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Volume 13
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Reply to Nutrients 2021, 13(6), 2119.
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Reply to Ravnskov, U. Is High Cholesterol Deleterious? An Alternative Point of View. Comment on “Burén et al. A Ketogenic Low-Carbohydrate High-Fat Diet Increases LDL Cholesterol in Healthy, Young, Normal-Weight Women: A Randomized Controlled Feeding Trial. Nutrients 2021, 13, 814”

by
Jonas Burén
1,2,*,
Madelene Ericsson
3,4,
Nágila Raquel Teixeira Damasceno
5 and
Anna Sjödin
1
1
Department of Food, Nutrition and Culinary Science, Umeå University, 90187 Umeå, Sweden
2
Department of Public Health and Clinical Medicine, Medicine, Umeå University, 90187 Umeå, Sweden
3
Department of Medical Biosciences, Physiological Chemistry, Umeå University, 90187 Umeå, Sweden
4
Umeå Centre for Molecular Medicine, Umeå University, 90187 Umeå, Sweden
5
Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo 05508-060, Brazil
*
Author to whom correspondence should be addressed.
Nutrients 2021, 13(7), 2127; https://doi.org/10.3390/nu13072127
Submission received: 10 June 2021 / Accepted: 16 June 2021 / Published: 22 June 2021
Versions Notes
We thank Ravnskov [1] for his interest in our recent publication [2]. In our study, low-density lipoprotein cholesterol (LDL-C) and Apolipoprotein B-100 (ApoB) almost doubled in young, healthy women when they followed the ketogenic low-carbohydrate high-fat (LCHF) diet. According to the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS) Guidelines for the management of dyslipidaemias [3] “…there is no longer an ‘LDL-C hypothesis’, but established facts that increased LDL-C values are causally related to atherosclerotic cardiovascular disease, and that lowering LDL particles and other ApoB-containing lipoproteins as much as possible reduces cardiovascular events.” Therefore, we think it is reasonable to conclude that the alterations in blood lipids reported in our study should be a cause for concern in young women following this kind of LCHF diet.

Author Contributions

Writing—original draft preparation, J.B., M.E., N.R.T.D. and A.S. All authors have read and agreed to the published version of the manuscript.

Funding

This work was supported by P.Håkansson’s Foundation, Eslöv, Sweden, and by Magnus Bergvall’s Foundation, grant number 2014-00411, Sweden. The authors have not received any funding or benefits from commercial organizations.

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. Ravnskov, U. Is High Cholesterol Deleterious? An Alternative Point of View. Comment on Burén et al. A Ketogenic Low-Carbohydrate High-Fat Diet Increases LDL Cholesterol in Healthy, Young, Normal-Weight Women: A Randomized Controlled Feeding Trial. Nutrients 2021, 13, 814. Nutrients 2021, 13, 2119. [Google Scholar] [CrossRef]
  2. Burén, J.; Ericsson, M.; Damasceno, N.R.T.; Sjödin, A. A ketogenic low-carbohydrate high-fat diet increases LDL cholesterol in healthy, young, normal-weight women: A randomized controlled feeding trial. Nutrients 2021, 13, 814. [Google Scholar] [CrossRef] [PubMed]
  3. Mach, F.; Baigent, C.; Catapano, A.L.; Koskinas, K.C.; Casula, M.; Badimon, L.; Chapman, M.J.; De Backer, G.G.; Delgado, V.; Ference, B.A.; et al. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: Lipid modification to reduce cardiovascular risk. Eur. Heart J. 2020, 41, 111–188. [Google Scholar] [CrossRef] [PubMed]
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MDPI and ACS Style

Burén, J.; Ericsson, M.; Damasceno, N.R.T.; Sjödin, A. Reply to Ravnskov, U. Is High Cholesterol Deleterious? An Alternative Point of View. Comment on “Burén et al. A Ketogenic Low-Carbohydrate High-Fat Diet Increases LDL Cholesterol in Healthy, Young, Normal-Weight Women: A Randomized Controlled Feeding Trial. Nutrients 2021, 13, 814”. Nutrients 2021, 13, 2127. https://doi.org/10.3390/nu13072127

AMA Style

Burén J, Ericsson M, Damasceno NRT, Sjödin A. Reply to Ravnskov, U. Is High Cholesterol Deleterious? An Alternative Point of View. Comment on “Burén et al. A Ketogenic Low-Carbohydrate High-Fat Diet Increases LDL Cholesterol in Healthy, Young, Normal-Weight Women: A Randomized Controlled Feeding Trial. Nutrients 2021, 13, 814”. Nutrients. 2021; 13(7):2127. https://doi.org/10.3390/nu13072127

Chicago/Turabian Style

Burén, Jonas, Madelene Ericsson, Nágila Raquel Teixeira Damasceno, and Anna Sjödin. 2021. "Reply to Ravnskov, U. Is High Cholesterol Deleterious? An Alternative Point of View. Comment on “Burén et al. A Ketogenic Low-Carbohydrate High-Fat Diet Increases LDL Cholesterol in Healthy, Young, Normal-Weight Women: A Randomized Controlled Feeding Trial. Nutrients 2021, 13, 814”" Nutrients 13, no. 7: 2127. https://doi.org/10.3390/nu13072127

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