This article is a correction to:
Identification of Hypoxia Induced Metabolism Associated Genes in Pulmonary Hypertension
Yang-Yang He1
Xin-Mei Xie1
Hong-Da Zhang2
Jue Ye2
Selin Gencer3
Emiel P. C. van der Vorst3,4,5,6,7
Yvonne Döring3,4,8
Christian Weber3,4,9,10
Xiao-Bin Pang1
Zhi-Cheng Jing11
Yi Yan3,4*†
Zhi-Yan Han2*†- 1School of Pharmacy, Henan University, Kaifeng, China
- 2State Key Laboratory of Cardiovascular Disease and FuWai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
- 3Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University Munich, Munich, Germany
- 4DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany
- 5Interdisciplinary Center for Clinical Research (IZKF), RWTH Aachen University, Aachen, Germany
- 6Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany
- 7Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, Netherlands
- 8Department of Angiology, Swiss Cardiovascular Center, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
- 9Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, Netherlands
- 10Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
- 11State Key Laboratory of Complex, Severe, and Rare Diseases, and Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
A Corrigendum on
Identification of Hypoxia Induced Metabolism Associated Genes in Pulmonary Hypertension
by He Y.-Y., Xie X.-M., Zhang H.-D., Ye J., Gencer S., van der Vorst E. P. C., Döring Y., Weber C., Pang X.-B., Jing Z.-C., Yan Y., and Han Z.-Y. (2021). Front. Pharmacol. 12:753727. doi: 10.3389/fphar.2021.753727
In the original article, there was a mistake in the citation as published. In the citation, commas were missing between “He Y-Y and Xie X-M, Xie X-M and Zhang H-D, Zhang H-D and Ye J, Pang X-B and Jing Z-C, Jing Z-C and Yan Y”. The corrected citation should be “He Y-Y, Xie X-M, Zhang H-D, Ye J, Gencer S, van der Vorst EPC, Döring Y, Weber C, Pang X-B, Jing Z-C, Yan Y and Han Z-Y (2021) Identification of Hypoxia Induced Metabolism Associated Genes in Pulmonary Hypertension. Front. Pharmacol. 12:753727. doi:10.3389/fphar.2021.753727.”
In addition, there was a mistake in Figure 6 as published. The x-axis labels for Figures 6B and 6C were incorrectly labelled as “specficity”. The corrected Figure 6 appears below.
FIGURE 6
FIGURE 6. Validation of hub genes in lungs of PH patients and a predicting model for PH. (A) Expression of six hypoxia induced metabolism associated hub genes in lung tissues of 58 patients with pulmonary hypertension (PH) and 25 control subjects from GSE117261. (B) ROC curve analysis of training set (GSE117261) using six hub genes. (C) ROC curve analysis of test set (GSE117261) using six hub genes. (D) PCA analysis demonstrated the distribution of data sets GSE117261 (red) and GSE24988 (green) before (upper panel) and after (lower panel) removal of batch effect. The distribution was visualized in scatter plot. (E) Expression of six hypoxia induced metabolism associated hub genes in lung tissues of 120 patients with pulmonary hypertension (PH) and 47 control subjects from GSE117261 and GSE24988 after correction of batch effect. Data represent mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 compared to corresponding control subjects, as analyzed by unpaired t test or Mann-Whitney U test respectively, as appropriate.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
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Keywords: pulmonary hypertension, hypoxia, metabolism associated genes, metabolomics, transcriptomics
Citation: He Y-Y, Xie X-M, Zhang H-D, Ye J, Gencer S, van der Vorst EPC, Döring Y, Weber C, Pang X-B, Jing Z-C, Yan Y and Han Z-Y (2021) Corrigendum: Identification of Hypoxia Induced Metabolism Associated Genes in Pulmonary Hypertension. Front. Pharmacol. 12:810178. doi: 10.3389/fphar.2021.810178
Received: 06 November 2021; Accepted: 26 November 2021;
Published: 15 December 2021.
Edited and reviewed by:
Xiaohui Li, Central South University, ChinaCopyright © 2021 He, Xie, Zhang, Ye, Gencer, van der Vorst, Döring, Weber, Pang, Jing, Yan and Han. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Yi Yan, yi.yan@med.uni-muenchen.de; Zhi-Yan Han, zhiyanhan2006@hotmail.com
†These authors have contributed equally to this work and share last authorship