Impact of Left Ventricular Assist Devices on Days Alive and Out of Hospital in Hemodynamically Stable Patients with End-Stage Heart Failure: A Propensity Score Matched Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Patients
2.3. Propensity Score Matching
2.4. Outcomes
2.5. Statistical Analysis
3. Results
3.1. Propensity Score Matching
3.2. Primary Endpoint
3.3. Secondary Endpoints
4. Discussion
Study Limitations
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Before PSM | After PSM | |||||
---|---|---|---|---|---|---|
LVAD Group (n = 21) | HTx Group (n = 44) | p-Value | LVAD Group (n = 17) | HTx Group (n = 17) | p-Value | |
Age, mean (SD) | 59.97 (6.2) | 55.69 (11.2) | 0.108 | 59.92 (6.7) | 57.70 (7.0) | 0.352 |
Male sex, n (%) | 17 (80.9) | 26 (59.1)) | 0.08 | 13 (76.5) | 12 (70.6) | 0.697 |
BMI, mean (SD) | 28.75 (4.9) | 25.96 (4.2) | 0.021 | 27.30 (3.8) | 27.49 (3.4) | 0.882 |
Renal failure, n (%) | 6 (28.6) | 19 (43.2) | 0.258 | 5 (29.4) | 7 (41.2) | 0.473 |
diagnosis | ||||||
ICM, n (%) | 16 (76.2) | 17 (38.6) | 0.07 | 12 (70.6) | 8 (47.1) | 0.163 |
DCM, n (%) | 5 (23.8) | 22 (50.0) | 5 (29.4) | 9 (52.9) | ||
others, n (%) | 0 (0) | 5 (11.4) | 0 (0) | 0 (0) | ||
NYHA | ||||||
NYHA I, n (%) | 1 (4.8) | 1 (2.3) | 0.608 | 0 (0) | 1 (5.9) | 0.415 |
NYHA II, n (%) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | ||
NYHA III, n (%) | 14 (66.7) | 24 (54.5) | 11 (64.7) | 8 (47.1) | ||
NYHA IV, n (%) | 6 (28.5) | 19 (43.2) | 6 (35.3) | 8 (47.1) | ||
LVEF | ||||||
Preserved (>50%), n (%) | 0 (0) | 1 (2.3) | 0.472 | 0 (0) | 0 (0) | |
Mild reduced (40–49%), n (%) | 0 (0) | 2 (4.5) | 0 (0) | 0 (0) | ||
Reduced (<40%), n (%) | 21 (100) | 41 (93.2) | 17 (100) | 17 (100) |
LVAD Group (n = 17) | HTx Waiting (n = 17) | |
---|---|---|
Survival | ||
1 y survival, n (%) | 14 (82.4) | 13 (76.5) |
3 y survival, n (%) | 13 (76.5) | 10 (58.8) |
Duration until death in days, median (IQR) | 401 (1122) | 314 (279) |
HTx waiting period | ||
Duration until HTx in days, median (IQR) | 256 (275) | 179 (308) |
HU-listed, n (%) | 4 (23.5) | 2 (11.8) |
Delisted, n (%) | 5 (29.4) | 0 (0) |
Hospitalizations within one year | ||
Number of stays, mean (SD) | 3 (1.97) | 2.53 (2.12) |
Duration in days, mean (SD) | 32.24 (28.39) | 25.77 (25.17) |
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Tenge, T.; Roth, S.; M‘Pembele, R.; Lurati Buse, G.; Boenner, F.; Ballázs, C.; Tudorache, I.; Boeken, U.; Lichtenberg, A.; Neukirchen, M.; et al. Impact of Left Ventricular Assist Devices on Days Alive and Out of Hospital in Hemodynamically Stable Patients with End-Stage Heart Failure: A Propensity Score Matched Study. Life 2022, 12, 1966. https://doi.org/10.3390/life12121966
Tenge T, Roth S, M‘Pembele R, Lurati Buse G, Boenner F, Ballázs C, Tudorache I, Boeken U, Lichtenberg A, Neukirchen M, et al. Impact of Left Ventricular Assist Devices on Days Alive and Out of Hospital in Hemodynamically Stable Patients with End-Stage Heart Failure: A Propensity Score Matched Study. Life. 2022; 12(12):1966. https://doi.org/10.3390/life12121966
Chicago/Turabian StyleTenge, Theresa, Sebastian Roth, René M‘Pembele, Giovanna Lurati Buse, Florian Boenner, Christina Ballázs, Igor Tudorache, Udo Boeken, Artur Lichtenberg, Martin Neukirchen, and et al. 2022. "Impact of Left Ventricular Assist Devices on Days Alive and Out of Hospital in Hemodynamically Stable Patients with End-Stage Heart Failure: A Propensity Score Matched Study" Life 12, no. 12: 1966. https://doi.org/10.3390/life12121966