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Bioengineering

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JoVE Journal Bioengineering
3D Cell-Printed Hypoxic Cancer-on-a-Chip for Recapitulating Pathologic Progression of Solid Cancer
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3D Cell-Printed Hypoxic Cancer-on-a-Chip for Recapitulating Pathologic Progression of Solid Cancer

Article DOI: 10.3791/61945-v • 10:51 min • January 5th, 2021
January 5th, 2021 •
*1, *1, 1, 2, 1, 1,3
1Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), 2Department of Creative IT Engineering, Pohang University of Science and Technology (POSTECH), 3Department of Rural and Biosystems Engineering, College of Agriculture and Life Sciences, Chonnam National University
* These authors contributed equally

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Summary
Automatic Translation

Hypoxia is a hallmark of tumor microenvironment and plays a crucial role in cancer progression. This article describes the fabrication process of a hypoxic cancer-on-a-chip based on 3D cell-printing technology to recapitulate a hypoxia-related pathology of cancer.

Tags

3D Cell-printing Hypoxic Cancer-on-a-chip Solid Cancer Pathologic Progression Genomic Instability Tumorigenesis 3D Bioprinting Technology Gas Permeable Barrier Glass Cover Drug Efficacy Patient Specific Anticancer Drug Prescription Quick Diagnosis Neutralized Collagen Pre-gel Solution Collagen Sponges Hydrochloric Acid PH Adjustment Phenol Red Solution PBS
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