Antibiotic susceptibility of Helicobacter pylori isolates in Dakar, Senegal
DOI:
https://doi.org/10.3855/jidc.512Keywords:
Helicobacter pylori, antimicrobial susceptibility, SenegalAbstract
Background: Helicobacter pylori is the primary cause of peptic ulcer disease and an etiologic agent in the development of gastric cancer. A high frequency of H. pylori infection has been reported from resource-poor regions. H. pylori infection is curable with regimens of multiple antimicrobial agents. However, antibiotic resistance is a leading cause of treatment failure. In Africa, there are very little data concerning the susceptibility of H. pylori isolates to antibiotics.Methodology: H. pylori isolates from gastric biopsies from outpatients ≥ 18 years old affected by a gastro-duodenal ulcer were used in this study. Susceptibility testing was performed for amoxicillin, ciprofloxacin and metronidazole by using the Epsilometer test (E-test) method.
Results: H. pylori strains were isolated from 40 patients of whom 36 were diagnosed as having duodenal ulcer, two with gastric ulcer, and two with gastro-duodenal ulcer. Thirty-six (90%) of the isolates were resistant to metronidazole (MICs ≥ 8 µg/l), whereas all isolates were susceptible to amoxicillin (MICs ≤ 0. 5 µg/ml) and ciprofloxacin (MICs ≤ 1µg/ml).
Conclusion: These data suggest that metronidazole should not be used therapeutically among Senegalese patients in first-line therapy, while ciprofloxacin could be recommended in association with amoxicillin and a proton pump inhibitor in Senegal.
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Seck A, Mbengue M, Gassama-Sow A, Diouf L, Ka MM, Boye CS-B (2009) Antibiotic susceptibility of Helicobacter pylori isolates in Dakar, Senegal. J Infect Dev Ctries 3:137–140. doi: 10.3855/jidc.512
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