Fast Loading, Slow Release – A New Strategy for Incorporating Antibiotics to Hydroxyapatite

Johan Forsgren; Ulrika Brohede; Albert Mihranyan; Hakan Engqvist; Maria Strømme

doi:10.4028/www.scientific.net/KEM.396-398.523

Paper Titles

Adsorption and Sustained Release of Insulin from Zinc Hydroxyapatite Microparticle with Poly (Lactic Acid) Coating
p.507

Application of New Statistical Approach to Study Drug Release from OCP Coating on Titanium Sheets
p.511

Elaboration of a Well-Ordered Porous Bioceramic via a Heterocoagulation Colloidal Process
p.515

Fabrication of Encapsulated Silicagel Microsphere with Hydroxyapatite for Sustained-Release
p.519

Fast Loading, Slow Release – A New Strategy for Incorporating Antibiotics to Hydroxyapatite
p.523

Gentamicin Sulphate Release from Bioactive Ceramic Calcium Silicates
p.527

In Vitro Evaluation of the Antimicrobial Action of Chlorhexidine Associated to Hydroxyapatite
p.531

Interest of High Shear Wet Granulation to Produce Drug Loaded Porous Calcium Phosphate Pellets for Bone Filling
p.535

Internal Distribution of Several Inorganic Microparticles in Mice
p.539

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Fast Loading, Slow Release – A New Strategy for Incorporating Antibiotics to Hydroxyapatite

Abstract:

The aim of this study was to investigate if it is possible to fast load hydroxyapatite with antibiotics and still obtain a slow but therapeutic release of drugs during several hours. Physical vapour deposition was used to coat commercially pure titanium with a layer of anatase TiO2. On top of this, a layer of hydroxyapatite was deposited using biomimetic precipitation. This hydroxyapatite coating was then soaked in solutions containing antibiotics for various amounts of times. The release rate of the antibiotics was measured in PBS during 22 hours. The released amount was compared with the results from an antimicrobial susceptibility test and proved to be sufficient to kill several ml of bacterial broth during the time of the release measurements. It was shown that the soaking time does not affect the release rate and the results suggest that it is possible to develop implants with the option to add antibiotics to their surface at the site of surgery by a simple soaking method.