Catalytic Enantioselective Cyclopropylalkynylation of Aldimines Generated In Situ from α-Amido Sulfones
Abstract
:1. Introduction
2. Results and Discussion
3. Materials and Methods
3.1. General Information
3.2. General Procedure for the Enantioselective Cyclopropylalkynylation of Compounds 1
- Benzyl (S)-(3-cyclopropyl-1-phenylprop-2-yn-1-yl)carbamate (3a)
- Benzyl (S)-(3-cyclopropyl-1-(4-tolyl)prop-2-yn-1-yl)carbamate (3b)
- Benzyl (S)-(3-cyclopropyl-1-(4-fluorophenyl)prop-2-yn-1-yl)carbamate (3c)
- Benzyl (S)-(1-(4-chlorophenyl)-3-cyclopropylprop-2-yn-1-yl)carbamate (3d)
- Benzyl (S)-(1-(4-bromophenyl)-3-cyclopropylprop-2-yn-1-yl)carbamate (3e)
- Benzyl (S)-(3-cyclopropyl-1-(3-tolyl)prop-2-yn-1-yl)carbamate (3f)
- Benzyl (R)-(3-cyclopropyl-1-(2-tolyl)prop-2-yn-1-yl)carbamate (3g)
- Benzyl (R)-(1-(2-chlorophenyl)-3-cyclopropylprop-2-yn-1-yl)carbamate (3h)
- Benzyl (S)-(3-cyclopropyl-1-(naphthalen-2-yl)prop-2-yn-1-yl)carbamate (3i)
- Benzyl (R)-(3-cyclopropyl-1-(furan-2-yl)prop-2-yn-1-yl)carbamate (3j)
- Benzyl (R)-(3-cyclopropyl-1-(thiophen-2-yl)prop-2-yn-1-yl)carbamate (3k)
- Benzyl (R)-(3-cyclopropyl-1-(furan-3-yl)prop-2-yn-1-yl)carbamate (3l)
- Benzyl (S)-(1-cyclopropyl-5-phenylpent-1-yn-3-yl)carbamate (3m)
- Benzyl (S)-(1-cyclopropylhept-1-yn-3-yl)carbamate (3n)
- Benzyl (S)-(1-cyclohexyl-3-cyclopropylprop-2-yn-1-yl)carbamate (3o)
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Sample Availability
References and Notes
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Monleón, A.; Blay, G.; Pedro, J.R. Catalytic Enantioselective Cyclopropylalkynylation of Aldimines Generated In Situ from α-Amido Sulfones. Molecules 2022, 27, 3763. https://doi.org/10.3390/molecules27123763
Monleón A, Blay G, Pedro JR. Catalytic Enantioselective Cyclopropylalkynylation of Aldimines Generated In Situ from α-Amido Sulfones. Molecules. 2022; 27(12):3763. https://doi.org/10.3390/molecules27123763
Chicago/Turabian StyleMonleón, Alicia, Gonzalo Blay, and José R. Pedro. 2022. "Catalytic Enantioselective Cyclopropylalkynylation of Aldimines Generated In Situ from α-Amido Sulfones" Molecules 27, no. 12: 3763. https://doi.org/10.3390/molecules27123763