Immunoengineering via Chimeric Antigen Receptor-T Cell Therapy: Reprogramming Nanodrug Delivery
Abstract
:1. Introduction
2. Molecular Structure of CARs
3. Current Obstacles in CAR-T Cell Therapy
4. Nanotherapy-Related CAR Therapy
5. Nano-Induced T Cell Editing
6. In Vivo Reprogramming of CART Cells
7. Future Challenges
8. Conclusions
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Nano Type | Drug Compound | Target | Tumor Type | Status | Trial Number |
---|---|---|---|---|---|
Lipid NPs | mRNA-2752 | OX40L, IL-23, and IL-36γ | Squamous-cell bladder carcinoma | Recruiting | NCT03739931 |
NPs | anti-VEGFR2 | VEGFR2 | Metastatic Renal Cancer | Terminated | NCT01218867 |
Lipid NPs | mRNA-2416 | OX40L | Refractory Solid Tumor | Terminated | NCT03323398 |
Liposomal nanodrug | L-BLP25 | MUC1 | Metastatic colorectal carcinoma | Completed | NCT01462513 |
Liposomal nanodrug | RNA-drug | TME specific antigens | Ovarian Carcinoma | Active, not recruiting | NCT04163094 |
Hafnium oxide nanoparticles | NBTXR3 | PD-L1 | Cervical cancer | Recruiting | NCT03589339 |
NPs | Paclitaxel | PD-L1 | Metastatic triple-negative breast cancer | Completed | NCT02425891 |
NPs | MEDI6469 | OX40 | Head and Neck Cancer | Active, not recruiting | NCT02274155 |
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Katopodi, T.; Petanidis, S.; Anestakis, D.; Charalampidis, C.; Chatziprodromidou, I.; Floros, G.; Eskitzis, P.; Zarogoulidis, P.; Koulouris, C.; Sevva, C.; et al. Immunoengineering via Chimeric Antigen Receptor-T Cell Therapy: Reprogramming Nanodrug Delivery. Pharmaceutics 2023, 15, 2458. https://doi.org/10.3390/pharmaceutics15102458
Katopodi T, Petanidis S, Anestakis D, Charalampidis C, Chatziprodromidou I, Floros G, Eskitzis P, Zarogoulidis P, Koulouris C, Sevva C, et al. Immunoengineering via Chimeric Antigen Receptor-T Cell Therapy: Reprogramming Nanodrug Delivery. Pharmaceutics. 2023; 15(10):2458. https://doi.org/10.3390/pharmaceutics15102458
Chicago/Turabian StyleKatopodi, Theodora, Savvas Petanidis, Doxakis Anestakis, Charalampos Charalampidis, Ioanna Chatziprodromidou, George Floros, Panagiotis Eskitzis, Paul Zarogoulidis, Charilaos Koulouris, Christina Sevva, and et al. 2023. "Immunoengineering via Chimeric Antigen Receptor-T Cell Therapy: Reprogramming Nanodrug Delivery" Pharmaceutics 15, no. 10: 2458. https://doi.org/10.3390/pharmaceutics15102458