Elsevier

Advances in Nutrition

Volume 2, Issue 4, July 2011, Pages 325-331
Advances in Nutrition

Trafficking of Intracellular Folates

https://doi.org/10.3945/an.111.000596Get rights and content
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ABSTRACT

The role of metabolic compartmentation in spatially organizing metabolic enzymes into pathways, regulating flux through metabolic pathways, and controlling the partitioning of metabolic intermediates among pathways is appreciated, but our understanding of the mechanisms that establish metabolic architecture and mediate communication and regulation among interconnected metabolic pathways and networks is still incomplete. This review discusses recent advancements in our understanding of metabolic compartmentation within the pathways that constitute the folate-mediated one-carbon metabolic network and emerging evidence for a need to regulate the trafficking of folates among compartmentalized metabolic pathways.

Abbreviations used

AICAR Tfase
aminoimidazolecarboxamide ribonucleotide transformylase
DHF
dihydrofolate
DHFR
dihydrofolate reductase
FDH
formyltetrahydrofolate dehydrogenase
GAR Tfase
glycinamide ribonucleotide transformylase
MTHFD1
methylenetetrahydrofolate dehydrogenase
MTHFR
methylenetetrahydrofolate reductase MTHFS, methenyltetrahydrofolate synthetase
SHMT
serine hydroxymethyltransferase
THF
tetrahydrofolate
TYMS
thymidylate synthase

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Supported by Public Health Service grant DK58144 to P.J.S.

Author disclosures: P. J. Stover and M. S. Field, no conflicts of interest.