Abstract
In two experiments, we tested the hypothesis that medial temporal lobe (MTL) amnesic patients and, likewise, diencephalic (DNC) amnesic patients evidence a disproportionate deficit in memory for associations in comparison with memory for single items. In Experiment 1, we equated item recognition in amnesic and control participants and found that, under these conditions, associative recognition remained impaired both for MTL patients and for DNC patients. To rule out an alternative interpretation of the results of Experiment 1, in Experiment 2 we compared the performance of amnesic and control participants on a one-item recognition task and a two-item recognition task that required no memory for the association between members of word pairs. In the MTL group, when single-item recognition was equated to that of the controls, two-item nonassociative pair memory was equivalent as well. In the DNC group, nonassociative pair memory was impaired, but this impairment did not fully account for the impairment in associative memory. These findings indicate that memory for novel associations between items is disproportionately impaired in comparison with memory for single items in amnesia.
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Benton, A. L., & Hamsher, K. D. (1989). Multilingual aphasia examination. Iowa City, IA: AJA Associates.
Cermak, L. (1976). The encoding capacity of a patient with amnesia due to encephalitis. Neuropsychologia, 14, 311–326.
Chalfonte, B. L., Verfaellie, M., Johnson, M. K., & Reiss, L. (1996). Spatial location memory in amnesia: Binding item and location information under incidental and intentional encoding conditions. Memory, 4, 591–614.
Chun, M. M., & Phelps, E. A. (1999). Memory deficits for implicit contextual information in amnesic subjects with hippocampal damage. Nature Neuroscience, 2, 844–847.
Cowey, C. M., & Green, S. (1996). The hippocampus: A “working memory” structure? The effect of hippocampal sclerosis on working memory. Memory, 4, 19–30.
Eichenbaum, H., Alvarez, P., & Ramus, S. J. (2000). Animal models of amnesia. In L. S. Cermak (Ed.), Memory and its disorders (2nd ed., Vol. 2, pp. 1–24). Amsterdam: Elsevier.
Eichenbaum, H., & Cohen, N. J. (2001). From conditioning to conscious recollection: Memory systems of the brain. New York: Oxford University Press.
Fazio, F., Perani, D., Gilardi, M. C., Colombo, F., Cappa, S. F., Vallar, G., Bettinardi, V., Paulesu, E., Alberoni, M., Bressi, S., Franceschi, M., & Lenzi, G. L. (1992). Metabolic impairment in human amnesia: A PET study of memory networks. Journal of Cerebral Blood Flow & Metabolism, 12, 353–358.
Francis, W. N., & Kucï era, H. (1982). Frequency analysis of English usage: Lexicon and grammar. Boston: Houghton Mifflin.
Fried, I., MacDonald, K. A., & Wilson, C. L. (1997). Single neuron activity in human hippocampus and amygdala during recognition of faces and objects. Neuron, 18, 753–765.
Giovanello, K. S., & Verfaellie, M. (2001). The relationship between recall and recognition in amnesia: Effects of matching recognition between patients with amnesia and controls. Neuropsychology, 15, 444–451.
Grant, D. A., & Berg, E. A. (1948). A behavioral analysis of the degree of reinforcement and ease of shifting to new responses in a Weigl-type card sorting problem. Journal of Experimental Psychology: General, 38, 404–411.
Heiss, W. D., Pawlik, G., Holthoff, V., Kessler, J., & Szelies, B. (1992). PET correlates of normal and impaired memory function. Cerebrovascular Brain Metabolism Review, 4, 1–27.
Henke, K., Buck, A., Weber, B., & Wieser, H.G. (1997). Human hippocampus establishes associations in memory. Hippocampus, 7, 249–256.
Hockley, W. E., & Consoli, A. (1999). Familiarity and recollection in item and associative recognition. Memory & Cognition, 27, 657–664.
Isaac, C. L., & Mayes, A. R. (1999a). Rate of forgetting in amnesia: I. Recall and recognition of prose. Journal of Experimental Psychology: Learning, Memory, & Cognition, 25, 942–962.
Isaac, C. L., & Mayes, A. R. (1999b). Rate of forgetting in amnesia: II. Recall and recognition of word lists at different levels of organization. Journal of Experimental Psychology: Learning, Memory, & Cognition, 25, 963–977.
