Oxidative Stress Biomarkers and Early Brain Activity in Extremely Preterm Infants: A Prospective Cohort Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Biomarkers
2.3. Clinical Data Collection
2.4. AEEG Acquisition
2.5. EEG Post-Registration Analysis
2.6. Statistical Analysis
3. Results
3.1. Cord Blood Isoprostanes and Early Brain Activity
3.2. Isoprostanes at 24–48 h of Life and Early Brain Activity
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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n = 39 | |
---|---|
Gestational age (weeks); mean (SD) | 26.2 (1) |
Birth weight (g); mean (SD) | 859 (66) |
Birth weight < 10th percentile; n (%) | 2 (5) |
Male; n (%) | 17 (43) |
Caesarean section; n (%) | 18 (46) |
Apgar score at 5 min; median (IQR) | 8 (6–8) |
Mechanical ventilation (days); median (IQR) | 5 (2–16) |
BPD; n (%) | 5 (13) |
PDA; n (%) Pharmacological treated Surgical closure | 22 (56) 2 (5) |
Sepsis; n (%) | 7 (18) |
NEC; n (%) Conservatively treated Surgery | 1 (2) 3 (7) |
IVH; n (%) 1–2 grade 3–4 grade | 11 (28) 0 (0) |
FiO2 between 24 and 48 h after birth; mean (SD) | 24 (4) |
WMI mild or moderate; n (%) | 27 (69) |
Cord blood isoprostanes (pg/mL); median (IQR) | 59.3 (44.4–89.1) |
Plasma isoprostanes between 24–48 h (pg/mL); median (IQR) | 52.0 (33.2–82.2) |
Univariate Regression Analyses | |||||||||
---|---|---|---|---|---|---|---|---|---|
ISI R = 0.26 | SAT RATE R = 0.04 | Pct Time Under 5 R = 0.10 | |||||||
B | 95% CI | p | B | 95% CI | p | B | 95% CI | p | |
cb-IPs | −0.004 | −0.013–0.005 | 0.344 | 0.001 | −0.011–0.13 | 0.872 | −0.025 | −0.172–0.122 | 0.721 |
Multivariate Regression Analyses | |||||||||
ISI R = 0.70 | SAT RATE R = 0.45 | Pct Time Under 5 R = 0.67 | |||||||
B | 95% CI | p | B | 95% CI | p | B | 95% CI | p | |
Gestational age | 1.1 | 0.37–1.8 | 0.007 * | −0.9 | −3.4–1.6 | 0.419 | −16.3 | −28.7–−3.8 | 0.015 * |
BW (percentile) | 0.031 | −2.82–0.114 | 0.407 | 0.40 | −0.11–0.19 | 0.555 | 0.7 | −0.3–1.9 | 0.152 |
IVH (grade) | −1.6 | −5.7–2.4 | 0.380 | −3.7 | −11.4–3.9 | 0.289 | −55.8 | −114.5–2.8 | 0.059 |
cb-IPs | 0.002 | −0.013–0.016 | 0.815 | 0.012 | −0.015–0.040 | 0.336 | −0.101 | −0.10–3.111 | 0.292 |
Univariate Regression Analyses | |||||||||
---|---|---|---|---|---|---|---|---|---|
ISI | SAT RATE | Pct Time Under 5 | |||||||
R = 0.48 | R = 0.56 | R = 0.13 | |||||||
B | 95% CI | p | B | 95% CI | p | B | 95% CI | p | |
pl-IPs | 0.038 | 0.006–0.071 | 0.023 * | −0.039 | −0.065–0.012 | 0.006 * | 0.068 | −0.170– 0.307 | 0.558 |
Multivariate Regression Analyses | |||||||||
ISI | SAT RATE | Pct Time Under 5 | |||||||
R = 0.68 | R = 0.58 | R = 0.60 | |||||||
B | 95% CI | p | B | 95% CI | p | B | 95% CI | p | |
Gestational age | 0.007 | −0.377–0.391 | 0.971 | 0.1 | −0.3–0.5 | 0.557 | −7.5 | −13.8–−1.2 | 0.022 * |
FiO2 | 0.2 | −0.2–0.7 | 0.105 | 0.2 | −0.2–0.7 | 0.323 | 0.08 | −2.0–1.9 | 0.931 |
IVH (grade) | 1.6 | 0.1–3.2 | 0.038 * | −0.8 | −2.8–1.0 | 0.332 | 4.3 | −6.4–15.1 | 0.410 |
pl-IPs | 0.030 | 0.003–0.058 | 0.034 * | −0.041 | −0.069–0.013 | 0.007 * | 0.139 | −0.101–0.378 | 0.240 |
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Coviello, C.; Perrone, S.; Buonocore, G.; Negro, S.; Longini, M.; Groenendaal, F.; Vijlbrief, D.C.; Dani, C.; Benders, M.J.N.L.; Tataranno, M.L. Oxidative Stress Biomarkers and Early Brain Activity in Extremely Preterm Infants: A Prospective Cohort Study. Children 2022, 9, 1376. https://doi.org/10.3390/children9091376
Coviello C, Perrone S, Buonocore G, Negro S, Longini M, Groenendaal F, Vijlbrief DC, Dani C, Benders MJNL, Tataranno ML. Oxidative Stress Biomarkers and Early Brain Activity in Extremely Preterm Infants: A Prospective Cohort Study. Children. 2022; 9(9):1376. https://doi.org/10.3390/children9091376
Chicago/Turabian StyleCoviello, Caterina, Serafina Perrone, Giuseppe Buonocore, Simona Negro, Mariangela Longini, Floris Groenendaal, Daniel C. Vijlbrief, Carlo Dani, Manon J. N. L. Benders, and Maria Luisa Tataranno. 2022. "Oxidative Stress Biomarkers and Early Brain Activity in Extremely Preterm Infants: A Prospective Cohort Study" Children 9, no. 9: 1376. https://doi.org/10.3390/children9091376