Relationship of Neural Correlates of Gait Characteristics and Cognitive Dysfunction in Patients with Mild Cognitive Impairment
Abstract
:1. Introduction
2. Methods
2.1. Participants
2.2. Clinical Assessment
2.3. Gait Assessment
2.4. MRI Acquisition
2.5. Gray Matter Volume and Curve Index Measurements
2.6. Statistical Analysis
3. Results
3.1. Demographics, Clinical Characteristics, and Gait Characteristics
3.2. Association between Gait Characteristics and Mild Cognitive Impairment
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Total (n = 80) | H-MMSE (n = 53) | L-MMSE (n = 27) | p Value | |
---|---|---|---|---|
Mean age | 74.6 ± 5.74 | 74.6 ± 5.33 | 74.6 ± 6.58 | 0.95 |
Gender, female (%) a | 58 (72.5) | 43 (81.1) | 15 (55.6) | 0.020 |
Year of education | 6.88 ± 3.980 | 5.94 ± 4.069 | 8.72 ± 3.114 | 0.003 |
Number of comorbidities | 3.7 ± 1.70 | 3.9 ± 1.61 | 3.1 ± 1.77 | 0.047 |
MMSE | 23.0 ± 3.70 | 24.2 ± 3.26 | 20.5 ± 3.26 | <0.0001 |
Depression scale | 4.9 ± 4.09 | 4.9 ± 4.24 | 5.1 ± 3.83 | 0.833 |
Anxiety scale | 6.8 ± 6.52 | 7.1 ± 6.87 | 6.3 ± 5.86 | 0.600 |
QOL scale | 34.4 ± 8.67 | 33.3 ± 8.39 | 36.5 ± 9.00 | 0.124 |
Stress scale | 1.57 ± 0.664 | 1.62 ± 0.716 | 1.49 ± 0.551 | 0.423 |
Height | 156.1 ± 8.11 | 155.4 ± 7.98 | 157.7 ± 8.30 | 0.232 |
Weight | 61.0 ± 10.92 | 61.9 ± 11.47 | 59.3 ± 9.72 | 0.324 |
BMI, mean (SD) | 25.0 ± 3.70 | 25.6 ± 3.84 | 23.8 ± 3.17 | 0.045 |
Waist circumference (cm) | 87.8 ± 10.12 | 87.6 ± 10.39 | 88.1 ± 9.75 | 0.825 |
Systolic BP (mmHg) | 128.6 ± 18.27 | 130.0 ± 18.44 | 126.0 ± 17.97 | 0.349 |
Diastolic BP (mmHg) | 77.0 ± 9.82 | 77.4 ± 9.41 | 76.1 ± 10.73 | 0.606 |
Fasting glucose (mg/dL) | 108.8 ± 26.28 | 111.3 ± 28.44 | 104.0 ± 21.08 | 0.240 |
Total cholesterol (mg/dL) | 162.4 ± 32.54 | 162.1 ± 34.00 | 163.0 ± 30.11 | 0.913 |
Total (n = 80) | H-MMSE (n = 53) | L-MMSE (n = 27) | p Value | |
---|---|---|---|---|
Gait velocity | 93.6 ± 20.16 | 93.9 ± 21.48 | 90.9 ± 17.35 | 0.404 |
Cadence | 107.1 ± 11.52 | 106.4 ± 12.02 | 108.3 ± 10.58 | 0.498 |
Step time (sec) | ||||
Left | 0.6 ± 0.07 | 0.6 ± 0.07 | 0.6 ± 0.06 | 0.575 |
Right | 0.6 ± 0.07 | 0.6 ± 0.07 | 0.6 ± 0.05 | 0.348 |
Step length (cm) | ||||
Left | 51.8 ± 8.52 | 52.9 ± 8.60 | 49.7 ± 8.09 | 0.111 |
Right | 52.3 ± 8.27 | 53.0 ± 8.15 | 50.9 ± 8.47 | 0.268 |
Cycle time (sec) | ||||
Left | 1.1 ± 0.13 | 1.1 ± 0.15 | 1.1 ± 0.11 | 0.418 |
Right | 1.1 ± 0.13 | 1.1 ± 0.15 | 1.1 ± 0.11 | 0.468 |
H-H base support (cm) | ||||
Left | 9.0 ± 3.12 | 8.5 ± 3.14 | 10.1 ± 2.82 | 0.027 |
Right | 8.8 ± 2.99 | 8.1 ± 2.78 | 10.2 ± 2.95 | 0.002 |
Swing % of cycle | ||||
Left | 36.8 ± 2.28 | 36.9 ± 2.23 | 36.7 ± 2.42 | 0.776 |
Right | 36.6 ± 2.45 | 36.9 ± 2.70 | 35.9 ± 1.75 | 0.085 |
Stance % of cycle | ||||
Left | 63.2 ± 2.28 | 63.1 ± 2.23 | 63.3 ± 2.42 | 0.795 |
Right | 63.4 ± 2.46 | 63.1 ± 2.70 | 64.1 ± 1.74 | 0.051 |
Double support % of cycle | ||||
Left | 26.4 ± 4.20 | 26.0 ± 4.41 | 27.2 ± 3.72 | 0.242 |
Right | 26.6 ± 4.41 | 26.2 ± 4.74 | 27.2 ± 3.67 | 0.354 |
Step time variability (%) | ||||
Left | 4.1 ± 2.77 | 4.1 ± 2.72 | 4.2 ± 2.91 | 0.849 |
Right | 3.7 ± 2.56 | 3.5 ± 2.76 | 4.1 ± 2.10 | 0.318 |
Step length variability (%) | ||||
Left | 2.4 ± 1.65 | 2.3 ± 1.45 | 2.6 ± 2.00 | 0.400 |
Right | 4.8 ± 3.45 | 4.4 ± 3.43 | 5.5 ± 3.45 | 0.169 |
Model 1 | Model 2 | Model 3 | ||||
---|---|---|---|---|---|---|
