Metal Complexes with Schiff Bases: Data Collection and Recent Studies on Biological Activities
Abstract
:1. Introduction
2. Mononuclear SBs Complexes
2.1. Mononuclear SBs Complexes with Antibacterial and Antiproliferative Activities
Structure | Compound | Antimicrobial Activity (MIC or IZD) | IC50 | Ref |
---|---|---|---|---|
[CuL]Cl2 (1) | MIC = 5.6 µM (S. aureus) MIC = 5.8 µM (B. subtilis) MIC = 5.4 µM (E. coli) MIC = 6.2 µM (K. pneumoniae) MIC = 5.8 µM (S. typhi) MIC = 5.8 µM (A. niger) MIC = 5.6 µM (F. solani) MIC = 5.2 µM (A. flavus) MIC = 6.4 µM (R. bataticola) MIC = 6.2 µM (C. albicans) | IC50 = 14 ± 0.8 µM (HeLa) IC50 = 16 ± 1.0 µM (MCF-7) IC50 = 16 ± 1.0 µM (Hep-2) IC50 = 86 ± 1.0 µM (NHDF) | Rajakkani et al., 2021 [60] | |
HNPPd (2) | MIC = 3.25 µM; IZD = 28 ± 0.13 mm (S. marcescens) MIC = 3.75 µM; IZD = 22.5 ± 0.09 mm (E. coli) MIC = 3.00 µM; IZD = 38.5 ± 0.12 mm (M. luteus) IZD = 19 ± 0.09 mm (A. flavus) IZD = 35.0 ± 0.08 mm (G. candidum) IZD = 22.5 ± 0.14 mm (F. oxysporum) | IC50 = 6.75 ± 0.08 (HCT-116) IC50 = 17.85 ± 0.10 (MCF-7) IC50 = 13.10 ± 0.15 (HepG-2) | Abu-Dief et al., 2021 [61] | |
ZnL2 (3) | IZD = 13 mm (E. coli PTCC1394) IZD = 15 mm (P. aeruginosa PTCC1074) IZD = 29 mm (S. aureus PTCC1431) IZD = 26 mm (B. cereus PTCC1015) | - | Kargar et al., 2021 [62] | |
NiL3 (4) | IZD = 13 mm (E. coli PTCC1394) IZD = 15 mm (P. aeruginosa PTCC1074) IZD = 29 mm (S. aureus PTCC1431) IZD = 26 mm (B. cereus PTCC1015) | - | Kargar et al., 2021 [62] | |
CuL3 (5) | IZD = 16 mm (E. coli PTCC1394) IZD = 14 mm (P. aeruginosa PTCC1074) IZD = 23 mm (S. aureus PTCC1431) IZD = 26 mm (B. cereus PTCC1015) | - | Kargar et al., 2021 [62] | |
NilUns (6) | IZD = 15 mm (E. coli PTCC1394) IZD = 14 mm (P. aeruginosa PTCC1074) IZD = 25 mm (S. aureus PTCC1431) IZD = 21 mm (B. cereus PTCC1015) | - | Kargar et al., 2021 [63] | |
Z2Zn (7) | IZD = 15 mm (M. luteus ATCC 934) IZD = 21 mm (S. aureus ATCC 29213) | IC50 = 25.2 µg/mL (MCF-7) IC50 = 81.2 µg/mL (A549) IC50 = 68.7 µg/mL (HDF) | Al-Shboul et al., 2022 [64] | |
Z3Zn (8) | IZD = 25 mm (M. luteus ATCC 934) IZD = 18 mm (S. aureus ATCC 29213) | IC50 = 17.7 µg/mL (MCF-7) IC50 = 199.4 µg/mL (A549) IC50 = 27.6 µg/mL (HDF) | Al-Shboul et al., 2022 [64] | |
Z4Zn (9) | IZD = 15 mm (M. luteus ATCC 934) IZD = 25 mm (S. aureus ATCC 29213) | IC50 = 14.1 µg/mL (MCF-7) IC50 = 25.2 µg/mL (A549) IC50 = 28.3 µg/mL (HDF) | Al-Shboul et al., 2022 [64] | |
Z1Cu (10) | IZD = 10 mm (E. coli ATCC25922) | IC50 = 10.4 µg/mL (MCF-7) IC50 = 43.7 µg/mL (A549) IC50 = 8.5 µg/mL (HDF) | Al-Shboul et al., 2022 [64] | |
Z3Cu (11) | IZD = 20 mm (E. coli ATCC25922) | IC50 = 172.0 µg/mL (MCF-7) IC50 = 130.0 µg/mL (A549) IC50 = 92.0 µg/mL (HDF) | Al-Shboul et al., 2022 [64] | |
Z2Cu (12) | - | IC50 = 1.9 µg/mL (MCF-7) IC50 = 4.0 µg/mL (A549) IC50 = 1.5 µg/mL (HDF) | Al-Shboul et al., 2022 [64] | |
