Social Relevance and Post-stroke Epilepsy Prevention

Christian  Naydenov; Boryana Parashkevova-Simeonova; Velina Mancheva

doi:10.3889/oamjms.2022.10680

Authors

Christian Naydenov Department of Neurology and Psychiatry, Faculty of Medicine, Trakia University, Stara Zagora, Bulgaria
Boryana Parashkevova-Simeonova Department of Public Health, Faculty of Medicine, Trakia University, Stara Zagora, Bulgaria https://orcid.org/0000-0003-0249-5986
Velina Mancheva Department of Neurology and Psychiatry, Faculty of Medicine, Trakia University, Stara Zagora, Bulgaria

DOI:

https://doi.org/10.3889/oamjms.2022.10680

Keywords:

Stroke, Epilepsy, Risk factors, Early prophylaxis

Abstract

Abstract: Stroke is an important cerebrovascular disease resulting in long-term disability and death. A rare consequence of stroke is structural epilepsy. Here we discuss the importance of post-stroke epilepsy prevention. We look into the occurrence of stroke and epilepsy in the general population, the risk factors and severity of those conditions and the significance of early seizure prevention after the stroke. We analyze published research papers and reviews dealing with this problem. In brief, there is a diagnostic problem leading to ineffective treatment. On one hand preventing seizures in patients with no history of epilepsy, treating them with medications with known side effects. On the other hand by not treating them, risk seizures and future repercussions for their health and wellbeing. Here we propose ways to select patients for treatment and refine the diagnostic considerations for early start of anti-seizure therapy.

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References

Guekht A, Hauser W, Milchakova L, Churillin Y, Shpak A, Gusev E. The epidemiology of epilepsy in the Russian Federation. Epilepsy Res. 2010;92(2-3):209-18. https://doi.org/10.1016/j.eplepsyres.2010.09.011 PMid:21035312 DOI: https://doi.org/10.1016/j.eplepsyres.2010.09.011

Feigin VL, Forouzanfar MH, Krishnamurthi R, Mensah GA, Connor M, Bennett DA, et al. Global and regional burden of stroke during 1990-2010: Findings from the Global burden of disease study 2010. Lancet. 2014;383(9913):245-54. https://doi.org/10.1016/s0140-6736(13)61953-4 PMid:24449944 DOI: https://doi.org/10.1016/S0140-6736(13)61953-4

Guekht A, Bornstein N. Seizures after stroke. Handbook of Clinical Neurology. Vol. 108. Ch. 34. Amsterdam: Elsevier; 2012. p. 569-83. https://doi.org/10.1016/B978-0-444-52899-5.00016-2 DOI: https://doi.org/10.1016/B978-0-444-52899-5.00016-2

Donnan GA, Fisher M, Macleod M, Davis SM. Stroke. Lancet. 2008;371(9624):1612-23. https://doi.org/10.1016/S0140-6736(08)60694-7 PMid:18468545 DOI: https://doi.org/10.1016/S0140-6736(08)60694-7

Ellekjær H, Holmen J, Indredavik B, Terent A. Epidemiology of stroke in Innherred, Norway, 1994 to 1996: Incidence and 30-day case-fatality rate. Stroke 1997;28(11):2180-4. https://doi.org/10.1161/01.str.28.11.2180 PMid:9368561 DOI: https://doi.org/10.1161/01.STR.28.11.2180

Senelick RC, Rossi PW, Dougherty K. Living with Stroke: A Guide for Families; Contemporary Books. Chicago: Publisher Healthsouth Press; ISBN-10: 1891525166; ISBN-13: 978-1891525162; 1994.

National Institute of Neurological Disorders and Stroke. Stroke: Hope Through Rsearch; National Institutes of Health. Bethesda: National Institute of Neurological Disorders and Stroke; 1999.

Sander JW. The epidemiology of epilepsy revisited. Curr Opin Neurol. 2003;16(2):165-70. https://doi.org/10,1097/00019052-200304000-00008 PMid:12644744 DOI: https://doi.org/10.1097/00019052-200304000-00008

Thurman DJ, Beghi E, Begley CE, Berg AT, Buchhalter JR, Ding D, et al. Standards for epidemiologic studies and surveillance of epilepsy. Epilepsia. 2011;52 Suppl 7:2-26. https://doi.ORG/10,1111/j.1528-1167,2011.03121.x PMid:21899536 DOI: https://doi.org/10.1111/j.1528-1167.2011.03121.x

Holmes GL, Browne TR. Handbook of Epilepsy. 4th. Philadelphia, PA: Lippincott Williams and Wilkins; 2008.

