Multi-Wavelength Photobiomodulation Ameliorates Sodium Iodate-Induced Age-Related Macular Degeneration in Rats
Abstract
:1. Introduction
2. Results
2.1. Multi-Wavelength PBM Does Not Damage RPE Cells In Vitro
2.2. In Vivo Rat Model of Sodium Iodate-Induced AMD
2.3. Multi-Wavelength PBM Protects against Retinal Degeneration
2.4. Multi-Wavelength PBM Reduces NaIO3-Induced Retinal Apoptosis
2.5. Multi-Wavelength PBM Prevents Depletion of Rod Bipolar Cells in the Inner Nerve Layer
2.6. Multi-Wavelength PBM Inhibits Photoreceptor Degeneration and Reduces RPE Toxicity
3. Discussion
4. Materials and Methods
4.1. Cell Culture
4.2. Multi-Wavelength PBM
4.3. Cell Viability and Proliferation
4.4. In Vivo Experimental Schedule
4.5. Histology
4.6. TUNEL Assay
4.7. Immunohistochemistry
4.8. Statistics
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Goo, H.; Lee, M.Y.; Lee, Y.-J.; Lee, S.; Ahn, J.-C.; Hong, N. Multi-Wavelength Photobiomodulation Ameliorates Sodium Iodate-Induced Age-Related Macular Degeneration in Rats. Int. J. Mol. Sci. 2023, 24, 17394. https://doi.org/10.3390/ijms242417394
Goo H, Lee MY, Lee Y-J, Lee S, Ahn J-C, Hong N. Multi-Wavelength Photobiomodulation Ameliorates Sodium Iodate-Induced Age-Related Macular Degeneration in Rats. International Journal of Molecular Sciences. 2023; 24(24):17394. https://doi.org/10.3390/ijms242417394
Chicago/Turabian StyleGoo, Hyeyoon, Min Young Lee, Yea-Jin Lee, Sangkeun Lee, Jin-Chul Ahn, and Namgue Hong. 2023. "Multi-Wavelength Photobiomodulation Ameliorates Sodium Iodate-Induced Age-Related Macular Degeneration in Rats" International Journal of Molecular Sciences 24, no. 24: 17394. https://doi.org/10.3390/ijms242417394