Cudrania tricuspidata Extract Protects against Reflux Esophagitis by Blocking H₂ Histamine Receptors

Joo Yun Kim; Sung Sik Jang; Jung Lyoul Lee; Jae-Hun Sim; Jae-Jung Shim

doi:10.3746/pnf.2019.24.2.159

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저널정보

한국식품영양과학회
Preventive Nutrition and Food Science 학술저널
Preventive Nutrition and Food Science Vol.24 No.2
2019.6 159 - 164 (6page)
DOI : 10.3746/pnf.2019.24.2.159

저자정보

Joo Yun Kim (Korea Yakult)
Sung Sik Jang (Korea Yakult)
Jung Lyoul Lee (Korea Yakult)
Jae-Hun Sim (Korea Yakult)
Jae-Jung Shim (Korea Yakult)

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Cudrania tricuspidata has been used in East Asia as a folk medicine for symptoms such as inflammation, allergy, and gastritis. Administration of C. tricuspidata extract to pylori-ligated rat stomachs reduces gastric acid secretion and alleviates esophagus damage caused by gastric reflux. Therefore, in this study we aimed to investigate whether C. tricuspidata extracts inhibit reflux esophagitis by blocking H2 histamine receptor (H₂R). Dimaprit, a H₂R specific agonist, induced intracellular cyclic adenosine monophosphate (cAMP) production in U937 cells. Pretreatment with C. tricuspidata extracts significantly blocked dimaprit-induced cAMP production in a concentration-dependent manner. To extracted C. tricuspidata with different ethanol concentrations to determine the optimum method. We found that the 70% ethanol extract showed the most potent H₂R antagonistic effect against dimaprit-induced cAMP production. However, water extract did not show any H₂R blocking effect. These findings suggest that C. tricuspidata extracted using ethanol specifically inhibits gastric acid secretion and reduces esophageal injury by blocking H₂R in a competitive manner. Therefore, C. tricuspidata extracts may be used in food or medicine to prevent H2R-related diseases, such as gastric hyperacidity and reflux esophagitis.

#Cudrania tricuspidata #H2 histamine receptor #reflux esophagitis #gastric juice secretion #gastric hyperacidity