Do Mast Cells Contribute to the Antifungal Host Defense?
Abstract
:1. Introduction
2. Microscopic Fungi and the Immune System
3. How Do MCs Contribute to the Host Defense?
4. Expression of PRRs Involved in Fungus Recognition in MCs
5. Fungi Affect MC Activity
5.1. Effect of Fungal Cells on MCs
5.2. Effect of Fungus-Derived Molecules on MCs
6. MCs and Th17 Cells
7. Concluding Remarks
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Fungi | MC Types | Mediators | References |
---|---|---|---|
Aspergillus fumigatus (mature hyphae) | RBL-2H3 | histamine, β-hexosaminidase | [58] |
Candida albicans | HMC-1 | IL-1Ra, IL-16, MIF, CXCL8 | [57] |
Candida albicans (hyphae) | SMCs | TGF-β and IL-10 | [59] |
Candida albicans (yeasts) | BMMCs | IL-1β | [55] |
Candida albicans (hyphae, yeasts) | BMMCs | TNF, IL-6, IL-10, IL-13, CCL3, CCL4 | [55,60] |
Candida albicans (cell wall, hyphae, yeasts) | BMMCs, HMC-1, PMCs, RBL-2H3 | histamine, β-hexosaminidase | [55,56,57] |
Cryptococcus neoformans | CBMCs, HMC-1 | β-hexosaminidase, tryptase | [61] |
Malasezzia sympodialis | BMMCs, PMCs IgE-sensitized BMMCs PBMCs | cysLTs, TNF, IL-6 histamine, cysLTs, CCL2 IL-6 | [37,62] |
Paracoccidioides brasiliensis | RBL-2H3 | histamine, β-hexosaminidase | [63] |
Sporothrix schenckii | BMMCs, PMCs | cysLTs, TNF, IL-6 | [64,65,66] |
Fungus-Derived Molecules | MC Types | Mediators | References |
---|---|---|---|
curdlan (Alcaligensis faecalis) | PMCs | histamine, cysLTs, TNF, IFN-α, IFN-γ CCL3, GM-CSF, ROS | [38,87] |
BMMCs | histamine, β-hexosaminidase | ||
glycoprotein (Candida albicans) | PMCs | histamine | [80] |
lectin (Aspergillus oryzae) | IgE-sensitized RBL-2H3 | β-hexosaminidase | [81] |
mannan (Candida albicans) | RBL-2H3 | histamine, β-hexosaminidase | [56,82,83,84] |
mannan (Saccharomyces cerevisiae) | PMCs | histamine, cysLTs, TNF, CCL2, CCL3, IFN-γ, GM-CSF, ROS | |
PbPga1 (Paracoccidioides brasiliensis) | RBL-2H3 | IL-6 | [63] |
zymosan (Saccharomyces cerevisiae) | BMMCs CBMCs PMCs | ROS, NO LTB4, LTC4, IL-1β, GM-CSF histamine, cysLTs, TNF, IFNs, GM-CSF, CCL2, ROS | [35,82,83,84,88] |
β-glucan (Candida albicans) | RBL-2H3 | histamine, β-hexosaminidase | [56] |
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Żelechowska, P.; Pastwińska, J.; Brzezińska-Błaszczyk, E.; Agier, J. Do Mast Cells Contribute to the Antifungal Host Defense? Cells 2021, 10, 2510. https://doi.org/10.3390/cells10102510
Żelechowska P, Pastwińska J, Brzezińska-Błaszczyk E, Agier J. Do Mast Cells Contribute to the Antifungal Host Defense? Cells. 2021; 10(10):2510. https://doi.org/10.3390/cells10102510
Chicago/Turabian StyleŻelechowska, Paulina, Joanna Pastwińska, Ewa Brzezińska-Błaszczyk, and Justyna Agier. 2021. "Do Mast Cells Contribute to the Antifungal Host Defense?" Cells 10, no. 10: 2510. https://doi.org/10.3390/cells10102510