Ovarian Morphology in Non-Hirsute, Normo-Androgenic, Eumenorrheic Premenopausal Women from a Multi-Ethnic Unselected Siberian Population
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Total N = 408 | Caucasians N = 285 | Asians N = 123 | p-Value | |
---|---|---|---|---|
n = 563 * | n = 388 * | n = 175 * | ||
OV | ||||
Mean ± SD | 6.30 ± 2.31 | 6.58 ± 2.36 | 5.69 ± 2.09 | pU < 0.001 |
(Min–Max) | (0.54; 16.98) | (0.54; 16.98) | (1.57; 14.63) | |
Median | 6.01 | 6.305 | 6.00 | |
(Lower Q; Upper Q) | (4.77; 7.37) | (5.04; 7.78) | (4.34; 6.63) | |
95 Percentile (95% CI) | 10.31 (9.86; 11.22) | 10.63 (10.01; 11.88) | 9.32 (8.57; 10.65) | |
97.5 Percentile (95% CI) | 12.3 (10.68; 13.16) | 12.45 (11.09; 13.30) | 10.62 (9.34; 13.92) | |
98 Percentile (95% CI) | 12.56 (11.28; 13.56) | 12.58 (11.39; 13.76) | 10.66 (9.51; 14.29) | |
FNPO | ||||
Mean ± SD | 6.85 ± 2.78 | 7.19 ± 3.00 | 6.11 ± 2.03 | pU < 0.001 |
(Min–Max) | (1.00; 30.00) | (1.00; 30.00) | (1.00; 14.00) | |
Median | 6.00 | 7.00 | 6.00 | |
(Lower Q; Upper Q) | (5.00; 8.00) | (5.00; 8.00) | (5.00; 6.00) | |
95 Percentile (95% CI) | 12 (10.00; 10.72) | 12 (10; 12) | 10 (9; 10) # | |
97.5 Percentile (95% CI) | 14 (12.00; 14.95) | 14 (12; 14) | 10 (9; 10) # | |
98 Percentile (95% CI) | 14 (12.00; 14.00) | 15 (13.25; 15.26) | 10.52 (10; 12) # |
Total N = 408 | Caucasians N = 285 | Asians N = 123 | ||||
---|---|---|---|---|---|---|
<35 yrs n = 269 * | ≥35 yrs n = 294 * | <35 yrs n = 194 * | ≥35 yrs n = 194 * | <35 yrs n = 75 * | ≥35 yrs n = 100 * | |
Ovarian volume | ||||||
Mean ± SD | 6.72 ± 2.37 | 5.91 ± 2.2 ** | 7.09 ± 2.38 | 6.07 ± 2.22 ** | 5.78 ± 2.07 | 5.62 ± 2.12 |
(Min–Max) | (0.54; 16.98) | (0.94; 14.63) | (0.54; 16.98) | (0.94; 13.56) | (1.57; 12.72) | (2.2; 14.63) |
Median | 6.28 | 5.62 | 6.7 | 5.93 | 5.22 | 5.4 |
(Lower Q; Upper Q) | (5.08; 7.85) | (4.39; 7.11) | (5.5; 8.09) | (4.6; 7.27) | (4.44; 6.96) | (4.17; 6.46) |
95 Percentile | 11.32 | 9.83 | 12.05 | 9.85 | 9.55 | 9.18 |
(95% CI) | (10.13; 12.65) | (9.32; 10.32) | (10.53; 12.89) | (9.49; 10.26) | (8.43; 11.26) | (7.96; 10.88) |
97.5 Percentile | 12.67 | 10.47 | 12.81 | 10.24 | 10.2 | 10.64 |
(95% CI) | (11.38; 13.81) | (9.85; 12.56) | (11.6; 14.18) | (9.85; 12.56) | (9.11; 12.72) | (8.59;14.63) |
98 Percentile | 12.73 | 10.6 | 13.26 | 10.35 | 10.39 | 10.74 |
(95% CI) | (11.91; 15.15) | (9.94; 13.56) | (12.33; 15.9) | (9.87; 12.56) | (9.22; 12.72) | (9.02; 14.63) |
Follicle number per ovary (FNPO) | ||||||
