Sweeteners, an important food additive, are indispensable in the modern food production industries and can be applied to a variety of foods. Despite the continuous development of safety standards and regulatory systems for food additives in China, some producers still blindly pursue profits due to the rapid development of the sweetener industry. Therefore, there are still a lot of problems about use and production of sweeteners, such as over-and out-of-range use of sweeteners, abuse of complex sweeteners, several sweeteners using together, nonconforming labeling, unacceptable qualities of sweeteners, and masking of food quality defects or doping with sweeteners for adulteration and forgery. Food producers should reasonably regulate the production and use of sweeteners to avoid the harm to consumers' health. Consumers should also rationally perceive sweeteners, purchase products from regular channels, and have rational diet.