Determinants of Renal Micro-Perfusion as Assessed with Contrast-Enhanced Ultrasound in Healthy Males and Females
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Study Design and Settings
2.3. Laboratory
2.4. Renal Ultrasound Parameters
2.5. Statistics
3. Results
3.1. Participants and Baseline Characteristics
3.2. Doppler US and CEUS Parameters
3.3. Associations between CEUS Indices and Clinical and Laboratory Variables
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Parameter | Total n = 115 | Males n = 38 | Females n = 77 | p |
---|---|---|---|---|
Age (years) | 37 ± 12 | 37 ± 13 | 37 ± 12 | 0.81 |
BMI (kg/m2) | 24.1 ± 3.4 | 24.6 ± 3.4 | 23.8 ± 3.3 | 0.26 |
SBP (mmHg) | 117 ± 11 | 124 ± 7 | 113 ± 10 | 0.00 |
DBP (mmHg) | 71 ± 8 | 72 ± 9 | 70 ± 7 | 0.34 |
MBP (mmHg) | 86 ± 8 | 89 ± 7 | 84 ± 7 | 0.00 |
HR (bpm) | 66 ± 10 | 61 ± 10 | 68 ± 9 | 0.00 |
Creatinine (µmol/L) | 72 ± 11 | 82 ± 10 | 67 ± 9 | 0.00 |
eGFR (mL/min/1.73 m2) | 101 ± 17 | 91 ± 17 | 106 ± 15 | 0.00 |
Sodium (mmol/L) | 140 ± 2 | 141 ± 1 | 140 ± 2 | 0.11 |
Potassium (mmol/L) | 3.81 ± 0.27 | 3.89 ± 0.25 | 3.77 ± 0.27 | 0.03 |
Uric acid (mmol/L) | 279 ± 119 | 321 ± 56 | 259 ± 135 | 0.01 |
Bicarbonate (mmol/L) | 23 ± 2 | 24 ± 2 | 23 ± 1 | 0.00 |
PRA (ng/mL/h) | 0.77 (0.33–1.19) | 0.40 (0.15–0.87) | 0.93(0.54–1.27) | 0.001 |
PAC (pmol/L) | 127 (69–222) | 81 (34–149) | 164 (94–278) | 0.0002 |
Parameters | Males n = 38 | Females n = 77 | p |
---|---|---|---|
PI (a.u) | 1965 (1294–3346) | 2705 (1641–3777) | 0.02 |
rBV (a.u.) | 4149 (2386–6562) | 4895 (3330–7020) | 0.21 |
mTT (s) | 2.15 (1.7–2.7) | 1.85 (1.53–2.34) | 0.09 |
RRI (a.u.) | 0.60 (0.56–0.64) | 0.63 (0.60–0.66) | 0.0003 |
Kidney Volume (mL) | 129 (97–159) | 109 (94–129) | 0.04 |
Parameter | Follicular n = 15 | Luteal n = 11 | p |
---|---|---|---|
PI (a.u.) | 2857 (1445–4748) | 2571 (2224–3604) | 0.83 |
rBV | 4895 (2872–7010) | 4982 (3322–5800) | 0.92 |
mTT (s) | 1.68 (1.53–2.09) | 1.81 (1.50–2.34) | 0.84 |
RRI | 0.61 (0.60–0.66) | 0.64 (0.62–0.65) | 0.31 |
Clinical Variables | Fully Adjusted β (95% CI) | p |
---|---|---|
Sex (Female vs. Male) | 0.065 (−0.33 to 0.46) | 0.74 |
eGFR (mL/min/1.73 m2) | 0.002 (−0.008 to 0.011) | 0.69 |
SBP (mmHg) | −0.007 (−0.02 to 0.10) | 0.43 |
HR (bpm) | 0.005 (−0.011 to 0.02) | 0.55 |
Potassium (mmol/L) | −0.22 (−0.74 to 0.30) | 0.40 |
Bicarbonates (mmol/L) | −0.05 (−0.15 to 0.05) | 0.35 |
PRA-Log (ng/mL/h) | 0.17 (0.01 to 0.33) | 0.04 |
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Ulpiano Trillig, A.; Damianaki, A.; Hendriks-Balk, M.; Brito, W.; Garessus, J.; Burnier, M.; Wuerzner, G.; Pruijm, M. Determinants of Renal Micro-Perfusion as Assessed with Contrast-Enhanced Ultrasound in Healthy Males and Females. J. Clin. Med. 2023, 12, 4141. https://doi.org/10.3390/jcm12124141
Ulpiano Trillig A, Damianaki A, Hendriks-Balk M, Brito W, Garessus J, Burnier M, Wuerzner G, Pruijm M. Determinants of Renal Micro-Perfusion as Assessed with Contrast-Enhanced Ultrasound in Healthy Males and Females. Journal of Clinical Medicine. 2023; 12(12):4141. https://doi.org/10.3390/jcm12124141
Chicago/Turabian StyleUlpiano Trillig, Antonio, Aikaterini Damianaki, Mariëlle Hendriks-Balk, Wendy Brito, Jonas Garessus, Michel Burnier, Grégoire Wuerzner, and Menno Pruijm. 2023. "Determinants of Renal Micro-Perfusion as Assessed with Contrast-Enhanced Ultrasound in Healthy Males and Females" Journal of Clinical Medicine 12, no. 12: 4141. https://doi.org/10.3390/jcm12124141