Antibacterial activity, cytotoxicity and mechanical behavior of nano-enhanced denture base resin with different kinds of inorganic antibacterial agents

Rongrong CHEN; Zhihui HAN; Zhuoli HUANG; Junu KARKI; Chenxin WANG; Bangshang ZHU; Xiuyin ZHANG

doi:10.4012/dmj.2016-301

Original Paper

Antibacterial activity, cytotoxicity and mechanical behavior of nano-enhanced denture base resin with different kinds of inorganic antibacterial agents

Rongrong CHEN, Zhihui HAN, Zhuoli HUANG, Junu KARKI, Chenxin WANG, Bangshang ZHU, Xiuyin ZHANG

Author information

Rongrong CHEN
Department of Prosthodontics, 9th People’s Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai Key Laboratory of Stomatology
Zhihui HAN
Department of Prosthodontics, 9th People’s Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai Key Laboratory of Stomatology
Zhuoli HUANG
Department of Prosthodontics, 9th People’s Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai Key Laboratory of Stomatology
Junu KARKI
Department of Prosthodontics, 9th People’s Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai Key Laboratory of Stomatology
Chenxin WANG
Department of Prosthodontics, 9th People’s Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai Key Laboratory of Stomatology
Bangshang ZHU
Instrumental Analysis Center, Shanghai Jiao Tong University
Xiuyin ZHANG
Department of Prosthodontics, 9th People’s Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai Key Laboratory of Stomatology

Keywords: ZrO₂-ABWs/PMMA, Antibacterial materials, Antibacterial activity, Cytotoxicity, Mechanical property

JOURNAL FREE ACCESS

2017 Volume 36 Issue 6 Pages 693-699

DOI https://doi.org/10.4012/dmj.2016-301

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Details

Abstract

Silanized aluminum borate whiskers (ABWs) of 4 wt%, silanized zirconium dioxide nanoparticles (nano-ZrO₂) of 2 wt% were mixed with polymethyl methacrylate (PMMA) powder to get ZrO₂-ABWs/PMMA composites. Titanium dioxide (TiO₂), silver-supported titanium dioxide (Ag/TiO₂), silver-supported zirconium phosphate (Novaron) and tetrapod-like zinc oxide whiskers (T-ZnOw) antibacterial agents of 3 wt% were mixed with ZrO₂-ABWs/PMMA composites respectively to fabricate standard specimens. Plaque biofilms on the specimens surface were investigated for colony-forming units (CFUs). In addition, cytotoxicity and mechanical behavior were evaluated. Results showed that the CFUs values of S. mutans and C. albican biofilms on the four antibacterial composites surface were all reduced (p<0.05) compared to the blank and control groups. The antibacterial composites did not have an adverse effect on fibroblast growth in this study (p>0.05) except TiO₂ and Ag/TiO₂ groups of undiluted extracts. The flexural strength and surface hardness of Novaron and T-ZnOw groups were increased (p<0.05) compared to the control group.

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