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EDITORIAL article

Front. Pharmacol., 01 February 2023
Sec. Ethnopharmacology
Volume 14 - 2023 | https://doi.org/10.3389/fphar.2023.1134989
This article is part of the Research Topic Regulation of PI3K/Akt Signaling Pathway: A Feasible Approach for Natural Neuroprotective Agents to Treat Various Neuron Injury-Related Diseases View all 8 articles

Editorial: Regulation of PI3K/Akt signaling pathway: A feasible approach for natural neuroprotective agents to treat various neuron injury-related diseases

Yunhui Chen Yunhui Chen1*Charles HsuCharles Hsu2Xiuping ChenXiuping Chen3Heng ZhangHeng Zhang4Wei Peng Wei Peng1*
  • 1School of Basic Medicine/School of International Education/School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China
  • 2College of Medicine, Qatar University, Doha, Qatar
  • 3Institute of Chinese Medical Sciences, University of Macau, Macau, China
  • 4West China Hospital, Sichuan University, Chengdu, China

Editorial on the Research Topic
Regulation of PI3K/Akt signaling pathway: A feasible approach for natural neuroprotective agents to treat various neuron injury-related diseases

Neuron injury is closely associated with the development of various diseases, such as Alzheimer’s disease, spinal cord injury, ischemic stroke, and depression. The phosphoinositide-3-kinase (PI3K)/protein kinase B(Akt) signaling pathway is vital for neuron cell growth, development, and survival and can suppress cell apoptosis via downregulating proapoptosis proteins. In recent years, a growing body of research has suggested that natural agents are beneficial for preventing or treating neuron injury-related diseases via modulating the classical PI3K/Akt signaling pathway. This Research Topic “Regulation of PI3K/Akt Signaling Pathway: A Feasible Approach for Natural Neuroprotective Agents to Treat Various Neuron Injury-Related Diseases” provided an academic platform to discuss the novel natural neuroprotective agents and how they can be used to treat various neurodegenerative diseases regulating PI3K/Akt Signaling Pathway.

Using network pharmacology and in vitro experiments, Li et al. investigated the neuroprotective effects of Alpiniae oxyphyllae Fructus (AOF) on H2O2 stimulated PC12 cells, and the results suggested that AOF had the potential to treat Alzheimer’s disease by suppressing apoptosis induced by oxidative stress via the PI3K/Akt pathway. Liu et al. constructed an in vitro neuronal axotomy model to study the therapeutic effects of zinc oxide nanoparticles (ZnO NPs) on spinal cord injury (SCI) and found that ZnO NPs could act as a neuroprotective agent to reduce oxidative stress levels and rescue the neuronal apoptosis via the PI3K-Akt signaling pathway, providing new insights for SCI diagnosis and therapeutics. Yang et al. reported that Monomethyl lithospermate (MOL), a constituent of Shenxiong Tongmai granule, exerted a protective effect against neural damage caused by ischemic stroke in MCAO rats and OGR/R-induced SHSY-5Y cells, and its mechanism of actions attributed to the suppression of cell apoptosis through activating PI3K/Akt signaling pathway. Sun et al. adopted integrative approaches of network pharmacology and in vivo and in vitro experiments to study the antidepressant effect of essential oil from the roots of Paeonia lactiflora Pall (EOP) on corticosterone-induced depression and found that EOP might exert anti-apoptotic effects on hippocampal neurons through PI3K/Akt/Nrf2 signaling pathway. Tang et al. reported the antidepressant effects of the fruits of Zanthoxylum bungeanum Maxim. Essential oil (HEO) on chronic mild unpredictable stimulation (CUMS) mice via modulating the HPA axis and activating PI3K/Akt signaling pathway to reduce neuronal apoptosis. In addition, Xu et al. presented a review to describe and summarize recent research for sixteen natural terpenoids as neuroprotective agents associated with the PI3K/Akt pathway, providing a stepping stone for further research. And another review by Wang et al. illustrated that puerarin, a natural isoflavone extracted from the dried root of Pueraria montana var. Lobata (Willd.) Sanjappa and Predeep, could protect nerve cells and delay the progression of various neurological diseases through the PI3K/Akt signal pathway.

This Research Topic covers the latest scientific research on the regulation of PI3K/Akt signal pathway for natural products to treat different neuron injury-related diseases, including fundamental theory and experiments in vitro and in vivo. These investigations suggest that targeting PI3K/Akt signal pathway might be feasible for natural neuroprotective agents to manage such diseases as Alzheimer’s disease, spinal cord injury, ischemia stroke, and depression. However, other important neuro-injury related diseases have not been reported, such as Parkinson’s disease and epilepsy, and more investigations are warranted.

Author contributions

All authors listed have made a substantial, direct and intellectual contribution to the work, and approved it for publication.

Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Keywords: PI3K/AKT, natural agents, neuron injury, neuroprotective effect, drug discovery

Citation: Chen Y, Hsu C, Chen X, Zhang H and Peng W (2023) Editorial: Regulation of PI3K/Akt signaling pathway: A feasible approach for natural neuroprotective agents to treat various neuron injury-related diseases. Front. Pharmacol. 14:1134989. doi: 10.3389/fphar.2023.1134989

Received: 31 December 2022; Accepted: 23 January 2023;
Published: 01 February 2023.

Edited by:

Javier Echeverria, University of Santiago, Chile

Reviewed by:

Luca Rastrelli, University of Salerno, Italy

Copyright © 2023 Chen, Hsu, Chen, Zhang and Peng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Yunhui Chen, chenyunhui@cdutcm.edu.cn; Wei Peng, pengwei@cdutcm.edu.cn

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.