Preparation of PLLA/HAP/β-TCP Composite Scaffold for Bone Tissue Engineering

Xue Jun Wang; Tao Lou; Jing Yang; Zhen Yang; Kun Peng He

doi:10.4028/www.scientific.net/AMM.513-517.143

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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vols. 513-517Preparation of PLLA/HAP/β-TCP Composite Scaffold...

Preparation of PLLA/HAP/β-TCP Composite Scaffold for Bone Tissue Engineering

Abstract:

In this study, a nanofibrous poly (L-lactic acid) (PLLA) scaffold reinforced by Hydroxyapatite (HAP) and β-tricalcium phosphate (β-TCP) was fabricated using the thermally induced phase separation method. The composite scaffold morphology showed a nanofibrous PLLA matrix and evenly distributed β-TCP/HAP particles. The composite scaffold had interconnective micropores and the pore size ranged 2-10 μm. Introducing β-TCP/HAP particles into PLLA matrix significantly improved the mechanical properties of the composite scaffold. In summary, the new composite scaffolds show a great deal promise for use in bone tissue engineering.

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Periodical:

Applied Mechanics and Materials (Volumes 513-517)

Pages:

143-146

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.513-517.143

Citation:

Cite this paper

Online since:

February 2014

Authors:

Xue Jun Wang*, Tao Lou, Jing Yang, Zhen Yang, Kun Peng He

Keywords:

HAp, PLLA, Scaffold, Tissue Engineering, β-TCP

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* - Corresponding Author

References

[1] Hollister SJ. Porous scaffold design for tissue engineering. Nat mater. 2005; 4: 518-524.

Google Scholar

[2] Kim HN, Jiao A, Hwang NS, Kim MS, Kang do H, Kim DH, et al. Nanotopography-guided tissue engineering and regenerative medicine. Advanced drug delivery reviews. 2013; 65: 536-558.

DOI: 10.1016/j.addr.2012.07.014

Google Scholar

[3] Wang XJ, Song GJ, Lou T, Peng WJ. Fabrication of nano-fibrous PLLA scaffold reinforced with chitosan fibers. Journal of biomaterials science-Polymer Edition. 2009; 20: 1995-(2002).

DOI: 10.1163/156856208x396083

Google Scholar

[4] Jin HH, Kim DH, Kim TW, Shin KK, Jung JS, Park HC, et al. In vivo evaluation of porous hydroxyapatite/chitosan-alginate composite scaffolds for bone tissue engineering. International journal of biological macromolecules. 2012; 51: 1079-1085.

DOI: 10.1016/j.ijbiomac.2012.08.027

Google Scholar

[5] Wang XJ, Song GJ, Lou T. Fabrication and characterization of nano composite scaffold of poly(l-lactic acid)/hydroxyapatite. Journal of materials science-Materials in medicine. 2010; 21: 183-188.

DOI: 10.1007/s10856-009-3855-5

Google Scholar

[6] Dorozhkin SV. Biphasic, triphasic and multiphasic calcium orthophosphates. Acta biomaterialia. 2012; 8: 963-977.

DOI: 10.1016/j.actbio.2011.09.003

Google Scholar

[7] Wang XJ, Song GJ, Lou T. Fabrication and characterization of nano-composite scaffold of PLLA/silane modified hydroxyapatite. Medical engineering & physics. 2010; 32: 391-397.

DOI: 10.1016/j.medengphy.2010.02.002

Google Scholar

[8] Cao H, Kuboyama N. A biodegradable porous composite scaffold of PGA/beta-TCP for bone tissue engineering. Bone. 2010; 46: 386-395.

DOI: 10.1016/j.bone.2009.09.031

Google Scholar

[9] Lou T, Wang X, Song G. Fabrication of nano-fibrous poly(l-lactic acid) scaffold reinforced by surface modified chitosan micro-fiber. International journal of biological macromolecules. 2013; 61C: 353-358.

DOI: 10.1016/j.ijbiomac.2013.07.025

Google Scholar

[10] Place ES, George JH, Williams CK, Stevens MM. Synthetic polymer scaffolds for tissue engineering. Chemical society reviews. 2009; 38: 1139-1151.

DOI: 10.1039/b811392k

Google Scholar

[11] Liu H, Peng H, Wu Y, Zhang C, Cai Y, Xu G, et al. The promotion of bone regeneration by nanofibrous hydroxyapatite/chitosan scaffolds by effects on integrin-BMP/Smad signaling pathway in BMSCs. Biomaterials. 2013; 34: 4404-4417.

DOI: 10.1016/j.biomaterials.2013.02.048

Google Scholar

[12] Ebrahimian-Hosseinabadi M, Ashrafizadeh F, Etemadifar M, Venkatraman SS. Preparation and mechanical behavior of PLGA/nano-BCP composite scaffolds during in-vitro degradation for bone tissue engineering. Polymer Degradation and Stability. 2011; 96: 1940-(1946).

DOI: 10.1016/j.polymdegradstab.2011.05.016

Google Scholar

[13] Bose S, Roy M, Bandyopadhyay A. Recent advances in bone tissue engineering scaffolds. Trends in biotechnology. 2012; 30: 546-554.

DOI: 10.1016/j.tibtech.2012.07.005

Google Scholar