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Up-Converting Nanoparticles: Promising Markers for Biomedical Applications

Up-Converting Nanoparticles: Promising Markers for Biomedical Applications

Livia Petrescu, Speranta Avram, Maria Mernea, Dan Florin Mihailescu
Copyright: © 2018 |Pages: 34
ISBN13: 9781522531586|ISBN10: 1522531580|EISBN13: 9781522531593
DOI: 10.4018/978-1-5225-3158-6.ch011
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MLA

Petrescu, Livia, et al. "Up-Converting Nanoparticles: Promising Markers for Biomedical Applications." Biomedical Engineering: Concepts, Methodologies, Tools, and Applications, edited by Information Resources Management Association, IGI Global, 2018, pp. 278-311. https://doi.org/10.4018/978-1-5225-3158-6.ch011

APA

Petrescu, L., Avram, S., Mernea, M., & Mihailescu, D. F. (2018). Up-Converting Nanoparticles: Promising Markers for Biomedical Applications. In I. Management Association (Ed.), Biomedical Engineering: Concepts, Methodologies, Tools, and Applications (pp. 278-311). IGI Global. https://doi.org/10.4018/978-1-5225-3158-6.ch011

Chicago

Petrescu, Livia, et al. "Up-Converting Nanoparticles: Promising Markers for Biomedical Applications." In Biomedical Engineering: Concepts, Methodologies, Tools, and Applications, edited by Information Resources Management Association, 278-311. Hershey, PA: IGI Global, 2018. https://doi.org/10.4018/978-1-5225-3158-6.ch011

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Abstract

Up-converting nanoparticles are dielectric crystalline particles doped with rare-earth ions such as Yb3+, Er3+, Tm3+, Ho3+, Nd3+, etc. When excited in infrared, they emit visible radiation. Used as markers, they present significant advantages in comparison to traditional fluorophores: sharp emission lines, superior photostability, resistence to photobleaching, no blinking and lack of toxicity. Infrared radiation is less harmful to cells avoiding tissue degradation, minimizes auto-fluorescence from endogenous biocomponents offering a good signal-to-background ratio and penetrates tissues deeply. In spite of the great advantages of using up-converting nanoparticles for biomedical applications, there are still some limitations. These refer to identification of optimal size suited for specific samples, prevention of aggregation, water stability/dispersibility, optical efficiency and biocompatibility. This chapter reviews principal characteristics of up-converting nanoparticles and issues related to their use in biomedical applications.

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