Basic Study on Enhancement of Antioxidant Function by Low-dose Irradiation in Mouse Brain and Its Combined Effect with Ascorbic Acid

Takahiro Kataoka; Yuto Yunoki; Norie Kanzaki; Kaori Sasaoka; Yusuke Kobashi; Tsuyoshi Ishida; Katsumi Hanamoto; Kiyonori Yamaoka

doi:10.3769/radioisotopes.69.45

Article

Basic Study on Enhancement of Antioxidant Function by Low-dose Irradiation in Mouse Brain and Its Combined Effect with Ascorbic Acid

Takahiro Kataoka , Yuto Yunoki, Norie Kanzaki, Kaori Sasaoka, Yusuke Kobashi, Tsuyoshi Ishida, Katsumi Hanamoto, Kiyonori Yamaoka

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Keywords: low-dose X-ray, ascorbic acid, mouse brain, lipid peroxide level, superoxide dismutase (SOD) activity, heat shock protein (HSP) level

JOURNAL OPEN ACCESS

2020 Volume 69 Issue 2 Pages 45-53

DOI https://doi.org/10.3769/radioisotopes.69.45

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Abstract

We studied on the characteristics of changes in antioxidant function of mice brains at 4 h to 7 days after low-dose X-ray (0.1 to 2.0 Gy) irradiation, and the combination effect of this and administration of ascorbic acid (500 mg/kg body weight), an antioxidant enzyme. As a result, low-dose irradiation mostly showed decrease in lipid peroxide levels, increase in superoxide dismutase (SOD) activities and heat shock protein (HSP) levels. In addition, the combined use of 0.5 Gy irradiation with ascorbic acid administration showed a significant decrease in lipid peroxide level, suggesting the combined effect of antioxidant.

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