OR (95% CI) | p Value | OR (95% CI) | p Value | OR (95% CI) | p Value | |
Gait velocity | 0.990 (0.967, 1.013) | 0.400 | 0.968 (0.940, 0.998) | 0.035 | 0.957 (0.924, 0.991) | 0.015 |
Cadence | 1.015 (0.973, 1.057) | 0.493 | 1.008 (0.959, 1.059) | 0.763 | 1.011 (0.955, 1.069) | 0.712 |
Step time (sec) | ||||||
Left | 0.135 (0.000, 136.191) | 0.570 | 0.700 (0.000, 2222.031) | 0.931 | 0.896 (0.000, 8368.103) | 0.981 |
Right | 0.025 (0.000, 53.164) | 0.347 | 0.083 (0.000, 687.854) | 0.589 | 0.069 (0.000, 2747.780) | 0.621 |
Step length (cm) | ||||||
Left | 0.955 (0.901, 1.011) | 0.114 | 0.878 (0.805, 0.958) | 0.003 | 0.805 (0.711, 0.912) | 0.001 |
Right | 0.968 (0.913, 1.025) | 0.266 | 0.894 (0.822, 0.972) | 0.009 | 0.861 (0.781, 0.950) | 0.003 |
Cycle time (sec) | ||||||
Left | 0.213 (0.005, 8.789) | 0.415 | 0.504 (0.007, 38.928) | 0.757 | 0.567 (0.004, 83.640) | 0.824 |
Right | 0.252 (0.006, 10.106) | 0.464 | 0.475 (0.006, 37.650) | 0.739 | 0.496 (0.003, 75.879) | 0.785 |
H-H base support (cm) | ||||||
Left | 1.192 (1.015, 1.400) | 0.033 | 1.167 (0.978, 1.392) | 0.087 | 1.288 (1.047, 1.584) | 0.017 |
Right | 1.292 (1.083, 1.542) | 0.004 | 1.266 (1.040, 1.541) | 0.019 | 1.391 (1.108, 1.746) | 0.005 |
Swing % of cycle | ||||||
Left | 0.971 (0.792, 1.189) | 0.773 | 0.864 (0.684, 1.091) | 0.218 | 0.724 (0.541, 0.967) | 0.029 |
Right | 0.844 (0.694, 1.027) | 0.090 | 0.716 (0.560, 0.916) | 0.008 | 0.539 (0.378, 0.768) | 0.001 |
Stance % of cycle | ||||||
Left | 1.028 (0.839, 1.260) | 0.792 | 1.154 (0.913, 1.458) | 0.230 | 1.377 (1.031, 1.839) | 0.030 |
Right | 1.183 (0.973, 1.439) | 0.092 | 1.392 (1.089, 1.779) | 0.008 | 1.845 (1.298, 2.621) | 0.001 |
Double support % of cycle | ||||||
Left | 1.069 (0.956, 1.194) | 0.242 | 1.161 (1.014, 1.329) | 0.030 | 1.357 (1.155, 1.641) | 0.002 |
Right | 1.051 (0.946, 1.167) | 0.352 | 1.149 (1.009, 1.308) | 0.036 | 1.354 (1.130, 1.623) | 0.001 |
Step time variability | ||||||
Left | 1.017 (0.860, 1.201) | 0.847 | 1.022 (0.854, 1.222) | 0.815 | 1.045 (0.844, 1.295) | 0.684 |
Right | 1.095 (0.915, 1.311) | 0.320 | 1.147 (0.942, 1.397) | 0.173 | 1.188 (0.963, 1.465) | 0.109 |
Step length variability | ||||||
Left | 1.143 (0.865, 1.512) | 0.347 | 1.178 (0.863, 1.609) | 0.302 | 1.166 (0.845, 1.609) | 0.350 |
Right | 1.098 (0.961, 1.255) | 0.170 | 1.149 (0.986, 1.339) | 0.076 | 1.215 (1.027, 1.436) | 0.023 |
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Kim, Y.J.; Park, I.; Choi, H.-C.; Ahn, M.-E.; Ryu, O.-H.; Jang, D.; Lee, U.; Lee, S.-K. Relationship of Neural Correlates of Gait Characteristics and Cognitive Dysfunction in Patients with Mild Cognitive Impairment. J. Clin. Med. 2023, 12, 5347. https://doi.org/10.3390/jcm12165347
Kim YJ, Park I, Choi H-C, Ahn M-E, Ryu O-H, Jang D, Lee U, Lee S-K. Relationship of Neural Correlates of Gait Characteristics and Cognitive Dysfunction in Patients with Mild Cognitive Impairment. Journal of Clinical Medicine. 2023; 12(16):5347. https://doi.org/10.3390/jcm12165347
Chicago/Turabian StyleKim, Yeo Jin, Ingyu Park, Hui-Chul Choi, Moo-Eob Ahn, Ohk-Hyun Ryu, Daehun Jang, Unjoo Lee, and Sang-Kyu Lee. 2023. "Relationship of Neural Correlates of Gait Characteristics and Cognitive Dysfunction in Patients with Mild Cognitive Impairment" Journal of Clinical Medicine 12, no. 16: 5347. https://doi.org/10.3390/jcm12165347