The purpose of this study was to investigate the effect of substituting triethyleneglycol dimethacrylate (TEGDMA) with 2,2,2-trifluoroethyl methacrylate (TFEMA) on water sorption, water solubility, degree of conversion, polymerization shrinkage, fluoride release and flexural strength of bisphenol-A-glycerolate dimethacrylate (Bis-GMA)/TEGDMA/urethane dimethacrylate (UDMA) dental composites. Flexural strength, water sorption and water solubility were measured according to ISO 4049 standard. Degree of conversion was determined by FTIR technique. Fluoride release rate in deionized water at 37°C was determined by using photometric method. One-way ANOVA and Tukey’s HSD tests were used for statistical significance analysis (p<0.05). The results demonstrated that TFEMA decreased water solubility and volumetric shrinkage significantly but neither reduced water sorption, enhanced flexural strength nor improved degree of conversion. Partial substitution of TEGDMA with TFEMA in Bis-GMA/TEGDMA/UDMA dental composite had positive effect on its water solubility and volumetric shrinkage quality.