

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.587.27

Citation:

Cite this paper

Online since:

November 2013

Authors:

Cristian Parisi, Francesca Gervaso, Francesca Scalera, Sanosh Kunjalukkal Padmanabhan, Concetta Nobile, P. Davide Cozzoli, Lucy Di Silvio, Alessandro Sannino

Keywords:

Bone Scaffold, Bone Substitute, Bone Tissue Engineering, Hydroxyapatite (HA), Nanohydroxyapatite, Nanoparticle, Precipitation Method, Synthesis

Export:

RIS, BibTeX

Price:

Permissions:

Request Permissions

References

[1] O. Faour, R. Dimitriou ,C.A. Cousins ,P.V. Giannoudis, The use of bone graft substitutes in large cancellous voids: any specific needs?, Injury 42 (2011) 87–90.

DOI: 10.1016/j.injury.2011.06.020

Google Scholar

[2] E. M. Younger, M.W. Chapman, Morbidity at bone graft donor sites, J. of Orthopedic Trauma, 3 (1989) 192-195.

DOI: 10.1097/00005131-198909000-00002

Google Scholar

[3] J. R. Porter, T. . T Ruckh, K. C. Popat, Bone tissue engineering: a review in bone biomimetics and drug delivery strategies, Biotechnol. Prog. 25 (2009) 1539-1560.

DOI: 10.1002/btpr.246

Google Scholar

[4] A. J. Salgado, O. P. Coutinho, R. L. Reis, Bone tissue engineering: state of the art and future trends, Macromol. Biosci. 4 (2004) 743-765.

DOI: 10.1002/mabi.200400026

Google Scholar

[5] J. D. Kretlow, A. G. Mikos, Review: mineralization of synthetic polymer scaffolds for bone tissue engineering, Tissue Engineering 13 (2007) 927-938.

DOI: 10.1089/ten.2006.0394

Google Scholar

[6] R.E. Neuendorf, E. Saiz, A.P. Tomsia, R.O. Ritchie, Adhesion between biodegradable polymers and hydroxyapatite: Relevance to synthetic bone-like materials and tissue engineering scaffolds, Acta Biomaterialia 4 (2008) 1288-1296.

DOI: 10.1016/j.actbio.2008.04.006

Google Scholar

[7] J. R. Woodard et al., The mechanical properties and osteoconductivity of hydroxyapatite bone scaffolds with multi-scale porosity, Biomaterials 28 (2007) 45-54.

DOI: 10.1016/j.biomaterials.2006.08.021

Google Scholar

[8] F. Gervaso, F. Scalera, S. K. Padmanabhan, A. Sannino, A. Licciulli, High-performance hydroxyapatite scaffolds for bone tissue engineering applications, Int. J. Appl. Ceram. Technol., 9 (2012) 507–516.

DOI: 10.1111/j.1744-7402.2011.02662.x

Google Scholar

[9] F. Scalera, F. Gervaso, S. K. Padmanabhan, A. Sannino, A. Licciulli, Influence of the calcination temperature on morphological and mechanical properties of highly porous hydroxyapatite scaffolds, Ceramics International 39 (2013) 4839–4846.

DOI: 10.1016/j.ceramint.2012.11.076

Google Scholar

[10] V. V. Smirnov, S. M. Barinov, A. S. Fomin, L. I. Shvorneva, N. S. Sergeeva, Low-temperature calcium carbonate ceramic, Inorganic Materials 1 (2010) 143-148.

DOI: 10.1134/s2075113310020127

Google Scholar