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    Infect Chemother. 2008 Nov-Dec;40(6):316-322. Korean.
    Published online Dec 31, 2008.
    https://doi.org/10.3947/ic.2008.40.6.316
    Copyright © 2008 The Korean Society of Infectious Diseases and The Korean Society for Chemotherapy
    Original Article

    Characteristics of Infective Endocarditis in 4 University Hospitals where Staphylococcus aureus is the Most Common Causative Organism

    Sung Woo Seo, M.D.,1 Tae Hyong Kim, M.D.,1 Min Su Hyon, M.D.,1 Eun Ju Choo, M.D., Min Hyok Jeon, M.D., Chul Moon, M.D.,2 Dan Song, M.D.,2 Jong Hwa Kim, M.D.,1 Yong Gwan Lee, M.D.,1 Jong Hyo Choi, M.D.,1 Woong Jeon, M.D.,1 Young Sin Jo, M.D.,1 and Moon Han Choi, M.D.1
      • 1Department of Internal Medicine, Soon Chun Hyang University, College of Medicine, Seoul, Korea.
      • 2Department of Surgery, Soon Chun Hyang University, College of Medicine, Seoul, Korea.
    • Correspondence: Tae Hyong Kim, M.D. Division of Infectious Diseases, Department of Internal Medicine, Soon Chun Hyang University Hospital, 22 Daesagwan-gil, Yongsan-gu, Seoul, Korea. Tel: +82-2-709-9029, Fax: +82-2-792-5812, Email: geuncom@hosp.sch.ac.kr
    Received August 21, 2008; Accepted October 08, 2008.

    This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Abstract

    Background

    To evaluate whether Staphylococcus aureus is actually the leading cause of infective endocarditis in Korea, investigation on updated clinical pictures, treatments, and prognosis was performed. This study also aims to describe differences in clinical characteristics of infective endocarditis in patients undergoing maintenance hemodialysis.

    Materials and Methods

    Fifty five patients who were diagnosed with infective endocarditis, using modified Duke criteria, at 4 Soon Chun Hyang University Hospitals (located in Seoul, Bucheon, Cheonan, and Gumi) from January of 2000 to June of 2007 were enrolled. Patients were separated into two groups; those on hemodialysis and those who were not on hemodialysis (control group). Medical records and laboratory results of each patient were reviewed retrospectively.

    Results

    The positive rate of blood culture was 72.7%. Staphylococcus aureus was isolated in 38.2% of the patients, making it the most common causative organism of infective endocarditis. It was also the most common organism in both hemodialysis group and non-hemodialysis group. Six patients (10.9%) died while admitted to the hospital and the in-hospital death rate for hemodialysis group was significantly higher.

    Conclusion

    In most parts of the world, S. aureus is increasingly becoming the principal causative organism of infective endocarditis. To our knowledge, this is the first study that shows S. aureus to be the most common causative organism of infective endocarditis in Korea, and that Korea is not except from this global epidemiology.

    Keywords
    Infective endocarditis; S. aureus; Hemodialysis

    Tables

    Table 1
    Initial Clinical & Laboratory Characteristics of Infective Endocarditis Patients

    Table 2
    Microbiologic Characteristics of Infective Endocarditis

    Table 3
    Presence and Location of Vegetations among Infective Endocarditis Patients

    Table 4
    Causative Organism of Infective Endocarditis

    Table 5
    Causative Organism of Infective Endocarditis

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    MeSH Terms
    Endocarditis
    Hospitals, University
    Humans
    Korea
    Medical Records
    Prognosis
    Renal Dialysis
    Retrospective Studies
    Staphylococcus
    Staphylococcus aureus
    Metrics
    Share
    Tables
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