Fibroblast Growth Factor 21 (Fgf21) Gene Expression Is Elevated in the Liver of Mice Fed a High-Carbohydrate Liquid Diet and Attenuated by a Lipid Emulsion but Is Not Upregulated in the Liver of Mice Fed a High-Fat Obesogenic Diet123
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Supported by funds from the Graduate Program in Nutrition, Graduate Program in Food Science, Dorothy Foehr Huck Chair (ACR), and NIH grants CA90214 (ACR) and AT004678 (JDL). Baxter Healthcare Corporation provided the liquid diet (Clinimix E), vitamins, and lipid emulsion (Intralipid) used in studies 1 and 2. A postdoctoral research award from Baxter to the Department of Nutritional Sciences partially supported KI.
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Author disclosures: L Hao, K-H Huang, K Ito, S Sae-tan, JD Lambert, and AC Ross, no conflicts of interest.
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Supplemental Tables 1 and 2 are available from the “Online Supporting Material” link in the online posting of the article and from the same link in the online table of contents at http://jn.nutrition.org.
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Present address: Laboratory for Lipid Medicine and Technology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129.
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Present address: Department of Medicine, Jikei University, Tokyo, Japan.
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Present address: Department of Food Science and Technology, Faculty of Agro-Industry, Kasetsart University, Bangkok, Thailand.
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These authors contributed equally to this work.