Newton CR, Garcia HH. Epilepsy in poor regions of the world. Lancet. 2012;380(9848):1193-201. https://doi.org/10,1016/S0140-6736(12)61381-6 PMid:23021288 DOI: https://doi.org/10.1016/S0140-6736(12)61381-6

Neligan A, Hauser WA, Sander JW. The epidemiology of the epilepsies. Handb Clin Neurol. 2012;107:113-33. https://doi.org/10,1016/B978-0-444-52898-8,00006-9 PMid:22938966

Marsh L, Rao V. Psychiatric complications in patients with epilepsy: A review. Epilepsy Res. 2002;49(1):11-33. https://doi.org/10.1016/s0920-1211(02)00008-6 PMid:11948004 DOI: https://doi.org/10.1016/S0920-1211(02)00008-6

Kanner AM. Depression in epilepsy: A frequently neglected multifaceted disorder. Epilepsy Behav. 2005;4 Suppl 4:11-9. https://doi.org/10.1016/j.yebeh.2003.10.004 PMid:14654423 DOI: https://doi.org/10.1016/j.yebeh.2003.10.004

Naydenov K, Petkov Y, Manchev I, Chengeliyska V, Komsiyska D. Comorbidity of epilepsy and mental disorders. Trakia J Sci. 2019;3:243-6. https://doi.org/10.15547/tjs.2019.03.010 DOI: https://doi.org/10.15547/tjs.2019.03.010

Flor-Henry P. Psychosis and temporal lobe epilepsy-A controlled investigation. Epilepsia. 1969;10(3):363-95. https://doi.org/10.1111/j.1528-1157.1969.tb03853.x PMid:5256909 DOI: https://doi.org/10.1111/j.1528-1157.1969.tb03853.x

Sherwin I. Psychosis associated with epilepsy: Significance of the laterality of the epileptogenic lesion. J Neurol Neurosurg Psychiatry. 1981;44(1):83-5. https://doi.org/10.1136/jnnp.44.1.83 PMid:7205310 DOI: https://doi.org/10.1136/jnnp.44.1.83

Logsdail SJ, Toone BK. Postictal psychoses: A clinical and phenomenological description. Br J Psych. 1988;152:246-52. https://doi.org/10.1192/bjp.152.2.246 PMid:3167343 DOI: https://doi.org/10.1192/bjp.152.2.246

Onuma T, Adachi N, Ishida S, Katou M, Uesugi S. Prevalence and annual incidence of psychosis in patients with epilepsy. Psychiatry Clin Neurosci. 1995;49(3):267-8. https://doi.org/10.1111/j.1440-1819.1995.tb02201.x PMid:8612169 DOI: https://doi.org/10.1111/j.1440-1819.1995.tb02201.x

Sachdev P. Schizophrenia-like psychosis and epilepsy: The status of the association. Am J Psychiatry. 1998;155(3):325-36. https://doi.org/10.1176/ajp.155.3.325 PMid:9501741 DOI: https://doi.org/10.1176/ajp.155.3.325

Kanemoto K, Tsuji T, Kawasaki J. Reexamination of interictal psychoses based on DSM IV psychosis classification and international epilepsy classification. Epilepsia. 2001;42(1):98-103. https://doi.org/10.1046/j.1528-1157.2001.09000.x PMid:11207792 DOI: https://doi.org/10.1046/j.1528-1157.2001.09000.x

Bladin CF, Alexandrov AV, Bellavance A, Bornstein N, Chambers B, Coté R, et al. Seizures after stroke: A prospective multicenter study. Arch Neurol. 2000;57(11):1617-22. https://doi.org/10.1001/archneur.57.11.1617 PMid:11074794 DOI: https://doi.org/10.1001/archneur.57.11.1617

Graham NS, Crichton S, Koutroumanidis M, Wolfe CD, Rudd AG. Incidence and associations of post-stroke epilepsy the prospective South London stroke register. Stroke. 2013;44(3):605-11. https://doi.org/10.1161/STROKEAHA.111.000220 PMid:23370202 DOI: https://doi.org/10.1161/STROKEAHA.111.000220

