Effect of ADM on Proliferation and Apoptosis of Human Gastric Cancer Cell SGC-7901

Shu Li Shao; Wei Wei Chen; Wei Wei Zhang; Wei Zhao; Feng Ying Li

doi:10.4028/www.scientific.net/AMR.535-537.2434

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 535-537Effect of ADM on Proliferation and Apoptosis of...

Effect of ADM on Proliferation and Apoptosis of Human Gastric Cancer Cell SGC-7901

Abstract:

To observe the effect of ADM on cells apoptosis of SGC-7901 cells. The SGC-7901 cells were treated by ADM. And the inhibitory ratio of cells was measured by trypan blue stain assay, the IC50 value was calculated. Cells apoptosis were detected by DNA agarose gel electrophoresis.The cell cycles were analyzed by flow cytometry system after treatment with ADM. Morphologic changes were observed using phase-contrast microscopy . The SGC-7901 cells proliferation were remarkably inhibited by ADM. The IC50 values were 5.7 μg / mL. The typical DNA ladder on agarose gel electrophoresis for analysis of cellular apoptosis were significantly appeared. ADM could restrain the SGC-7901 cells proliferation, and to cause the morphologic changes of apoptosis. Apoptosis peaks appeared with flow cytometry analysis.

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Periodical:

Advanced Materials Research (Volumes 535-537)

Pages:

2434-2437

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.535-537.2434

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Online since:

June 2012

Authors:

Shu Li Shao, Wei Wei Chen, Wei Wei Zhang, Wei Zhao, Feng Ying Li

Keywords:

ADM, Apoptosis, Gastric Cancer

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