Orphan nuclear receptor Nurr1 as a potential novel marker for progression in human pancreatic ductal adenocarcinoma

  • Authors:
    • Li Ji
    • Chen Gong
    • Liangyu Ge
    • Linping Song
    • Fenfen Chen
    • Chunjing Jin
    • Hongyan Zhu
    • Guoxiong Zhou
  • View Affiliations

  • Published online on: December 13, 2016     https://doi.org/10.3892/etm.2016.3968
  • Pages: 551-559
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Abstract

Nuclear receptor related‑1 protein (Nurr1) is a novel orphan member of the nuclear receptor superfamily (the NR4A family) involved in tumorigenesis. The aim of the present study was to investigate the expression and possible function of Nurr1 in pancreatic ductal adenocarcinoma (PDAC). The expression pattern of Nurr1 protein was determined using immunohistochemical staining in 138 patients with PDAC. Elevated Nurr1 expression was more commonly observed in PDAC tissues and cell lines compared with healthy controls. Elevated expression was significantly associated with histological differentiation (P=0.041), lymph node metastasis (P=0.021), TNM classification of malignant tumors stage (P=0.031) and poor survival (P=0.001). Further experiments demonstrated that suppression of endogenous Nurr1 expression attenuated cell proliferation, migration and invasion, and induced apoptosis of PDAC cells. In conclusion, these results suggest that Nurr1 has an important role in the progression of PDAC and may be used as a novel marker for therapeutic targets.

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February-2017
Volume 13 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Ji L, Gong C, Ge L, Song L, Chen F, Jin C, Zhu H and Zhou G: Orphan nuclear receptor Nurr1 as a potential novel marker for progression in human pancreatic ductal adenocarcinoma. Exp Ther Med 13: 551-559, 2017
APA
Ji, L., Gong, C., Ge, L., Song, L., Chen, F., Jin, C. ... Zhou, G. (2017). Orphan nuclear receptor Nurr1 as a potential novel marker for progression in human pancreatic ductal adenocarcinoma. Experimental and Therapeutic Medicine, 13, 551-559. https://doi.org/10.3892/etm.2016.3968
MLA
Ji, L., Gong, C., Ge, L., Song, L., Chen, F., Jin, C., Zhu, H., Zhou, G."Orphan nuclear receptor Nurr1 as a potential novel marker for progression in human pancreatic ductal adenocarcinoma". Experimental and Therapeutic Medicine 13.2 (2017): 551-559.
Chicago
Ji, L., Gong, C., Ge, L., Song, L., Chen, F., Jin, C., Zhu, H., Zhou, G."Orphan nuclear receptor Nurr1 as a potential novel marker for progression in human pancreatic ductal adenocarcinoma". Experimental and Therapeutic Medicine 13, no. 2 (2017): 551-559. https://doi.org/10.3892/etm.2016.3968