Chang CS, Liao CH, Lin CC, Lane HY, Sung FC, Kao CH. Patients with epilepsy are at an increased risk of subsequent stroke: A population-based cohort study. Seizure. 2014;23(5):377-81. https://doi.org/10.1016/j.seizure.2014.02.007 PMid:24630806 DOI: https://doi.org/10.1016/j.seizure.2014.02.007

Arntz R, Rutten-Jacobs L, Maaijwee N, Schoonderwaldt H, Dorresteijn L, van Dijk E, et al. Post-stroke epilepsy in young adults: A long-term follow-up study. PLoS One. 2013;8(2):e55498. https://doi.org/10.1371/journal.pone.0055498 PMid:23390537 DOI: https://doi.org/10.1371/journal.pone.0055498

Burn J, Dennis M, Bamford J, Sandercock P, Wade D, Warlow C. Epileptic seizures after a first stroke: The Oxfordshire community stroke project. BMJ. 1997;315(7122):1582-87. https://doi.org/10.1136/bmj.315.7122.1582 PMid:9437276 DOI: https://doi.org/10.1136/bmj.315.7122.1582

Lamy C, Domigo V, Semah F, Arquizan C, Trystram D, Coste J, et al. Early and late seizures after cryptogenic ischemic stroke in young adults. Neurology. 2003;60(3):400-4. https://doi.org/10.1212/wnl.60.3.400 PMid:12578918 DOI: https://doi.org/10.1212/WNL.60.3.400

Roivainen R, Haapaniemi E, Putaala J, Kaste M, Tatlisumak T. Young adult ischaemic stroke related acute symptomatic and late seizures: Risk factors. Eur J Neurol. 2013;20(9):1247-55. https://doi.org/10.1111/ene.12157 PMid:23581284 DOI: https://doi.org/10.1111/ene.12157

Hsu CJ, Weng WC, Peng SS, Lee WT. Early-onset seizures are correlated with late-onset seizures in children with arterial ischemic stroke. Stroke. 2014;45(4):1161-63. https://doi.org/10.1161/STROKEAHA.113.004015 PMid:24595587 DOI: https://doi.org/10.1161/STROKEAHA.113.004015

Heuts-van Raak L, Lodder J, Kessels F. Late seizures following a first symptomatic brain infarct are related to large infarcts involving the posterior area around the lateral sulcus. Seizure. 1996;5(3):185-94. https://doi.org/10.1016/s1059-1311(96)80034-3 PMid:8902919 DOI: https://doi.org/10.1016/S1059-1311(96)80034-3

Leone MA, Tonini MC, Bogliun G, Gionco M, Tassinari T, Bottacchi E, et al. Risk factors for a first epileptic seizure after stroke: A case control study. J Neurol Sci. 2009;277:138e142. https://doi.org/10.1016/j.jns.2008.11.004 PMid:19059614 DOI: https://doi.org/10.1016/j.jns.2008.11.004

Benbir G, Ince B, Bozluolcay M. The epidemology of post stroke epilepsy according to stroke subtypes. Acta Neurol Scand. 2006;114(1):8-12. https://doi.org/10.1111/j.1600-0404.2006.00642.x PMid:16774620 DOI: https://doi.org/10.1111/j.1600-0404.2006.00642.x

Giroud M, Gras P, Fayolle H, Andre N, Soichot P, Dumas R. Early seizures after acute stroke: A study of 1,640 cases. Epilepsia. 1994;35(5):959-64. https://doi.org/10.1111/j.1528-1157.1994.tb02540.x PMid:7925167 DOI: https://doi.org/10.1111/j.1528-1157.1994.tb02540.x

Chadehumbe MA, Khatri P, Khoury JC, Alwell K, Szaflarski JP, Broderick JP, et al. Seizures are common in the acute setting of childhood stroke: A population-based study. J Child Neurol. 2009;24(1):9-12. https://doi.org/10.1177/0883073808320756 PMid:18923086 DOI: https://doi.org/10.1177/0883073808320756

Brigo F, Tezzon F, Nardone R. Late-onset seizures and risk of subsequent stroke: A systematic review. Epilepsy Behav. 2014;31:9-12. https://doi.org/10.1016/j.yebeh.2013.11.003 PMid:24291522 DOI: https://doi.org/10.1016/j.yebeh.2013.11.003