Ni(L2) (13) | MIC = 256 µg/mL (P. aeruginosa 15) MIC = 50.8→16 μg/mL (gentamicin S. aureus) MIC = 32→25.4 μg/mL (gentamicin E. coli) MIC = 203.2→128 μg/mL (amikacin E. coli) | IC50 = 1.076 ± 0.04039 μg/mL after 72 h (L. amazonensis) | Maia et al., 2022 [66] | |
Cd(H2L) (14) | IZD = 11 mm (P. aeruginosa ATCC 27853, 200 μg/disk) IZD = 11 mm (E. faecalis ATCC 23212, 200 μg/disk) IZD = 11 mm (S. epidermidis ATCC 34384, 200 μg/disk) | - | Tyula et al., 2023 [67] | |
Hg(H2L) (15) | IZD = 13 mm (P. aeruginosa ATCC 27853, 200 μg/disk) IZD = 20 mm (E. faecalis ATCC 23212, 200 μg/disk) IZD = 17 mm (S. epidermidis ATCC 34384, 200 μg/disk) | - | Tyula et al., 2023 [67] | |
[Zn(HMHC)2]H2O (16) | IZD = 23 mm (B. subtilis) IZD = 23 mm (K. pneumoniae) IZD = 15 mm (C. albicans) IZD = 17 mm (A. niger) Percentage inhibition = 92.2% (Protein denaturation) | - | Saritha et al., 2021 [68] | |
17 | - | IC50 = 1.6 ± 0.1 µM (MCF-7) IC50 = 9.6 ± 0.1 µM (A549) | Gowdhami et al., 2022 [72] | |
18 | - | IC50 = 2.9 ± 0.2 µM (MCF-7) IC50 = 9.1 ± 0.1 µM (A549) | Gowdhami et al., 2022 [72] | |
[PdLCl]·H2O (19) | - | IC50 = 3.4 × 10–6 μg/mL (EAC) | Hassona et al., 2022 [73] |
2.2. Mononuclear SBs Complexes with Antimalarial, Antioxidant, Antidiabetic, and Anti-Alzheimer Activities
3. Binuclear SBs Complexes
4. Summary
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Structure | Compound | % Inhibition, MIC, and IC50 | Ki | Ref |
---|---|---|---|---|
Zn(BZ-PCBPMP)2 (20) | MIC = 0.56 μmol/L (P. falciparum) | - | Shaikh et al., 2022 [74] | |
Fe(III) complex (21) | % inhib: 65.54% (antimalarial) % inhib: 52–54% (α-amylase) % inhib: 94.27% (DPPH) | - | Ragole et al., 2022 [75] | |
22 | IC50 = 12.45 µM (AChE) IC50 = 9.61 µM (BChE) IC50 = 35.57 µM (α-glycosidase) | Ki = 11.92 ± 3.90 µM (AChE) Ki = 6.98 ± 0.96 µM (BChE) Ki = 38.17 ± 6.26 µM (α-glycosidase) | Şenocak et al., 2021 [76] | |
23 | IC50 = 7.24 µM (AChE) IC50 = 4.73 µM (BChE) IC50 = 30.84 µM (α-glycosidase) | Ki = 6.26 ± 0.83 µM (AChE) Ki = 3.68 ± 0.54 µM (BChE) Ki = 37.14 ± 7.12 µM (α-glycosidase) | Şenocak et al., 2021 [76] | |
24 | IC50 = 18.06 µM (AChE) IC50 = 11.25 µM (BChE) IC50 = 26.21 µM (α-glycosidase) | Ki = 15.73 ± 4.73 µM (AChE) Ki = 10.27 ± 1.68 µM (BChE) Ki = 30.50 ± 3.82 µM (α-glycosidase) | Şenocak et al., 2021 [76] | |
25 | IC50 = 1.41 ± 0.03 μmol/mL (α-amylase) IC50 = 0.62 ± 0.07 μmol/mL (α-glucosidase) | - | Deswal et al., 2022 [78] | |
26 | IC50 = 1.33 ± 0.05 μmol/mL (α-amylase) IC50 = 0.60 ± 0.05 μmol/mL (α-glucosidase) | - | Deswal et al., 2022 [78] |
Structure | Compound | Antimicrobial and Antioxidant Activities | IC50 | Ref |
---|---|---|---|---|
CuL1 (27) | - | IC50 = 9.48 ± 0.24 µM (MCF-7) IC50 = 10.15 ± 0.6 µM (A549) | Keypour et al., 2021 [89] | |