Jernigan, T. L., Shafer, K., Butters, N., & Cermak, L. S. (1991). Magnetic resonance imaging of alcoholic Korsakoff patients. Neuropsychopharmacology, 4, 175–186.
Kroll, N. E. A., Knight, R. T., Metcalfe, J., Wolf, E. S., & Tulving, E. (1996). Conjunction failure as a source of memory illusions. Journal of Memory & Language, 35, 176–196.
Mayes, A. R., Isaac, C. L., Holdstock, J. S., Hunkin, N. M., Montaldi, D., Downes, J. J., MacDonald, C., Cezayirli, E., & Roberts, J. N. (2001). Memory for single items, word pairs, and temporal order of different kinds in a patient with selective hippocampal lesions. Cognitive Neuropsychology, 18, 97–123.
Mitchell, K. J., Johnson, M. K., Raye, C. L., & D'Esposito, M. (2000). fMRI evidence of age-related hippocampal dysfunction in feature binding working memory. Cognitive Brain Research, 10, 197–206.
Norman, K. A., & O'Reilly, R. C. (in press). Modeling hippocampal and neocortical contributions to recognition memory: A complementary learning systems approach. Psychological Review.
O'Connor, M., & Verfaellie, M. (2002). The amnesic syndrome: Overview and subtypes. In A. Baddeley, M. D. Kopelman, & B. A. Wilson (Eds.), The handbook of memory disorders (pp. 145–166). Chichester, U.K.: Wiley.
Reinitz, M. T., Verfaellie, M., & Milberg, W. P. (1996). Memory conjunction errors in normal and amnesic subjects. Journal of Memory & Language, 35, 286–299.
Ryan, J. D., Althoff, R.R., Whitlow, S., & Cohen, N. J. (2000). Amnesia is a deficit in relational memory. Psychological Science, 11, 454–461.
Spreen, O., & Strauss, E. (1991). A compendium of neuropsychological tests. New York: Oxford University Press.
Stark, C. E., Bayley, P. J., & Squire, L. R. (2002). Recognition memory for single items and for associations is similarly impaired following damage to the hippocampal region. Learning & Memory, 9, 238–242.
Stark, C. E., & Squire, L. R. (2001). Simple and associative recognition memory in the hippocampal region. Learning & Memory, 8, 190–197.
Stark, C. E., & Squire, L. R. (2003). Hippocampal damage equally impairs memory for single items and memory for conjuctions. Hippocampus, 13, 281–292.
Vargha-Khadem, F., Gadian, D. G., Watkins, K. E., Connelly, A., Van Paesschen, W., & Mishkin, M. (1997). Differential effects of early hippocampal pathology on episodic and semantic memory. Science, 277, 376–380.
Victor, M., Adams, R. D., & Collins, G. H. (1989). The Wernicke-Korsakoff syndrome and related neurologic disorders due to alcoholism and malnutrition (2nd ed.). Philadelphia: Davis.
Wechsler, D. (1997a). Wechsler Adult Intelligence Scale—Third edition: Administration and scoring manual. San Antonio, TX: Psychological Corp.
Wechsler, D. (1997b). Wechsler Memory Scale—Third edition: Administration and scoring manual. San Antonio, TX: Psychological Corp.
Winocur, G., & Weiskrantz, L. (1976). An investigation of pairedassociate learning in amnesia. Neuropsychologia, 14, 97–110.
Yonelinas, A. P., Hopfinger, J. B., Buonocore, M. H., Kroll, N. E. A., & Baynes, K. (2001). Hippocampal, parahippocampal and occipital-temporal contributions to associative and item recognition memory: An fMRI study. NeuroReport, 12, 359–363.
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This research was supported by National Institute of Mental Health Grants MH57681 and MH65113, National Institute of Neurological Disorders and Stroke Grant NS26985, and the Medical Research Service of the United States Department of Veterans Affairs.
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Giovanello, K.S., Verfaellie, M. & Keane, M.M. Disproportionate deficit in associative recognition relative to item recognition in global amnesia. Cognitive, Affective, & Behavioral Neuroscience 3, 186–194 (2003). https://doi.org/10.3758/CABN.3.3.186
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DOI: https://doi.org/10.3758/CABN.3.3.186