Cleary P, Shorvon S, Tallis R. Late-onset seizures as a predictor of subsequent stroke. Lancet J. 2004;363(9416):1184-6. https://doi.org/10.1016/S0140-6736(04)15946-1 PMid:15081649 DOI: https://doi.org/10.1016/S0140-6736(04)15946-1

Pitkanen A, Roivainen R, Lukasiuk K. Development of epilepsy after ischaemic stroke. Lancet Neurol. 2015;15(2):185-97. https://doi.org/10.1016/S1474-4422(15)00248-3 PMid:26597090 DOI: https://doi.org/10.1016/S1474-4422(15)00248-3

Gasparini S, Ferlazzo E, Beghi E, Sofia V, Mumoli L, Labate A, et al. Epilepsy associated with leukoaraiosis mainly affects temporal lobe: A casual or causal relationship. Epilepsy Res. 2015;109:1-8. https://doi.org/10.1016/j.eplepsyres.2014.10.012 PMid:25524836 DOI: https://doi.org/10.1016/j.eplepsyres.2014.10.012

Pantoni L. Cerebral small vessel disease: From pathogenesis and clinical characteristics to therapetic challenges. Lancet Neurol. 2010;9(7):689-701. https://doi.org/10.1016/ S1474-4422(10)70104-6 PMid:20610345 DOI: https://doi.org/10.1016/S1474-4422(10)70104-6

Cvetkovska D, Taravari A, Baneva ND. Intracerebral hemorrhage and epileptic seizures: Frequency, localization and seizures types. Proj Intracerebral Hemorrhage. 2017;71(2):119-22. DOI: https://doi.org/10.1515/mmr-2017-0020

Tanaka T, Ihara M. Post stroke epilepsy. Neurochem Int. 2017;107:217-28. https://doi.org/10.1016/j.neuint.2017.02.002 PMid:28202284 DOI: https://doi.org/10.1016/j.neuint.2017.02.002

Naydenov C, Manolova T, Chavdarov S, Manchev I. Cerebrovascular diseases and seizures. AQ6???. 2018;5(107):2-5.

Hristiva D, Andonova S. Frequency and Characteristics of Epileptic Seizures in Acute Stage of Stroke. Varna Medical Forum, т. 2017:(6):13-5. http://doi.org/10.14748/vmf.v6i1.2025 DOI: https://doi.org/10.14748/vmf.v6i1.2025

De Reuck J. Stroke-related seizures and epilepsy. Neurol Neurochir Pol. 2007;41:144-9. PMid:17530577

Pezzini A, Grassi M, Del Zotto E, Giossi A, Volonghi I, Costa P, et al. Complications of acute stroke and the occurrence of early seizures. Cerebrovasc Dis. 2013;35:444-50. https://doi.org/10.1159/000348704 DOI: https://doi.org/10.1159/000348704

Zelano J, Larsson D, Kumlien E, Åsberg S. Pre-stroke seizures: A nationwide register-based investigation. Seizure. 2017;49:25-9. https://doi.org/10.1016/j.seizure.2017.05.010 PMid:28544888 DOI: https://doi.org/10.1016/j.seizure.2017.05.010

Kopyta I, Sareska-Hujar B, Skrzypek M. Post-stroke epilepsy in polish paediatric patients. Dev Med Child Neurol. 2015;57(9):821-8. https://doi.org/10.1111/dmcn.12711.Epub 2015 Feb 18 PMid:25692742 DOI: https://doi.org/10.1111/dmcn.12711

Silverman IE, Restrepo L, Mathews GC. Post-stroke seizures. Arch Neurol. 2002;59(2):195-201. https://doi.org/10.1001/archneur.59.2.195 PMid:11843689 DOI: https://doi.org/10.1001/archneur.59.2.195

Awada A, Omojola MF, Obeid T. Late epileptic seizures after cerebral infarction. Acta Neurol Scand. 1999;99(5):265-8. https://doi.org/10.1111/j.1600-0404.1999.tb00674.x PMid:10348154 DOI: https://doi.org/10.1111/j.1600-0404.1999.tb00674.x

Szaflarski JP, Rackley AY, Kleindorfer DO, Khoury J, Woo D, Miller R, et al. Incidence of seizures in the acute phase of stroke: A population-based study. Epilepsia. 2008;49(6):974-81. https://doi.org/10.1111/j.1528-1167.2007.01513.x PMid:18248443 DOI: https://doi.org/10.1111/j.1528-1167.2007.01513.x

Hitiris N, Mohanraj R, Norrie J, Brodie MJ. Mortality in epilepsy. Epilepsy Behav. 2007;10(3):363-76. https://doi.org/10,1016/j.yebeh.2007,01.005 PMid:17337248 DOI: https://doi.org/10.1016/j.yebeh.2007.01.005

Feldenkrais M. In: Shorvon S, Perucca E, Engel J Jr., editors. Foreword: The Treatment of Epilepsy. 3rd ed. Chichester, UK: Wiley-Blackwell; 2009.

