Serum Amino Acids Imbalance in Canine Chronic Hepatitis: Results in 16 Dogs
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Population and Sample Preparation
2.2. Statistical Analysis
3. Results
3.1. Animals
3.2. Serum Amino Acids
3.3. Histological Scores
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Appendix A
Clinical Pathological Variable | Median (Range) | Reference Interval |
ALP | 433 (122–2704) | 45–250 |
GGT | 7.3 (1.6–21.9) | 2–11 |
AST | 81.7 (24–565) | 15–40 |
ALT | 205 (64–987) | 40–185 |
Total serum proteins | 6.15 (4.4–8.5) | 5.8–7.8 |
Albumin | 3.2 (2.1–4.3) | 2.6–4.1 |
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Amino Acid | Group CH | Group C | p Value |
---|---|---|---|
GLY | 70.6 ± 21.8 | 48 ± 16.47 | 0.0006 |
ALA | 78.7 (28.8–140.7) | 94.5 (56.6–225.9) | 0.06 |
VAL | 34.9 (17.8–63.3) | 4.8 (3–14.2) | <0.0001 |
LEU | 26.7 (8.6–51.7) | 10.7 (7.8–34.4) | <0.0001 |
ILE | 9.3 ± 3.6 | 26.1 ± 8.3 | <0.0001 |
PRO | 55.9 (22.96–76.46) | 6.3 (3.9–67.46) | <0.0001 |
SER | 58.5 ± 23.6 | 41.3 ± 14.7 | 0.006 |
THR | 45.4 (26.8–78.1) | 50.2 (30.5–99.7) | 0.2 |
CYS | 5.8 ± 1.3 | 38.3 ± 15.3 | <0.0001 |
MET | 8.6 (3.4–36.6) | 4.8 (0.3–58.5) | 0.003 |
PHE | 25.3 (10.4–63.1) | 10.9 (4.5–24.6) | <0.0001 |
TYR | 20.5 (11.42–67.72) | 11.3 (6.3–54) | 0.0008 |
TRP | 19.8 (9.9–33.8) | 48.2(19.7–108.3) | <0.0001 |
ASP | 1.4 (0.14–5.36) | 1.28 (0.16–5.46) | 0.7 |
GLU | 19.2 (4.9–102.6) | 8.8 (4.4–20.6) | 0.001 |
HIS | 246.8 ± 82.7 | 198 ± 58.8 | 0.03 |
LYS | 55.9 (29.1–96.4) | 7.3(3.8–64.1) | <0.0001 |
ARG | 54.2 (24.9–79.9) | 59.2 (0.06–172.5) | 0.6 |
BCAAs/AAAs ratio | 1.89 (0.38–2.96) | 1.72 (0.69–3.24) | 0.9 |
Score | A Score (n = 16) | F Score (n = 16) |
---|---|---|
0 | 0 | 4 |
1 | 6 | 2 |
2 | 6 | 6 |
3 | 1 | 1 |
4 | 1 | 3 |
5 | 2 | / |
Total | 16 | 16 |
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Habermaass, V.; Gori, E.; Abramo, F.; Bartoli, F.; Pierini, A.; Mariti, C.; Lippi, I.; Marchetti, V. Serum Amino Acids Imbalance in Canine Chronic Hepatitis: Results in 16 Dogs. Vet. Sci. 2022, 9, 455. https://doi.org/10.3390/vetsci9090455
Habermaass V, Gori E, Abramo F, Bartoli F, Pierini A, Mariti C, Lippi I, Marchetti V. Serum Amino Acids Imbalance in Canine Chronic Hepatitis: Results in 16 Dogs. Veterinary Sciences. 2022; 9(9):455. https://doi.org/10.3390/vetsci9090455
Chicago/Turabian StyleHabermaass, Verena, Eleonora Gori, Francesca Abramo, Francesco Bartoli, Alessio Pierini, Chiara Mariti, Ilaria Lippi, and Veronica Marchetti. 2022. "Serum Amino Acids Imbalance in Canine Chronic Hepatitis: Results in 16 Dogs" Veterinary Sciences 9, no. 9: 455. https://doi.org/10.3390/vetsci9090455