Enhanced silver diamine fluoride therapy using the PILP method —A nanoindentation study

Hamid NURROHMAN; Stefan HABELITZ; Kuniko SAEKI; Alireza SADR; Laurie B. GOWER; Vanessa PAZDERNIK; Junji TAGAMI; Sally J. MARSHALL; Grayson W. MARSHALL

doi:10.4012/dmj.2019-273

Original Paper

Enhanced silver diamine fluoride therapy using the PILP method —A nanoindentation study

Hamid NURROHMAN, Stefan HABELITZ, Kuniko SAEKI, Alireza SADR, Laurie B. GOWER, Vanessa PAZDERNIK, Junji TAGAMI, Sally J. MARSHALL, Grayson W. MARSHALL

Author information

Hamid NURROHMAN
Missouri School of Dentistry and Oral Health, A.T. Still University
Department of Preventive and Restorative Dental Sciences, University of California San Francisco
Stefan HABELITZ
Department of Preventive and Restorative Dental Sciences, University of California San Francisco
Kuniko SAEKI
Department of Preventive and Restorative Dental Sciences, University of California San Francisco
Alireza SADR
Biomimetics Biomaterials Biophotonics & Technology Laboratory, Department of Restorative Dentistry, University of Washington School of Dentistry
Laurie B. GOWER
Materials Science and Engineering Department, University of Florida
Vanessa PAZDERNIK
Department of Research Support, A. T. Still University
Junji TAGAMI
Department of Cariology and Operative Dentistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
Sally J. MARSHALL
Department of Preventive and Restorative Dental Sciences, University of California San Francisco
Grayson W. MARSHALL
Department of Preventive and Restorative Dental Sciences, University of California San Francisco

Keywords: Silver diamine fluoride, Artificial caries dentin lesion, Polymer-induced liquid-precursor, Caries arrest, Nanomechanical recovery

JOURNAL FREE ACCESS

2020 Volume 39 Issue 6 Pages 1009-1015

DOI https://doi.org/10.4012/dmj.2019-273

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Abstract

The aim of this study was to evaluate the feasibility of applying the polymer-induced liquid-precursor (PILP) method to enhance silver diamine fluoride (SDF) therapy. One hundred forty micrometer deep artificial caries lesions were treated with (A) 38% SDF solution and (B) 38% SDF containing poly-L-aspartic acid (pASP). Changes in the nanomechanical profile across the lesion were evaluated. Hydrated artificial lesions had a low reduced elastic modulus (0.3 GPa) and nanohardness (0.02 GPa) region extending about 100 μm into the lesion, with a gradual linear increase to about 168 μm where the values plateaued to around 18 GPa/1.0 GPa. Topical application of SDF resulted in significantly recovered properties (p<0.001). SDF containing pASP resulted in greater nanomechanical properties compared to SDF alone, showing similar sloped regions up to 96 μm, then SDF alone dropped while SDF containing pASP continued at a modest slope until reaching normal at 144 μm. This nanoindentation study shows enhanced SDF therapy using the PILP method.

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