Bagary M. Epilepsy, antiepileptic drugs and suicidality. Curr Opin Neurol. 2011;24(2):177-82. https://doi.org/10,1097/WCO.0b013e328344533e PMid:21293270 DOI: https://doi.org/10.1097/WCO.0b013e328344533e

Mula M, Sander JW. Suicide risk in people with epilepsy taking antiepileptic drugs. Bipolar Disord. 2013;15(5):622-7. https://doi.org/10,1111/bdi.12091 PMid:23755740 DOI: https://doi.org/10.1111/bdi.12091

Arboix A, Comes E, García-Eroles L, Massons JB, Oliveres M, Balcells M. Prognostic value of very early seizures for in-hospital mortality in atherothrombotic infarction. Eur Neurol. 2003;50(2):78-84. https://doi.org/10.1159/000072503 PMid:12944711 DOI: https://doi.org/10.1159/000072503

Vernino S, Brown R Jr., Sejvar J, Sicks J, Petty G, O’Fallon W. Cause-specific mortality after first cerebral infarction-a population-based study. Stroke. 2003;34:1828-32. https://doi.org/10.1161/01.STR.0000080534.98416.A0 PMid:12855836 DOI: https://doi.org/10.1161/01.STR.0000080534.98416.A0

Guekht A, Khaimovsky L, Gulyaeva NV, Lebedeva AV, Shpak AA, Hauser AW, et al. Risk factors and prognosis of early seizures after haemorrhage and ischemic stroke. J Neurol Sci. 2009;285(Suppl 1):S112. https://doi.org/10.1016/S0022-510X(09)70451-4 DOI: https://doi.org/10.1016/S0022-510X(09)70451-4

Guekht A. Seizures and Epilepsy in Stroke Patients: Epidemiology, Risk Factors, Outcomes. Germany: European Stroke Organisation, ESO-WSO; 2020.

Kilpatrick CJ, Davis SM, Tress BM, Rossiter SC, Hopper JL, Vandendriesen ML. Epileptic seizures in acute strokes. Arch Neurol. 1990;47(2):157-60. https://doi.org/10.1001/archneur.1990.00530020053014 PMid:2302087 DOI: https://doi.org/10.1001/archneur.1990.00530020053014

Velioglu SK, Ozmenoglu M, Boz C, Alioglu Z. Status epilepticus after stroke. Stroke. 2001;32:1169-72. https://doi.org/10.1161/01.str.32.5.1169 PMid:11340227 DOI: https://doi.org/10.1161/01.STR.32.5.1169

Bateman BT, Claassen J, Willey JZ, Hirsch LJ, Mayer SA, Sacco RL, et al. Convulsive status epilepticus after ischemic stroke and intracerebral hemorrhage: Frequency, predictors, and impact on outcome in a large administrative dataset. Neurocrit Care. 2007;7(3):187-93. https://doi.org/10.1007/s12028-007-0056-2 PMid:17503112 DOI: https://doi.org/10.1007/s12028-007-0056-2

Rumbach L, Sablot D, Berger E, Tatu L, Vuillier F, Moulin T. Status epilepticus in stroke: Report on a hospital-based stroke cohort. Neurology. 2000;54(2):350-4. https://doi.org/10.1212/wnl.54.2.350 PMid:10668695 DOI: https://doi.org/10.1212/WNL.54.2.350

Belcastro V, Vidale S, Gorgone G, Pisani LR, Sironi L, Arnaboldi M, et al. Non-convulsive status epilepticus after ischemic stroke: A hospital-based stroke cohort study. J Neurol 2014;261(11):2136-42. https://doi.org/10.1007/s00415-014-7471-z PMid:25138478 DOI: https://doi.org/10.1007/s00415-014-7471-z