Abstract
Daily amygdaloid stimulation administered to rats at current levels initially too low to produce a motor response but high enough to produce an electrographic afterdischarge (AD) resulted in the progressive development and intensification of stimulus-induced epileptic activity (kindling). In contrsst to previous studies, however, stimulation was continued long after the point where the exacerbation of motor seizures (MSs) seemed complete. Several animals were stimulated for up to 7 months and, with continued stimulation, an epileptic syndrome characterized by spontaneous motor seizures was observed to develop.
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Goddard, G. V. Development of epileptic seizures through brain stimulation at low intensity. Nature, 1967, 214, 1020–1021.
Goddard, G. V. The kindling effect: A precautionary note on therapeutic applications of localized brain stimulation. In D. V. Reynolds and A. E. Sjoberg (Eds.), Neuroelectric research: Electroneuroprosthesis, electroanesthesia and non-convulsive electrotherapy. Springfield: Thomas, 1971.
Goddard, G. V., & Morrell, F. Chronic progressive epileptogenesis induced by focal stimulation on the brain. Neurology, 1971, 21, 393.
Goddard, G., McIntyre, D., & Leech, C. A permanent change in brain function resulting from daily electrical stimulation. Experimental Neurology, 1969, 25, 295–330.
Heath, R. G. Perspectives for biological psychiatry: Presidential address. Biological Psychiatry, 1970, 2, 81–88.
Jackson, J. H. A study of convulsions. In: J. Taylor (Ed.), Selected readings of John Hughlings Jackson Vol. 1. 1870. Reprinted New York: Basic Books, 1958.
Leech, C. K. Comparison of audiogenic seizure development and kindled convulsions in seven strains of mouse. Doctoral Dissertation, Dalhousie University, 1972.
Morrell, F. Goddard’s kindling phenomenon: A new model of the “mirror focus.”. In: H. C. Sabelli (Ed.), Chemical modulation of brain function. New York: Raven, 1973.
Racine, R. J. Modification of seizure activity by electrical stimulation: II. Motor seizure. Electroencephalography and Clinical Neurophysiology, 1972, 32, 281–294.
Tanaka, A. Progressive changes of behavioral and electroencephalographic responses to daily amygdaloid stimulation in rabbits. Fukuoka Acts Medica, 1972, 63, 152–164.
Wada, J. A., & Sato, M. Generalized convulsive seizure state induced by daily stimulation of the amygdala in split-brain cats. Paper presented at the 27th annual meeting of the American Electroencephalographic Society, Boston, 1973.
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Supported by National Research Council Grants APS 7809 and APA 7808 awarded to John Pinel and A. G. Phillips, respectively.
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Pinel, J.P.J., Mucha, R.F. & Phillips, A.G. Spontaneous seizures generated in rats by kindling: A preliminary report. Psychobiology 3, 127–129 (1975). https://doi.org/10.3758/BF03337488
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DOI: https://doi.org/10.3758/BF03337488