Mean ± SD | 7.88 ± 2.9 | 5.91 ± 2.29 ** | 8.22 ± 3.14 | 6.15 ± 2.47 ** | 7.03 ± 1.94 | 5.43 ± 1.83 ** |
(Min–Max) | (3; 30) | (1; 15) | (3; 30) | (1; 15) | (3; 14) | (1; 12) |
Median | 7 | 6 | 7 | 6 | 7 | 5 |
(Lower Q; Upper Q) | (6; 9) | (5; 7) | (6; 9) | (5; 7) | (6; 8) | (4; 6) |
95 Percentile | 13 | 10.35 | 12 | 10 | 8.05 | |
(95% CI) | (12.0;14.6) | (9.0; 12.0) | 14 (13.0; 16.0) | (11.65; 14.65) | (8.0; 11.0) | (8.0; 10.05) |
97.5 Percentile | 15 | 12 | 15 | 12.17 | 10.3 | 9.52 |
(95% CI) | (13.0; 16.0) | (11.0; 13.32) | (12.83; 16.0) | (12.0; 14.0) | (10.0; 14.0) | (8.0; 11.52) |
98 Percentile | 15 | 12 # | 15.4 | 13 # | 11.04 | 10.02 |
(95% CI) | (13.0; 16.0) | (10.0; 12.0) | (14.0; 18.0) | (12.0; 14.0) | (10.0; 14.0) | (8.02; 12.0) |
Author, Year, Country | Setting Study Design # | Total Population | Ethnicity Controls | Age Range | OV, Mean ± StD. (Min–Max) For Controls | OV, UNLs Controls | FNPO Mean ± SD. (Min–Max) For Controls | FPNO, UNLs Controls | Transducer Frequency |
---|---|---|---|---|---|---|---|---|---|
Ahmad et al., 2019, USA [20]. | Cross-sectional study | Control: 756 (FNPO, OV) PCOS: 245 (FNPO), 297 (OV) | Caucasians | Overall (20–40) | 6.49 ± 4.98 | 6.75 | 10.01 ± 5.29 | 13 | 4–8 MHz 4–10 MHz |
25 to <30 | 7.31 ± 6.33 | 8.5 | 12.38 ± 5.52 | 15 | |||||
30 to <35 | 6.49 ± 4.97 | 7.00 | 10.14 ± 4.8 | 14 | |||||
35 to <40 | 5.82 ± 3.39 | 6.25 | 7.96 ± 4.66 | 12 | |||||
Carmina et al., 2016, Italy [21]. | Retrospective matched controlled study | PCOS: 113 Control: 47 | Caucasians | 19 to 35 years | N/A | 4.4 ± 1.8 | N/A | 10 ± 4 | 8–10 MHz |
Chen et al., 2008, China [22]. | Age-matched women | PCOS: 432 Control: 153 | Chinese population | N/A | N/A | 6.4 | N/A | 10 | 6 MHz |
Dewailly et al., 2014, France [23]. | Retrospective study | Control: 521 PCOS: 272 OA + HA (full-blown): 95 OA + PCOM: 110 HA + PCOM: 67 | Caucasians | 18 to 40 years | N/A | N/A | N/A | 12.0 | 5–7 MHz |
Fulghesu et al., 2001, Italy [24]. | Retrospective data analysis | Control: 30 Multi-follicular Ovaries (MFO): 27 PCOS: 53 | Caucasians | 18–38 | N/A | 13.21 | N/A | N/A | 6.5 MHz |
Jonard et al., 2005, France [25]. | Observational cohort study | Control: 57 PCOS: 98 | Caucasians | Control: 29.0 (24.5–35.0) PCOS: 27.2 (19.5–33.0) | 4.75 (3.11–6.86) | 7 | 6.5 (4.5–10.5) | 12.0 | 7 MHz |
Sujata and Swoyam, 2018, India [26]. | Not provided | PCOS: 86 Control: 45 | Caucasians | 18–45 years | 5.06 ± 2.44 | 6.15 | 7.13 ± 3.51 | 12.0 | 6–12 MHz |
