Elsevier

The Journal of Nutrition

Volume 145, Issue 12, December 2015, Pages 2741-2748
The Journal of Nutrition

Zinc Intake Is Associated with Lower Cadmium Burden in US Adults1, 2, 3

https://doi.org/10.3945/jn.115.223099Get rights and content
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Abstract

Background: Cadmium is a toxic transition metal whose absorption and accumulation might depend on zinc intake.

Objective: We sought to determine whether zinc intake and serum zinc would be inversely associated with cadmium exposure.

Methods: This study used data from NHANES 2003–2012, from which there were 6678 and 6488 participants with urinary and blood cadmium data, respectively, and 1195 participants with serum zinc data. Mean blood and urinary cadmium were reported by quintiles of zinc intake and by the dose and duration of zinc supplement use. The associations between zinc intake from diet and supplements, serum zinc, and blood and urinary cadmium were determined using multiple regression. Analyses were adjusted for age, body mass index, race/ethnicity, gender, income-to-poverty ratio, education, smoking status, and mean intakes of energy, calcium, and iron.

Results: Urinary cadmium concentrations were 0.04 <g/g creatinine lower among participants in the highest compared with lowest quintile of total zinc intake (P-trend = 0.0041). Zinc supplement dose and duration were inversely associated with blood cadmium (P = 0.0372) and serum zinc (P-trend = 0.0017), respectively. In adjusted regression models, a 10% increase in total zinc intake corresponded to a predicted decrease in blood cadmium of 0.42% (95% CI: −0.79%, −0.06%; P = 0.0260) and in urinary cadmium of 0.42% (95% CI: −0.81%, −0.04%; P = 0.0340). A 10% increase in serum zinc was associated with a predicted 1.99% (95% CI: −3.17%, −0.81%; P = 0.0012) decrease in blood cadmium and a predicted 4.09% (95% CI: 2.14%, 6.04%, P = 0.0001) increase in urinary cadmium.

Conclusions: Dietary and serum zinc in US adults are associated with cadmium exposure, presumably by influencing the absorption and accumulation of cadmium. Whether the degree of reduction in cadmium exposure from greater zinc intake and status is causal or relevant from a public health perspective needs further investigation.

Key Words

cadmium
zinc
NHANES
diet
exposure

Cited by (0)

1

The authors reported no funding received for this study.

2

Author disclosures: TM Vance and OK Chun, no conflicts of interest.

3

Supplemental Tables 1–3 are available from the “Online Supporting Material” link in the online posting of the article and from the same link in the online table of contents at http://jn.nutrition.org.