NiL1 (28) | - | IC50 = 12.16 ± 0.79 µM (MCF-7) IC50 = 13.63 ± 0.91 µM (A549) | Keypour et al., 2021 [89] | |
Bi2(HL)2(NO3)4 (29) | - | IC50 = 3.93 × 10−4 mol/L (S. pombe) | Lei et al., 2022 [90] | |
(30) | MIC = 2 μg/mL and 1.38 μM (S. aureus Newman) | IC50 = 0.23 ± 0.09 μM (SNU-16) | Li et al., 2022 [91] | |
Z1 (31) | IZD = 16 mm (S. aureus PTCC1431) IZD = 15 mm (B. cereus PTCC1015) | - | Kargar et al., 2022 [85] | |
Z2 (32) | IZD = 11 mm (S. aureus PTCC1431) IZD = 11 mm (B. cereus PTCC1015) | - | Kargar et al., 2022 [85] | |
33 | CFU/mL = 2.2 × 105 (E. coli ATCC 25922); Antibacterial rate = 85% CFU/mL = 6.0 × 105 (S. aureus ATCC 6538); Antibacterial rate = 88% | IC50 = 103 μM (MCF-7) | Goudarzi et al., 2022 [92] | |
34 | CFU/mL = 1.8 × 105 (E. coli ATCC 25922); Antibacterial rate = 85% CFU/mL = 5.1 × 105 (S. aureus ATCC 6538); Antibacterial rate = 66% | IC50 = 89 μM (MCF-7) | Goudarzi et al., 2022 [92] | |
Cu-Gd complex (35) | - | IC50 = 36.09 ± 4.11 µM (MCF-7) IC50 = 15.66 ± 2.92 (HeLa) IC50 = 20.23 ± 4.77 (LNCaP) IC50 = 96.62 ± 3.11 (normal fibroblasts) | Keshavarzian et al., 2022 [93] | |
Cu(II) complex (36) | Scavenging inhibition (%) = 40.92% (DPPH) scavenging inhibition (%) = 87.12% (ABTS) | IC50 = 31.88 μM (Caco-2) IC50 = 285 μM (L-929) | Savcı et al., 2022 [94] | |
Pd(II) complex (37) | Scavenging inhibition (%) = 80.48% (DPPH) scavenging inhibition (%) = 43.15% (ABTS) | IC50 = 25.35 μM (Caco-2) IC50 = 114.28 μM (L-929) | Savcı et al., 2022 [94] | |
CuII2L(μ1,1-NO3)(μ-OH)(NO3)(H2O) (38) | - | IC50 = 49.92 ± 4.90 µmol/L (MCF-7) IC50 = 21.53 ± 2.72 µmol/L (HeLa) IC50 = 29.32 ± 5.42 µmol/L (LNCaP) IC50 = 73.03 ± 4.16 µmol/L (Normal Skin Fibroblasts) | Jahromi et al., 2022 [95] |
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Sinicropi, M.S.; Ceramella, J.; Iacopetta, D.; Catalano, A.; Mariconda, A.; Rosano, C.; Saturnino, C.; El-Kashef, H.; Longo, P. Metal Complexes with Schiff Bases: Data Collection and Recent Studies on Biological Activities. Int. J. Mol. Sci. 2022, 23, 14840. https://doi.org/10.3390/ijms232314840
Sinicropi MS, Ceramella J, Iacopetta D, Catalano A, Mariconda A, Rosano C, Saturnino C, El-Kashef H, Longo P. Metal Complexes with Schiff Bases: Data Collection and Recent Studies on Biological Activities. International Journal of Molecular Sciences. 2022; 23(23):14840. https://doi.org/10.3390/ijms232314840
Chicago/Turabian StyleSinicropi, Maria Stefania, Jessica Ceramella, Domenico Iacopetta, Alessia Catalano, Annaluisa Mariconda, Camillo Rosano, Carmela Saturnino, Hussein El-Kashef, and Pasquale Longo. 2022. "Metal Complexes with Schiff Bases: Data Collection and Recent Studies on Biological Activities" International Journal of Molecular Sciences 23, no. 23: 14840. https://doi.org/10.3390/ijms232314840