Kim et al., 2017, United States/Iceland [27]. | Cross-sectional, case-control design | Control: 666 (Boston) and 32 (Iceland) PCOS: 544 (Boston) and 105 (Iceland) 18 to >44 years | Caucasians | ≤24 years | N/A | 12 | N/A | 13 | 4–8 MHz |
25–29 years | N/A | 10 | N/A | 14 | |||||
30–34 years | N/A | 9 | N/A | 10 | |||||
35–39 years | N/A | 8 | N/A | 10 | |||||
40–44 years | N/A | 10 | N/A | 9 | |||||
Köşüş et al., 2011, Turkey [5]. | Prospective study | Control: 65 PCOS: 251 | Caucasians | N/A | 6.43 | N/A | 8 | 6.5 MHz | |
Le et al., 2021, Vietnam [28]. | Cross-sectional study | Control: 273 PCOS: 119 | Asians | 33.99 ± 4.78 years | 6.08 ± 3.67 | 6.0 | N/A | N/A | 7 MHz |
Lie Fong et al., 2017, Netherlands/United States [29]. | Retrospective observational cohort study | Control: 297 Young non-PCOM (Cluster 1): 118 Young PCOM (Cluster 2): 28 Old non-PCOM (Cluster 3): 100 Old PCOM (Cluster 4): 51 PCOS: 700 | Caucasians | Young women | N/A | N/A | 9 (5–24) | 12.25 | 6.5–8 MHz |
Old women | N/A | N/A | 10.75 | ||||||
Lujan et al. 2013, United States/Canada [30]. | A diagnostic test study was performed using cross-sectional data | Control: 70 PCOS: 98 | Caucasians | 18–44 years | N/A | 10 | N/A | 26 | 5–9 MHz 6–12 MHz |
Wongwananuruk et al., 2018, Thailand [31]. | Cross-sectional study | Control: 63 PCOS: 55 | Asians | 18–45 years of age | 4.66 ± 1.83 | 6.5 | 9.97 ± 3.86 | 15 | 8 MHz |
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Lazareva, L.; Suturina, L.; Atalyan, A.; Danusevich, I.; Nadelyaeva, I.; Belenkaya, L.; Egorova, I.; Ievleva, K.; Babaeva, N.; Lizneva, D.; et al. Ovarian Morphology in Non-Hirsute, Normo-Androgenic, Eumenorrheic Premenopausal Women from a Multi-Ethnic Unselected Siberian Population. Diagnostics 2024, 14, 673. https://doi.org/10.3390/diagnostics14070673
Lazareva L, Suturina L, Atalyan A, Danusevich I, Nadelyaeva I, Belenkaya L, Egorova I, Ievleva K, Babaeva N, Lizneva D, et al. Ovarian Morphology in Non-Hirsute, Normo-Androgenic, Eumenorrheic Premenopausal Women from a Multi-Ethnic Unselected Siberian Population. Diagnostics. 2024; 14(7):673. https://doi.org/10.3390/diagnostics14070673
Chicago/Turabian StyleLazareva, Ludmila, Larisa Suturina, Alina Atalyan, Irina Danusevich, Iana Nadelyaeva, Lilia Belenkaya, Irina Egorova, Kseniia Ievleva, Natalia Babaeva, Daria Lizneva, and et al. 2024. "Ovarian Morphology in Non-Hirsute, Normo-Androgenic, Eumenorrheic Premenopausal Women from a Multi-Ethnic Unselected Siberian Population" Diagnostics 14, no. 7: 673. https://doi.org/10.3390/diagnostics14070673